These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Structural Analysis and Development of Notum Fragment Screening Hits. Zhao Y; Mahy W; Willis NJ; Woodward HL; Steadman D; Bayle ED; Atkinson BN; Sipthorp J; Vecchia L; Ruza RR; Harlos K; Jeganathan F; Constantinou S; Costa A; Kjær S; Bictash M; Salinas PC; Whiting P; Vincent JP; Fish PV; Jones EY ACS Chem Neurosci; 2022 Jul; 13(13):2060-2077. PubMed ID: 35731924 [TBL] [Abstract][Full Text] [Related]
5. Straightforward hit identification approach in fragment-based discovery of bromodomain-containing protein 4 (BRD4) inhibitors. Borysko P; Moroz YS; Vasylchenko OV; Hurmach VV; Starodubtseva A; Stefanishena N; Nesteruk K; Zozulya S; Kondratov IS; Grygorenko OO Bioorg Med Chem; 2018 Jul; 26(12):3399-3405. PubMed ID: 29764756 [TBL] [Abstract][Full Text] [Related]
6. Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. Johnson JA; Nicolaou CA; Kirberger SE; Pandey AK; Hu H; Pomerantz WCK ACS Med Chem Lett; 2019 Dec; 10(12):1648-1654. PubMed ID: 31857841 [TBL] [Abstract][Full Text] [Related]
7. Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Clegg MA; Bamborough P; Chung CW; Craggs PD; Gordon L; Grandi P; Leveridge M; Lindon M; Liwicki GM; Michon AM; Molnar J; Rioja I; Soden PE; Theodoulou NH; Werner T; Tomkinson NCO; Prinjha RK; Humphreys PG J Med Chem; 2020 Jun; 63(11):5816-5840. PubMed ID: 32410449 [TBL] [Abstract][Full Text] [Related]
8. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. Hay DA; Fedorov O; Martin S; Singleton DC; Tallant C; Wells C; Picaud S; Philpott M; Monteiro OP; Rogers CM; Conway SJ; Rooney TP; Tumber A; Yapp C; Filippakopoulos P; Bunnage ME; Müller S; Knapp S; Schofield CJ; Brennan PE J Am Chem Soc; 2014 Jul; 136(26):9308-19. PubMed ID: 24946055 [TBL] [Abstract][Full Text] [Related]
9. The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains. Unzue A; Zhao H; Lolli G; Dong J; Zhu J; Zechner M; Dolbois A; Caflisch A; Nevado C J Med Chem; 2016 Apr; 59(7):3087-97. PubMed ID: 26982797 [TBL] [Abstract][Full Text] [Related]
10. Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. Jalencas X; Berg H; Espeland LO; Sreeramulu S; Kinnen F; Richter C; Georgiou C; Yadrykhinsky V; Specker E; Jaudzems K; Miletić T; Harmel R; Gribbon P; Schwalbe H; Brenk R; Jirgensons A; Zaliani A; Mestres J RSC Med Chem; 2024 Apr; 15(4):1176-1188. PubMed ID: 38665834 [TBL] [Abstract][Full Text] [Related]
11. NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds. Yu JL; Chen TT; Zhou C; Lian FL; Tang XL; Wen Y; Shen JK; Xu YC; Xiong B; Zhang NX Acta Pharmacol Sin; 2016 Jul; 37(7):984-93. PubMed ID: 27238211 [TBL] [Abstract][Full Text] [Related]
12. Biochemical profiling of histone binding selectivity of the yeast bromodomain family. Zhang Q; Chakravarty S; Ghersi D; Zeng L; Plotnikov AN; Sanchez R; Zhou MM PLoS One; 2010 Jan; 5(1):e8903. PubMed ID: 20126658 [TBL] [Abstract][Full Text] [Related]
13. Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. Marchand JR; Dalle Vedove A; Lolli G; Caflisch A J Chem Inf Model; 2017 Oct; 57(10):2584-2597. PubMed ID: 28862840 [TBL] [Abstract][Full Text] [Related]
14. Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Drinkwater N; Vu H; Lovell KM; Criscione KR; Collins BM; Prisinzano TE; Poulsen SA; McLeish MJ; Grunewald GL; Martin JL Biochem J; 2010 Oct; 431(1):51-61. PubMed ID: 20642456 [TBL] [Abstract][Full Text] [Related]
15. Establish an automated flow injection ESI-MS method for the screening of fragment based libraries: Application to Hsp90. Riccardi Sirtori F; Caronni D; Colombo M; Dalvit C; Paolucci M; Regazzoni L; Visco C; Fogliatto G Eur J Pharm Sci; 2015 Aug; 76():83-94. PubMed ID: 25952103 [TBL] [Abstract][Full Text] [Related]
16. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Kidd SL; Fowler E; Reinhardt T; Compton T; Mateu N; Newman H; Bellini D; Talon R; McLoughlin J; Krojer T; Aimon A; Bradley A; Fairhead M; Brear P; Díaz-Sáez L; McAuley K; Sore HF; Madin A; O'Donovan DH; Huber KVM; Hyvönen M; von Delft F; Dowson CG; Spring DR Chem Sci; 2020 May; 11(39):10792-10801. PubMed ID: 34094333 [TBL] [Abstract][Full Text] [Related]
17. High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography. Lolli G; Caflisch A ACS Chem Biol; 2016 Mar; 11(3):800-7. PubMed ID: 26942307 [TBL] [Abstract][Full Text] [Related]
18. Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain. Spiliotopoulos D; Zhu J; Wamhoff EC; Deerain N; Marchand JR; Aretz J; Rademacher C; Caflisch A Bioorg Med Chem Lett; 2017 Jun; 27(11):2472-2478. PubMed ID: 28410781 [TBL] [Abstract][Full Text] [Related]
19. Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography. Recht MI; Sridhar V; Badger J; Bounaud PY; Logan C; Chie-Leon B; Nienaber V; Torres FE J Biomol Screen; 2014 Apr; 19(4):497-507. PubMed ID: 24375910 [TBL] [Abstract][Full Text] [Related]
20. Identification of a BAZ2A Bromodomain Hit Compound by Fragment Joining. Dalle Vedove A; Cazzanelli G; Corsi J; Sedykh M; D'Agostino VG; Caflisch A; Lolli G ACS Bio Med Chem Au; 2021 Dec; 1(1):5-10. PubMed ID: 36147311 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]