These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Ghosh AK; Brindisi M; Yen YC; Cárdenas EL; Ella-Menye JR; Kumaragurubaran N; Huang X; Tang J; Mesecar AD Bioorg Med Chem Lett; 2017 Jun; 27(11):2432-2438. PubMed ID: 28427814 [TBL] [Abstract][Full Text] [Related]
5. Screening and Elucidation of Selected Natural Compounds for Anti- Alzheimer's Potential Targeting BACE-1 Enzyme: A Case Computational Study. Ahmad SS; Akhtar S; Danish Rizvi SM; Kamal MA; Sayeed U; Khan MKA; Siddiqui MH; Arif JM Curr Comput Aided Drug Des; 2017 Nov; 13(4):311-318. PubMed ID: 28413992 [TBL] [Abstract][Full Text] [Related]
6. Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints. Winneroski LL; Erickson JA; Green SJ; Lopez JE; Stout SL; Porter WJ; Timm DE; Audia JE; Barberis M; Beck JP; Boggs LN; Borders AR; Boyer RD; Brier RA; Hembre EJ; Hendle J; Garcia-Losada P; Minguez JM; Mathes BM; May PC; Monk SA; Rankovic Z; Shi Y; Watson BM; Yang Z; Mergott DJ Bioorg Med Chem; 2020 Jan; 28(1):115194. PubMed ID: 31786008 [TBL] [Abstract][Full Text] [Related]
7. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. Ghosh AK; Kumaragurubaran N; Hong L; Lei H; Hussain KA; Liu CF; Devasamudram T; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J J Am Chem Soc; 2006 Apr; 128(16):5310-1. PubMed ID: 16620080 [TBL] [Abstract][Full Text] [Related]
8. Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation. Low JD; Bartberger MD; Cheng Y; Whittington D; Xue Q; Wood S; Allen JR; Minatti AE Bioorg Med Chem Lett; 2018 Apr; 28(6):1111-1115. PubMed ID: 29426770 [TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors. Liu J; Chen W; Xu Y; Ren S; Zhang W; Li Y Bioorg Med Chem; 2015 May; 23(9):1963-74. PubMed ID: 25842365 [TBL] [Abstract][Full Text] [Related]
10. Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis. Azimi S; Zonouzi A; Firuzi O; Iraji A; Saeedi M; Mahdavi M; Edraki N Eur J Med Chem; 2017 Sep; 138():729-737. PubMed ID: 28728105 [TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. Ghosh AK; Kumaragurubaran N; Hong L; Kulkarni SS; Xu X; Chang W; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J J Med Chem; 2007 May; 50(10):2399-407. PubMed ID: 17432843 [TBL] [Abstract][Full Text] [Related]
12. N-(2-(Piperazin-1-yl)phenyl)arylamide Derivatives as β-Secretase (BACE1) Inhibitors: Simple Synthesis by Ugi Four-Component Reaction and Biological Evaluation. Edraki N; Firuzi O; Fatahi Y; Mahdavi M; Asadi M; Emami S; Divsalar K; Miri R; Iraji A; Khoshneviszadeh M; Firoozpour L; Shafiee A; Foroumadi A Arch Pharm (Weinheim); 2015 May; 348(5):330-7. PubMed ID: 25787800 [TBL] [Abstract][Full Text] [Related]
13. Fragment-based discovery of BACE1 inhibitors using functional assays. Godemann R; Madden J; Krämer J; Smith M; Fritz U; Hesterkamp T; Barker J; Höppner S; Hallett D; Cesura A; Ebneth A; Kemp J Biochemistry; 2009 Nov; 48(45):10743-51. PubMed ID: 19799414 [TBL] [Abstract][Full Text] [Related]
14. Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1-myricetin a case study. Chakraborty S; Kumar S; Basu S Neurochem Int; 2011 Jul; 58(8):914-23. PubMed ID: 21354237 [TBL] [Abstract][Full Text] [Related]
15. Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction. Nakahara K; Mitsuoka Y; Kasuya S; Yamamoto T; Yamamoto S; Ito H; Kido Y; Kusakabe KI Eur J Med Chem; 2021 Apr; 216():113270. PubMed ID: 33765486 [TBL] [Abstract][Full Text] [Related]
16. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Ghosh AK; Devasamudram T; Hong L; DeZutter C; Xu X; Weerasena V; Koelsch G; Bilcer G; Tang J Bioorg Med Chem Lett; 2005 Jan; 15(1):15-20. PubMed ID: 15582402 [TBL] [Abstract][Full Text] [Related]
17. Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors. Xu YZ; Yuan S; Bowers S; Hom RK; Chan W; Sham HL; Zhu YL; Beroza P; Pan H; Brecht E; Yao N; Lougheed J; Yan J; Tam D; Ren Z; Ruslim L; Bova MP; Artis DR Bioorg Med Chem Lett; 2013 May; 23(10):3075-80. PubMed ID: 23570791 [TBL] [Abstract][Full Text] [Related]
18. Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. Bowers S; Xu YZ; Yuan S; Probst GD; Hom RK; Chan W; Konradi AW; Sham HL; Zhu YL; Beroza P; Pan H; Brecht E; Yao N; Lougheed J; Tam D; Ren Z; Ruslim L; Bova MP; Artis DR Bioorg Med Chem Lett; 2013 Apr; 23(7):2181-6. PubMed ID: 23465612 [TBL] [Abstract][Full Text] [Related]
19. BACE1 inhibitors: a head group scan on a series of amides. Woltering TJ; Wostl W; Hilpert H; Rogers-Evans M; Pinard E; Mayweg A; Göbel M; Banner DW; Benz J; Travagli M; Pollastrini M; Marconi G; Gabellieri E; Guba W; Mauser H; Andreini M; Jacobsen H; Power E; Narquizian R Bioorg Med Chem Lett; 2013 Jul; 23(14):4239-43. PubMed ID: 23735744 [TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region. Probst GD; Bowers S; Sealy JM; Stupi B; Dressen D; Jagodzinska BM; Aquino J; Gailunas A; Truong AP; Tso L; Xu YZ; Hom RK; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Sham HL; Jagodzinski J; Toth G; Brecht E; Yao N; Pan H; Lin M; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Gauby S; Zmolek W; Quinn KP; Sauer JM Bioorg Med Chem Lett; 2010 Oct; 20(20):6034-9. PubMed ID: 20822903 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]