151 related articles for article (PubMed ID: 29970308)
1. Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Ghosh AK; Ghosh K; Brindisi M; Lendy EK; Yen YC; Kumaragurubaran N; Huang X; Tang J; Mesecar AD
Bioorg Med Chem Lett; 2018 Aug; 28(15):2605-2610. PubMed ID: 29970308
[TBL] [Abstract][Full Text] [Related]
2. Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.
Ghosh AK; Brindisi M; Yen YC; Xu X; Huang X; Devasamudram T; Bilcer G; Lei H; Koelsch G; Mesecar AD; Tang J
Bioorg Med Chem Lett; 2015 Feb; 25(3):668-72. PubMed ID: 25537272
[TBL] [Abstract][Full Text] [Related]
3. Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Winneroski LL; Schiffler MA; Erickson JA; May PC; Monk SA; Timm DE; Audia JE; Beck JP; Boggs LN; Borders AR; Boyer RD; Brier RA; Hudziak KJ; Klimkowski VJ; Garcia Losada P; Mathes BM; Stout SL; Watson BM; Mergott DJ
Bioorg Med Chem; 2015 Jul; 23(13):3260-8. PubMed ID: 26001341
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.
Ghosh AK; Brindisi M; Yen YC; Cárdenas EL; Ella-Menye JR; Kumaragurubaran N; Huang X; Tang J; Mesecar AD
Bioorg Med Chem Lett; 2017 Jun; 27(11):2432-2438. PubMed ID: 28427814
[TBL] [Abstract][Full Text] [Related]
5. Screening and Elucidation of Selected Natural Compounds for Anti- Alzheimer's Potential Targeting BACE-1 Enzyme: A Case Computational Study.
Ahmad SS; Akhtar S; Danish Rizvi SM; Kamal MA; Sayeed U; Khan MKA; Siddiqui MH; Arif JM
Curr Comput Aided Drug Des; 2017 Nov; 13(4):311-318. PubMed ID: 28413992
[TBL] [Abstract][Full Text] [Related]
6. Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Winneroski LL; Erickson JA; Green SJ; Lopez JE; Stout SL; Porter WJ; Timm DE; Audia JE; Barberis M; Beck JP; Boggs LN; Borders AR; Boyer RD; Brier RA; Hembre EJ; Hendle J; Garcia-Losada P; Minguez JM; Mathes BM; May PC; Monk SA; Rankovic Z; Shi Y; Watson BM; Yang Z; Mergott DJ
Bioorg Med Chem; 2020 Jan; 28(1):115194. PubMed ID: 31786008
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.
Ghosh AK; Kumaragurubaran N; Hong L; Lei H; Hussain KA; Liu CF; Devasamudram T; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J
J Am Chem Soc; 2006 Apr; 128(16):5310-1. PubMed ID: 16620080
[TBL] [Abstract][Full Text] [Related]
8. Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation.
Low JD; Bartberger MD; Cheng Y; Whittington D; Xue Q; Wood S; Allen JR; Minatti AE
Bioorg Med Chem Lett; 2018 Apr; 28(6):1111-1115. PubMed ID: 29426770
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors.
Liu J; Chen W; Xu Y; Ren S; Zhang W; Li Y
Bioorg Med Chem; 2015 May; 23(9):1963-74. PubMed ID: 25842365
[TBL] [Abstract][Full Text] [Related]
10. Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis.
Azimi S; Zonouzi A; Firuzi O; Iraji A; Saeedi M; Mahdavi M; Edraki N
Eur J Med Chem; 2017 Sep; 138():729-737. PubMed ID: 28728105
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
Ghosh AK; Kumaragurubaran N; Hong L; Kulkarni SS; Xu X; Chang W; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J
J Med Chem; 2007 May; 50(10):2399-407. PubMed ID: 17432843
[TBL] [Abstract][Full Text] [Related]
12. N-(2-(Piperazin-1-yl)phenyl)arylamide Derivatives as β-Secretase (BACE1) Inhibitors: Simple Synthesis by Ugi Four-Component Reaction and Biological Evaluation.
Edraki N; Firuzi O; Fatahi Y; Mahdavi M; Asadi M; Emami S; Divsalar K; Miri R; Iraji A; Khoshneviszadeh M; Firoozpour L; Shafiee A; Foroumadi A
Arch Pharm (Weinheim); 2015 May; 348(5):330-7. PubMed ID: 25787800
[TBL] [Abstract][Full Text] [Related]
13. Fragment-based discovery of BACE1 inhibitors using functional assays.
Godemann R; Madden J; Krämer J; Smith M; Fritz U; Hesterkamp T; Barker J; Höppner S; Hallett D; Cesura A; Ebneth A; Kemp J
Biochemistry; 2009 Nov; 48(45):10743-51. PubMed ID: 19799414
[TBL] [Abstract][Full Text] [Related]
14. Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1-myricetin a case study.
Chakraborty S; Kumar S; Basu S
Neurochem Int; 2011 Jul; 58(8):914-23. PubMed ID: 21354237
[TBL] [Abstract][Full Text] [Related]
15. Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction.
Nakahara K; Mitsuoka Y; Kasuya S; Yamamoto T; Yamamoto S; Ito H; Kido Y; Kusakabe KI
Eur J Med Chem; 2021 Apr; 216():113270. PubMed ID: 33765486
[TBL] [Abstract][Full Text] [Related]
16. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Ghosh AK; Devasamudram T; Hong L; DeZutter C; Xu X; Weerasena V; Koelsch G; Bilcer G; Tang J
Bioorg Med Chem Lett; 2005 Jan; 15(1):15-20. PubMed ID: 15582402
[TBL] [Abstract][Full Text] [Related]
17. Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Xu YZ; Yuan S; Bowers S; Hom RK; Chan W; Sham HL; Zhu YL; Beroza P; Pan H; Brecht E; Yao N; Lougheed J; Yan J; Tam D; Ren Z; Ruslim L; Bova MP; Artis DR
Bioorg Med Chem Lett; 2013 May; 23(10):3075-80. PubMed ID: 23570791
[TBL] [Abstract][Full Text] [Related]
18. Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bowers S; Xu YZ; Yuan S; Probst GD; Hom RK; Chan W; Konradi AW; Sham HL; Zhu YL; Beroza P; Pan H; Brecht E; Yao N; Lougheed J; Tam D; Ren Z; Ruslim L; Bova MP; Artis DR
Bioorg Med Chem Lett; 2013 Apr; 23(7):2181-6. PubMed ID: 23465612
[TBL] [Abstract][Full Text] [Related]
19. BACE1 inhibitors: a head group scan on a series of amides.
Woltering TJ; Wostl W; Hilpert H; Rogers-Evans M; Pinard E; Mayweg A; Göbel M; Banner DW; Benz J; Travagli M; Pollastrini M; Marconi G; Gabellieri E; Guba W; Mauser H; Andreini M; Jacobsen H; Power E; Narquizian R
Bioorg Med Chem Lett; 2013 Jul; 23(14):4239-43. PubMed ID: 23735744
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Probst GD; Bowers S; Sealy JM; Stupi B; Dressen D; Jagodzinska BM; Aquino J; Gailunas A; Truong AP; Tso L; Xu YZ; Hom RK; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Sham HL; Jagodzinski J; Toth G; Brecht E; Yao N; Pan H; Lin M; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Gauby S; Zmolek W; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2010 Oct; 20(20):6034-9. PubMed ID: 20822903
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
