These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 29944345)

  • 1. Targeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate Synthase.
    Bartee D; Freel Meyers CL
    Biochemistry; 2018 Jul; 57(29):4349-4356. PubMed ID: 29944345
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism.
    Bartee D; Freel Meyers CL
    Acc Chem Res; 2018 Oct; 51(10):2546-2555. PubMed ID: 30203647
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria.
    DeColli AA; Nemeria NS; Majumdar A; Gerfen GJ; Jordan F; Freel Meyers CL
    J Biol Chem; 2018 Jul; 293(28):10857-10869. PubMed ID: 29784878
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.
    Sanders S; Vierling RJ; Bartee D; DeColli AA; Harrison MJ; Aklinski JL; Koppisch AT; Freel Meyers CL
    ACS Infect Dis; 2017 Jul; 3(7):467-478. PubMed ID: 28636325
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents.
    Bartee D; Sanders S; Phillips PD; Harrison MJ; Koppisch AT; Freel Meyers CL
    ACS Infect Dis; 2019 Mar; 5(3):406-417. PubMed ID: 30614674
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.
    Bartee D; Morris F; Al-Khouja A; Freel Meyers CL
    Chembiochem; 2015 Aug; 16(12):1771-81. PubMed ID: 26174207
    [TBL] [Abstract][Full Text] [Related]  

  • 7. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.
    Chen PY; DeColli AA; Freel Meyers CL; Drennan CL
    J Biol Chem; 2019 Aug; 294(33):12405-12414. PubMed ID: 31239351
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase.
    DeColli AA; Zhang X; Heflin KL; Jordan F; Freel Meyers CL
    Biochemistry; 2019 Dec; 58(49):4970-4982. PubMed ID: 31724401
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase.
    Toci EM; Austin SL; Majumdar A; Woodcock HL; Freel Meyers CL
    Biochemistry; 2024 Mar; 63(5):671-687. PubMed ID: 38393327
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate.
    Basta LAB; Patel H; Kakalis L; Jordan F; Meyers CLF
    FEBS J; 2014 Jun; 281(12):2820-2837. PubMed ID: 24767541
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.
    Zhou J; Yang L; DeColli A; Freel Meyers C; Nemeria NS; Jordan F
    Proc Natl Acad Sci U S A; 2017 Aug; 114(35):9355-9360. PubMed ID: 28808005
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate.
    Patel H; Nemeria NS; Brammer LA; Freel Meyers CL; Jordan F
    J Am Chem Soc; 2012 Nov; 134(44):18374-9. PubMed ID: 23072514
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent Inhibition of
    Coco LB; Toci EM; Chen PY; Drennan CL; Freel Meyers CL
    ACS Infect Dis; 2024 Apr; 10(4):1312-1326. PubMed ID: 38513073
    [TBL] [Abstract][Full Text] [Related]  

  • 14. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.
    Morris F; Vierling R; Boucher L; Bosch J; Freel Meyers CL
    Chembiochem; 2013 Jul; 14(11):1309-15. PubMed ID: 23824585
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.
    Smith JM; Warrington NV; Vierling RJ; Kuhn ML; Anderson WF; Koppisch AT; Freel Meyers CL
    J Antibiot (Tokyo); 2014 Jan; 67(1):77-83. PubMed ID: 24169798
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae.
    Matsue Y; Mizuno H; Tomita T; Asami T; Nishiyama M; Kuzuyama T
    J Antibiot (Tokyo); 2010 Oct; 63(10):583-8. PubMed ID: 20808315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.
    Sprenger GA; Schörken U; Wiegert T; Grolle S; de Graaf AA; Taylor SV; Begley TP; Bringer-Meyer S; Sahm H
    Proc Natl Acad Sci U S A; 1997 Nov; 94(24):12857-62. PubMed ID: 9371765
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Rhodobacter capsulatus 1-deoxy-D-xylulose 5-phosphate synthase: steady-state kinetics and substrate binding.
    Eubanks LM; Poulter CD
    Biochemistry; 2003 Feb; 42(4):1140-9. PubMed ID: 12549936
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.
    Singh VK; Ghosh I
    FEBS Lett; 2013 Sep; 587(17):2806-17. PubMed ID: 23816706
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.
    Altincicek B; Hintz M; Sanderbrand S; Wiesner J; Beck E; Jomaa H
    FEMS Microbiol Lett; 2000 Sep; 190(2):329-33. PubMed ID: 11034300
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.