These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

258 related articles for article (PubMed ID: 29966005)

  • 1. Dissecting conformational changes in APP's transmembrane domain linked to ε-efficiency in familial Alzheimer's disease.
    Götz A; Scharnagl C
    PLoS One; 2018; 13(7):e0200077. PubMed ID: 29966005
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.
    Götz A; Högel P; Silber M; Chaitoglou I; Luy B; Muhle-Goll C; Scharnagl C; Langosch D
    Sci Rep; 2019 Mar; 9(1):5321. PubMed ID: 30926830
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Familial L723P Mutation Can Shift the Distribution between the Alternative APP Transmembrane Domain Cleavage Cascades by Local Unfolding of the Ε-Cleavage Site Suggesting a Straightforward Mechanism of Alzheimer's Disease Pathogenesis.
    Bocharov EV; Nadezhdin KD; Urban AS; Volynsky PE; Pavlov KV; Efremov RG; Arseniev AS; Bocharova OV
    ACS Chem Biol; 2019 Jul; 14(7):1573-1582. PubMed ID: 31180641
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.
    Götz A; Mylonas N; Högel P; Silber M; Heinel H; Menig S; Vogel A; Feyrer H; Huster D; Luy B; Langosch D; Scharnagl C; Muhle-Goll C; Kamp F; Steiner H
    Biophys J; 2019 Jun; 116(11):2103-2120. PubMed ID: 31130234
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.
    Dimitrov M; Alattia JR; Lemmin T; Lehal R; Fligier A; Houacine J; Hussain I; Radtke F; Dal Peraro M; Beher D; Fraering PC
    Nat Commun; 2013; 4():2246. PubMed ID: 23907250
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.
    Gorman PM; Kim S; Guo M; Melnyk RA; McLaurin J; Fraser PE; Bowie JU; Chakrabartty A
    BMC Neurosci; 2008 Jan; 9():17. PubMed ID: 18234110
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein.
    Do HN; Devkota S; Bhattarai A; Wolfe MS; Miao Y
    Commun Biol; 2023 Feb; 6(1):174. PubMed ID: 36788318
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites.
    Yan Y; Xu TH; Harikumar KG; Miller LJ; Melcher K; Xu HE
    J Biol Chem; 2017 Sep; 292(38):15826-15837. PubMed ID: 28790170
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
    Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
    J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase.
    Dehury B; Somavarapu AK; Kepp KP
    J Struct Biol; 2020 Dec; 212(3):107648. PubMed ID: 33099014
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.
    Chen W; Gamache E; Rosenman DJ; Xie J; Lopez MM; Li YM; Wang C
    Nat Commun; 2014; 5():3037. PubMed ID: 24390130
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Designed Helical Peptides as Functional Probes for γ-Secretase.
    Philip AT; Devkota S; Malvankar S; Bhattarai S; Meneely KM; Williams TD; Wolfe MS
    Biochemistry; 2019 Nov; 58(44):4398-4407. PubMed ID: 31625391
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease.
    Wang H; Barreyro L; Provasi D; Djemil I; Torres-Arancivia C; Filizola M; Ubarretxena-Belandia I
    J Mol Biol; 2011 May; 408(5):879-95. PubMed ID: 21440556
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
    Schilling S; Pradhan A; Heesch A; Helbig A; Blennow K; Koch C; Bertgen L; Koo EH; Brinkmalm G; Zetterberg H; Kins S; Eggert S
    Acta Neuropathol Commun; 2023 Jun; 11(1):87. PubMed ID: 37259128
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP.
    Robinson A; Grösgen S; Mett J; Zimmer VC; Haupenthal VJ; Hundsdörfer B; Stahlmann CP; Slobodskoy Y; Müller UC; Hartmann T; Stein R; Grimm MO
    Aging Cell; 2014 Apr; 13(2):263-72. PubMed ID: 24304563
    [TBL] [Abstract][Full Text] [Related]  

  • 17. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
    McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL
    Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
    Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
    Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
    Weidemann A; Eggert S; Reinhard FB; Vogel M; Paliga K; Baier G; Masters CL; Beyreuther K; Evin G
    Biochemistry; 2002 Feb; 41(8):2825-35. PubMed ID: 11851430
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production.
    Suzuki R; Takahashi H; Yoshida C; Hidaka M; Ogawa T; Futai E
    Int J Mol Sci; 2023 Feb; 24(4):. PubMed ID: 36835396
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.