416 related articles for article (PubMed ID: 29966870)
1. Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors.
Gabr MT; Abdel-Raziq MS
Bioorg Chem; 2018 Oct; 80():245-252. PubMed ID: 29966870
[TBL] [Abstract][Full Text] [Related]
2. Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.
Gabr MT; Abdel-Raziq MS
Bioorg Med Chem Lett; 2018 Sep; 28(17):2910-2913. PubMed ID: 30017317
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy.
Waiker DK; Verma A; Gajendra TA; Namrata ; Roy A; Kumar P; Trigun SK; Srikrishna S; Krishnamurthy S; Davisson VJ; Shrivastava SK
Eur J Med Chem; 2024 May; 271():116409. PubMed ID: 38663285
[TBL] [Abstract][Full Text] [Related]
4. Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.
Zhao XJ; Gong DM; Jiang YR; Guo D; Zhu Y; Deng YC
Eur J Med Chem; 2017 Sep; 138():738-747. PubMed ID: 28728106
[TBL] [Abstract][Full Text] [Related]
5. Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.
Sharma P; Tripathi A; Tripathi PN; Prajapati SK; Seth A; Tripathi MK; Srivastava P; Tiwari V; Krishnamurthy S; Shrivastava SK
Eur J Med Chem; 2019 Apr; 167():510-524. PubMed ID: 30784883
[TBL] [Abstract][Full Text] [Related]
6. Identification of aplysinopsin as a blood-brain barrier permeable scaffold for anti-cholinesterase and anti-BACE-1 activity.
Nuthakki VK; Yadav Bheemanaboina RR; Bharate SB
Bioorg Chem; 2021 Feb; 107():104568. PubMed ID: 33418314
[TBL] [Abstract][Full Text] [Related]
7. Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR).
Ferreira JPS; Albuquerque HMT; Cardoso SM; Silva AMS; Silva VLM
Eur J Med Chem; 2021 Oct; 221():113492. PubMed ID: 33984802
[TBL] [Abstract][Full Text] [Related]
8. Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H₃R and BACE 1 inhibitory activities.
Huang W; Tang L; Shi Y; Huang S; Xu L; Sheng R; Wu P; Li J; Zhou N; Hu Y
Bioorg Med Chem; 2011 Dec; 19(23):7158-67. PubMed ID: 22019465
[TBL] [Abstract][Full Text] [Related]
9. Novel Deoxyvasicinone-Donepezil Hybrids as Potential Multitarget Drug Candidates for Alzheimer's Disease.
Du H; Liu X; Xie J; Ma F
ACS Chem Neurosci; 2019 May; 10(5):2397-2407. PubMed ID: 30720268
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents.
El-Sayed NA; Farag AE; Ezzat MAF; Akincioglu H; Gülçin İ; Abou-Seri SM
Bioorg Chem; 2019 Dec; 93():103312. PubMed ID: 31586715
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Wang J; Wang ZM; Li XM; Li F; Wu JJ; Kong LY; Wang XB
Bioorg Med Chem; 2016 Sep; 24(18):4324-4338. PubMed ID: 27460699
[TBL] [Abstract][Full Text] [Related]
12. Dynamic Simulation, Docking and DFT Studies Applied to a Set of Anti-Acetylcholinesterase Inhibitors in the enzyme β-Secretase (BACE-1): An Important Therapeutic Target in Alzheimer`s disease.
Silva-Junior EF; Barcellos Franca PH; Quintans-Junior LJ; Mendonca-Junior FJB; Scotti L; Scotti MT; de Aquino TM; de Araujo-Junior JX
Curr Comput Aided Drug Des; 2017 Nov; 13(4):266-274. PubMed ID: 28382866
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure-activity relationship with a strong BBB permeability.
Jannat S; Balupuri A; Ali MY; Hong SS; Choi CW; Choi YH; Ku JM; Kim WJ; Leem JY; Kim JE; Shrestha AC; Ham HN; Lee KH; Kim DM; Kang NS; Park GH
Exp Mol Med; 2019 Feb; 51(2):1-18. PubMed ID: 30755593
[TBL] [Abstract][Full Text] [Related]
14. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Wang ZM; Cai P; Liu QH; Xu DQ; Yang XL; Wu JJ; Kong LY; Wang XB
Eur J Med Chem; 2016 Nov; 123():282-297. PubMed ID: 27484514
[TBL] [Abstract][Full Text] [Related]
15. Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease.
Tripathi A; Choubey PK; Sharma P; Seth A; Tripathi PN; Tripathi MK; Prajapati SK; Krishnamurthy S; Shrivastava SK
Eur J Med Chem; 2019 Dec; 183():111707. PubMed ID: 31561043
[TBL] [Abstract][Full Text] [Related]
16. Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors.
Green KD; Fosso MY; Garneau-Tsodikova S
Molecules; 2018 Dec; 23(12):. PubMed ID: 30544832
[TBL] [Abstract][Full Text] [Related]
17. New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Fernández-Bachiller MI; Pérez C; Monjas L; Rademann J; Rodríguez-Franco MI
J Med Chem; 2012 Feb; 55(3):1303-17. PubMed ID: 22243648
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Jiang N; Huang Q; Liu J; Liang N; Li Q; Li Q; Xie SS
Eur J Med Chem; 2018 Feb; 146():287-298. PubMed ID: 29407958
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and biological evaluation of ferulic acid based 1,3,4-oxadiazole hybrids as multifunctional therapeutics for the treatment of Alzheimer's disease.
Tripathi A; Choubey PK; Sharma P; Seth A; Saraf P; Shrivastava SK
Bioorg Chem; 2020 Jan; 95():103506. PubMed ID: 31887472
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.
Zhu Y; Xiao K; Ma L; Xiong B; Fu Y; Yu H; Wang W; Wang X; Hu D; Peng H; Li J; Gong Q; Chai Q; Tang X; Zhang H; Li J; Shen J
Bioorg Med Chem; 2009 Feb; 17(4):1600-13. PubMed ID: 19162488
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]