These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

257 related articles for article (PubMed ID: 29966005)

  • 41. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
    Kukar TL; Ladd TB; Robertson P; Pintchovski SA; Moore B; Bann MA; Ren Z; Jansen-West K; Malphrus K; Eggert S; Maruyama H; Cottrell BA; Das P; Basi GS; Koo EH; Golde TE
    J Biol Chem; 2011 Nov; 286(46):39804-12. PubMed ID: 21868378
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Epsilon-secretase: reduction of amyloid precursor protein epsilon-site cleavage in Alzheimer's disease.
    Kametani F
    Curr Alzheimer Res; 2008 Apr; 5(2):165-71. PubMed ID: 18393801
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Mechanism of Tripeptide Trimming of Amyloid β-Peptide 49 by γ-Secretase.
    Bhattarai A; Devkota S; Do HN; Wang J; Bhattarai S; Wolfe MS; Miao Y
    J Am Chem Soc; 2022 Apr; 144(14):6215-6226. PubMed ID: 35377629
    [TBL] [Abstract][Full Text] [Related]  

  • 44. How Mutations Perturb γ-Secretase Active Site Studied by Free Energy Simulations.
    Chen SY; Zacharias M
    ACS Chem Neurosci; 2020 Oct; 11(20):3321-3332. PubMed ID: 32960571
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Mutations in APP have independent effects on Abeta and CTFgamma generation.
    Hecimovic S; Wang J; Dolios G; Martinez M; Wang R; Goate AM
    Neurobiol Dis; 2004 Nov; 17(2):205-18. PubMed ID: 15474359
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.
    Imai S; Cai T; Yoshida C; Tomita T; Futai E
    J Biochem; 2019 Jan; 165(1):37-46. PubMed ID: 30289529
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
    Zhang C; Browne A; Kim DY; Tanzi RE
    Curr Alzheimer Res; 2010 Feb; 7(1):21-6. PubMed ID: 20205669
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Specific Mutations in Aph1 Cause γ-Secretase Activation.
    Watanabe H; Yoshida C; Hidaka M; Ogawa T; Tomita T; Futai E
    Int J Mol Sci; 2022 Jan; 23(1):. PubMed ID: 35008932
    [TBL] [Abstract][Full Text] [Related]  

  • 49. gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein.
    Bunnell WL; Pham HV; Glabe CG
    J Biol Chem; 1998 Nov; 273(48):31947-55. PubMed ID: 9822665
    [TBL] [Abstract][Full Text] [Related]  

  • 50. [Molecular basics of Alzheimer's disease].
    Grigorenko AP; Rogaev EI
    Mol Biol (Mosk); 2007; 41(2):331-45. PubMed ID: 17514900
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
    Page RM; Gutsmiedl A; Fukumori A; Winkler E; Haass C; Steiner H
    J Biol Chem; 2010 Jun; 285(23):17798-810. PubMed ID: 20348104
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.
    Lichtenthaler SF; Wang R; Grimm H; Uljon SN; Masters CL; Beyreuther K
    Proc Natl Acad Sci U S A; 1999 Mar; 96(6):3053-8. PubMed ID: 10077635
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.
    Serneels L; T'Syen D; Perez-Benito L; Theys T; Holt MG; De Strooper B
    Mol Neurodegener; 2020 Oct; 15(1):60. PubMed ID: 33076948
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.
    Okamoto T; Takeda S; Giambarella U; Murayama Y; Matsui T; Katada T; Matsuura Y; Nishimoto I
    EMBO J; 1996 Aug; 15(15):3769-77. PubMed ID: 8670881
    [TBL] [Abstract][Full Text] [Related]  

  • 56. The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.
    Pester O; Götz A; Multhaup G; Scharnagl C; Langosch D
    Chembiochem; 2013 Oct; 14(15):1943-8. PubMed ID: 24115334
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.
    Ousson S; Saric A; Baguet A; Losberger C; Genoud S; Vilbois F; Permanne B; Hussain I; Beher D
    J Neurochem; 2013 May; 125(4):610-9. PubMed ID: 23253155
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane.
    Audagnotto M; Kengo Lorkowski A; Dal Peraro M
    Biochem Biophys Res Commun; 2018 Mar; 498(2):334-341. PubMed ID: 29097209
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.
    Jang H; Arce FT; Ramachandran S; Kagan BL; Lal R; Nussinov R
    J Phys Chem B; 2013 Oct; 117(39):11518-29. PubMed ID: 24000923
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide.
    Tan J; Mao G; Cui MZ; Lamb B; Sy MS; Xu X
    Neurobiol Dis; 2009 Dec; 36(3):453-60. PubMed ID: 19716417
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.