BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 29976570)

  • 1. Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism.
    Maurer D; Lohkamp B; Krumpel M; Widersten M; Dobritzsch D
    Biochem J; 2018 Jul; 475(14):2395-2416. PubMed ID: 29976570
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces.
    Cederfelt D; Badgujar D; Au Musse A; Lohkamp B; Danielson UH; Dobritzsch D
    Biomolecules; 2023 Dec; 13(12):. PubMed ID: 38136634
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly.
    Lundgren S; Lohkamp B; Andersen B; Piskur J; Dobritzsch D
    J Mol Biol; 2008 Apr; 377(5):1544-59. PubMed ID: 18336837
    [TBL] [Abstract][Full Text] [Related]  

  • 4. ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients.
    van Kuilenburg AB; Dobritzsch D; Meijer J; Krumpel M; Selim LA; Rashed MS; Assmann B; Meinsma R; Lohkamp B; Ito T; Abeling NG; Saito K; Eto K; Smitka M; Engvall M; Zhang C; Xu W; Zoetekouw L; Hennekam RC
    Biochim Biophys Acta; 2012 Jul; 1822(7):1096-108. PubMed ID: 22525402
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements.
    Lundgren S; Andersen B; Piskur J; Dobritzsch D
    J Biol Chem; 2007 Dec; 282(49):36037-47. PubMed ID: 17916556
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The 3-ureidopropionase of Caenorhabditis elegans, an enzyme involved in pyrimidine degradation.
    Janowitz T; Ajonina I; Perbandt M; Woltersdorf C; Hertel P; Liebau E; Gigengack U
    FEBS J; 2010 Oct; 277(19):4100-9. PubMed ID: 20840592
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster.
    Lundgren S; Andersen B; Piskur J; Dobritzsch D
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2007 Oct; 63(Pt 10):874-7. PubMed ID: 17909293
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity.
    Lohkamp B; Andersen B; Piškur J; Dobritzsch D
    J Biol Chem; 2006 May; 281(19):13762-13776. PubMed ID: 16517602
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme.
    Hsieh JY; Liu JH; Fang YW; Hung HC
    Biochem J; 2009 May; 420(2):201-9. PubMed ID: 19236308
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyrimidine-degrading enzymes. Purification and properties of beta-ureidopropionase of Euglena gracilis.
    Wasternack C; Lippmann G; Reinbotte H
    Biochim Biophys Acta; 1979 Oct; 570(2):341-51. PubMed ID: 115499
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Clinical, biochemical and molecular analysis of 13 Japanese patients with β-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation [corrected].
    Nakajima Y; Meijer J; Dobritzsch D; Ito T; Meinsma R; Abeling NG; Roelofsen J; Zoetekouw L; Watanabe Y; Tashiro K; Lee T; Takeshima Y; Mitsubuchi H; Yoneyama A; Ohta K; Eto K; Saito K; Kuhara T; van Kuilenburg AB
    J Inherit Metab Dis; 2014 Sep; 37(5):801-12. PubMed ID: 24526388
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural and biochemical characterisation of the N-carbamoyl-β-alanine amidohydrolase from Rhizobium radiobacter MDC 8606.
    Paloyan A; Sargsyan A; Karapetyan MD; Hambardzumyan A; Kocharov S; Panosyan H; Dyukova K; Kinosyan M; Krueger A; Piergentili C; Stanley WA; Djoko KY; Baslé A; Marles-Wright J; Antranikian G
    FEBS J; 2023 Dec; 290(23):5566-5580. PubMed ID: 37634202
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure and site-directed mutagenesis studies of N-carbamoyl-D-amino-acid amidohydrolase from Agrobacterium radiobacter reveals a homotetramer and insight into a catalytic cleft.
    Wang WC; Hsu WH; Chien FT; Chen CY
    J Mol Biol; 2001 Feb; 306(2):251-61. PubMed ID: 11237598
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Amidohydrolases of the reductive pyrimidine catabolic pathway purification, characterization, structure, reaction mechanisms and enzyme deficiency.
    Schnackerz KD; Dobritzsch D
    Biochim Biophys Acta; 2008 Mar; 1784(3):431-44. PubMed ID: 18261476
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutagenic studies on histidine 98 of methylglyoxal synthase: effects on mechanism and conformational change.
    Marks GT; Susler M; Harrison DH
    Biochemistry; 2004 Apr; 43(13):3802-13. PubMed ID: 15049687
    [TBL] [Abstract][Full Text] [Related]  

  • 16. β-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity.
    Dobritzsch D; Meijer J; Meinsma R; Maurer D; Monavari AA; Gummesson A; Reims A; Cayuela JA; Kuklina N; Benoist JF; Perrin L; Assmann B; Hoffmann GF; Bierau J; Kaindl AM; van Kuilenburg ABP
    Mol Genet Metab; 2022 Jul; 136(3):177-185. PubMed ID: 35151535
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical and mutational studies of allantoinase from Bacillus licheniformis CECT 20T.
    Martínez-Gómez AI; Soriano-Maldonado P; Andújar-Sánchez M; Clemente-Jiménez JM; Rodríguez-Vico F; Neira JL; Las Heras-Vázquez FJ; Martínez-Rodríguez S
    Biochimie; 2014 Apr; 99():178-88. PubMed ID: 24333989
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystal structure of dihydropyrimidinase in complex with anticancer drug 5-fluorouracil.
    Huang YH; Ning ZJ; Huang CY
    Biochem Biophys Res Commun; 2019 Oct; 519(1):160-165. PubMed ID: 31481233
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of metal-dependent allantoinase from Escherichia coli.
    Kim K; Kim MI; Chung J; Ahn JH; Rhee S
    J Mol Biol; 2009 Apr; 387(5):1067-74. PubMed ID: 19248789
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of Protein Dimeric Interface in Allosteric Inhibition of N-Acetyl-Aspartate Hydrolysis by Human Aspartoacylase.
    Kots ED; Lushchekina SV; Varfolomeev SD; Nemukhin AV
    J Chem Inf Model; 2017 Aug; 57(8):1999-2008. PubMed ID: 28737906
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.