These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

283 related articles for article (PubMed ID: 29970614)

  • 1. Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the αV138M variant of human pyruvate dehydrogenase.
    Whitley MJ; Arjunan P; Nemeria NS; Korotchkina LG; Park YH; Patel MS; Jordan F; Furey W
    J Biol Chem; 2018 Aug; 293(34):13204-13213. PubMed ID: 29970614
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex.
    Seifert F; Ciszak E; Korotchkina L; Golbik R; Spinka M; Dominiak P; Sidhu S; Brauer J; Patel MS; Tittmann K
    Biochemistry; 2007 May; 46(21):6277-87. PubMed ID: 17474719
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of point mutations in patients with pyruvate dehydrogenase deficiency: role of methionine-181, proline-188, and arginine-349 in the alpha subunit.
    Tripatara A; Korotchkina LG; Patel MS
    Arch Biochem Biophys; 1999 Jul; 367(1):39-50. PubMed ID: 10375397
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient.
    Jacobia SJ; Korotchkina LG; Patel MS
    Biochim Biophys Acta; 2002 Jan; 1586(1):32-42. PubMed ID: 11781147
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct.
    Arjunan P; Sax M; Brunskill A; Chandrasekhar K; Nemeria N; Zhang S; Jordan F; Furey W
    J Biol Chem; 2006 Jun; 281(22):15296-303. PubMed ID: 16531404
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Insight to the interaction of the dihydrolipoamide acetyltransferase (E2) core with the peripheral components in the Escherichia coli pyruvate dehydrogenase complex via multifaceted structural approaches.
    Chandrasekhar K; Wang J; Arjunan P; Sax M; Park YH; Nemeria NS; Kumaran S; Song J; Jordan F; Furey W
    J Biol Chem; 2013 May; 288(21):15402-17. PubMed ID: 23580650
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex.
    Wang J; Nemeria NS; Chandrasekhar K; Kumaran S; Arjunan P; Reynolds S; Calero G; Brukh R; Kakalis L; Furey W; Jordan F
    J Biol Chem; 2014 May; 289(22):15215-30. PubMed ID: 24742683
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural and functional impact of clinically relevant E1α variants causing pyruvate dehydrogenase complex deficiency.
    Pavlu-Pereira H; Lousa D; Tomé CS; Florindo C; Silva MJ; de Almeida IT; Leandro P; Rivera I; Vicente JB
    Biochimie; 2021 Apr; 183():78-88. PubMed ID: 33588022
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effect of substitutions in the thiamin diphosphate-magnesium fold on the activation of the pyruvate dehydrogenase complex from Escherichia coli by cofactors and substrate.
    Yi J; Nemeria N; McNally A; Jordan F; Machado RS; Guest JR
    J Biol Chem; 1996 Dec; 271(52):33192-200. PubMed ID: 8969175
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular analysis of abnormal pyruvate dehydrogenase in a patient with thiamine-responsive congenital lactic acidemia.
    Naito E; Ito M; Takeda E; Yokota I; Yoshijima S; Kuroda Y
    Pediatr Res; 1994 Sep; 36(3):340-6. PubMed ID: 7808831
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
    Liu S; Gong X; Yan X; Peng T; Baker JC; Li L; Robben PM; Ravindran S; Andersson LA; Cole AB; Roche TE
    Arch Biochem Biophys; 2001 Feb; 386(2):123-35. PubMed ID: 11368334
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
    Kato M; Wynn RM; Chuang JL; Tso SC; Machius M; Li J; Chuang DT
    Structure; 2008 Dec; 16(12):1849-59. PubMed ID: 19081061
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit.
    Park YH; Wei W; Zhou L; Nemeria N; Jordan F
    Biochemistry; 2004 Nov; 43(44):14037-46. PubMed ID: 15518552
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Thiamine-responsive pyruvate dehydrogenase deficiency in two patients caused by a point mutation (F205L and L216F) within the thiamine pyrophosphate binding region.
    Naito E; Ito M; Yokota I; Saijo T; Matsuda J; Ogawa Y; Kitamura S; Takada E; Horii Y; Kuroda Y
    Biochim Biophys Acta; 2002 Oct; 1588(1):79-84. PubMed ID: 12379317
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1',4'-imino tautomeric form of the coenzyme, unlike the michaelis complex or the free coenzyme.
    Nemeria N; Baykal A; Joseph E; Zhang S; Yan Y; Furey W; Jordan F
    Biochemistry; 2004 Jun; 43(21):6565-75. PubMed ID: 15157089
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 2-Oxo-3-alkynoic acids, universal mechanism-based inactivators of thiamin diphosphate-dependent decarboxylases: synthesis and evidence for potent inactivation of the pyruvate dehydrogenase multienzyme complex.
    Brown A; Nemeria N; Yi J; Zhang D; Jordan WB; Machado RS; Guest JR; Jordan F
    Biochemistry; 1997 Jul; 36(26):8071-81. PubMed ID: 9201955
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Studies on the regulation of the mitochondrial alpha-ketoacid dehydrogenase complexes and their kinases.
    Harris RA; Hawes JW; Popov KM; Zhao Y; Shimomura Y; Sato J; Jaskiewicz J; Hurley TD
    Adv Enzyme Regul; 1997; 37():271-93. PubMed ID: 9381974
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel binding motif and new flexibility revealed by structural analyses of a pyruvate dehydrogenase-dihydrolipoyl acetyltransferase subcomplex from the Escherichia coli pyruvate dehydrogenase multienzyme complex.
    Arjunan P; Wang J; Nemeria NS; Reynolds S; Brown I; Chandrasekhar K; Calero G; Jordan F; Furey W
    J Biol Chem; 2014 Oct; 289(43):30161-76. PubMed ID: 25210042
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Systematic study of the six cysteines of the E1 subunit of the pyruvate dehydrogenase multienzyme complex from Escherichia coli: none is essential for activity.
    Nemeria N; Volkov A; Brown A; Yi J; Zipper L; Guest JR; Jordan F
    Biochemistry; 1998 Jan; 37(3):911-22. PubMed ID: 9454581
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Determination of pre-steady-state rate constants on the Escherichia coli pyruvate dehydrogenase complex reveals that loop movement controls the rate-limiting step.
    Balakrishnan A; Nemeria NS; Chakraborty S; Kakalis L; Jordan F
    J Am Chem Soc; 2012 Nov; 134(45):18644-55. PubMed ID: 23088422
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.