BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 29976459)

  • 21. Alzheimer's disease. A firm base for drug development.
    De Strooper B; König G
    Nature; 1999 Dec; 402(6761):471-2. PubMed ID: 10591201
    [No Abstract]   [Full Text] [Related]  

  • 22. Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - development of potential agents for the treatment of Alzheimer's disease.
    Linning P; Haussmann U; Beyer I; Weidlich S; Schieb H; Wiltfang J; Klafki HW; Knölker HJ
    Org Biomol Chem; 2012 Oct; 10(41):8216-35. PubMed ID: 22930158
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story.
    Stamford A; Strickland C
    Curr Opin Chem Biol; 2013 Jun; 17(3):320-8. PubMed ID: 23683349
    [TBL] [Abstract][Full Text] [Related]  

  • 24. BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
    Clarke B; Demont E; Dingwall C; Dunsdon R; Faller A; Hawkins J; Hussain I; MacPherson D; Maile G; Matico R; Milner P; Mosley J; Naylor A; O'Brien A; Redshaw S; Riddell D; Rowland P; Soleil V; Smith KJ; Stanway S; Stemp G; Sweitzer S; Theobald P; Vesey D; Walter DS; Ward J; Wayne G
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1017-21. PubMed ID: 18166458
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Introduction to special issue on Alzheimer's disease.
    Wolfe MS
    J Med Chem; 2012 Nov; 55(21):8977-8. PubMed ID: 23039833
    [No Abstract]   [Full Text] [Related]  

  • 26. [BACE1 inhibitors for the treatment of Alzheimer disease].
    Tomita T
    Nihon Rinsho; 2016 Mar; 74(3):427-31. PubMed ID: 27025081
    [TBL] [Abstract][Full Text] [Related]  

  • 27. BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.
    Barão S; Moechars D; Lichtenthaler SF; De Strooper B
    Trends Neurosci; 2016 Mar; 39(3):158-169. PubMed ID: 26833257
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.
    Shimmyo Y; Kihara T; Akaike A; Niidome T; Sugimoto H
    Biochim Biophys Acta; 2008 May; 1780(5):819-25. PubMed ID: 18295609
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
    Probst GD; Bowers S; Sealy JM; Stupi B; Dressen D; Jagodzinska BM; Aquino J; Gailunas A; Truong AP; Tso L; Xu YZ; Hom RK; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Sham HL; Jagodzinski J; Toth G; Brecht E; Yao N; Pan H; Lin M; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Gauby S; Zmolek W; Quinn KP; Sauer JM
    Bioorg Med Chem Lett; 2010 Oct; 20(20):6034-9. PubMed ID: 20822903
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review.
    Rampa A; Gobbi S; Concetta Di Martino RM; Belluti F; Bisi A
    Curr Top Med Chem; 2017; 17(31):3361-3369. PubMed ID: 29332582
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
    Brodney MA; Barreiro G; Ogilvie K; Hajos-Korcsok E; Murray J; Vajdos F; Ambroise C; Christoffersen C; Fisher K; Lanyon L; Liu J; Nolan CE; Withka JM; Borzilleri KA; Efremov I; Oborski CE; Varghese A; O'Neill BT
    J Med Chem; 2012 Nov; 55(21):9224-39. PubMed ID: 22984865
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Computational methods in the discovery and design of BACE-1 inhibitors.
    Kacker P; Bottegoni G; Cavalli A
    Curr Med Chem; 2012; 19(36):6095-111. PubMed ID: 23072352
    [TBL] [Abstract][Full Text] [Related]  

  • 33. In Silico Inhibition of BACE-1 by Selective Phytochemicals as Novel Potential Inhibitors: Molecular Docking and DFT Studies.
    Arif N; Subhani A; Hussain W; Rasool N
    Curr Drug Discov Technol; 2020; 17(3):397-411. PubMed ID: 30767744
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.
    Saric A; Brügge Lz; Müller-Pompalla D; Rysiok T; Ousson S; Permanne B; Quattropani A; Busch M; Beher D; Hussain I
    J Biomol Screen; 2013 Mar; 18(3):277-85. PubMed ID: 23023105
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Novel non-peptide beta-secretase inhibitors derived from structure-based virtual screening and bioassay.
    Xu W; Chen G; Liew OW; Zuo Z; Jiang H; Zhu W
    Bioorg Med Chem Lett; 2009 Jun; 19(12):3188-92. PubMed ID: 19447035
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease.
    Huang W; Lv D; Yu H; Sheng R; Kim SC; Wu P; Luo K; Li J; Hu Y
    Bioorg Med Chem; 2010 Aug; 18(15):5610-5. PubMed ID: 20620068
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.
    Chen JJ; Liu Q; Yuan C; Gore V; Lopez P; Ma V; Amegadzie A; Qian W; Judd TC; Minatti AE; Brown J; Cheng Y; Xue M; Zhong W; Dineen TA; Epstein O; Human J; Kreiman C; Marx I; Weiss MM; Hitchcock SA; Powers TS; Chen K; Wen PH; Whittington DA; Cheng AC; Bartberger MD; Hickman D; Werner JA; Vargas HM; Everds NE; Vonderfecht SL; Dunn RT; Wood S; Fremeau RT; White RD; Patel VF
    Bioorg Med Chem Lett; 2015 Feb; 25(4):767-74. PubMed ID: 25613679
    [TBL] [Abstract][Full Text] [Related]  

  • 38. [Beta-secretase inhibitor].
    Fukumoto H
    Nihon Rinsho; 2011 Dec; 69 Suppl 10 Pt 2():88-92. PubMed ID: 22755161
    [No Abstract]   [Full Text] [Related]  

  • 39. Hydrogen sulfide reduces mRNA and protein levels of β-site amyloid precursor protein cleaving enzyme 1 in PC12 cells.
    Zhang H; Gao Y; Zhao F; Dai Z; Meng T; Tu S; Yan Y
    Neurochem Int; 2011 Feb; 58(2):169-75. PubMed ID: 21095213
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
    Neumann U; Rueeger H; Machauer R; Veenstra SJ; Lueoend RM; Tintelnot-Blomley M; Laue G; Beltz K; Vogg B; Schmid P; Frieauff W; Shimshek DR; Staufenbiel M; Jacobson LH
    Mol Neurodegener; 2015 Sep; 10():44. PubMed ID: 26336937
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.