165 related articles for article (PubMed ID: 29980790)
1. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.
Johnson CE; Dunlop EA; Seifan S; McCann HD; Hay T; Parfitt GJ; Jones AT; Giles PJ; Shen MH; Sampson JR; Errington RJ; Davies DM; Tee AR
Oncogene; 2018 Nov; 37(45):5913-5925. PubMed ID: 29980790
[TBL] [Abstract][Full Text] [Related]
2. Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.
Dunlop EA; Johnson CE; Wiltshire M; Errington RJ; Tee AR
Oncotarget; 2017 Jul; 8(30):48711-48724. PubMed ID: 28415776
[TBL] [Abstract][Full Text] [Related]
3. Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.
Johnson CE; Hunt DK; Wiltshire M; Herbert TP; Sampson JR; Errington RJ; Davies DM; Tee AR
Mol Oncol; 2015 Mar; 9(3):675-88. PubMed ID: 25498902
[TBL] [Abstract][Full Text] [Related]
4. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA
J Biol Chem; 2013 May; 288(22):15687-98. PubMed ID: 23612979
[TBL] [Abstract][Full Text] [Related]
5. Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment.
McCann HD; Johnson CE; Errington RJ; Davies DM; Dunlop EA; Tee AR
Cancers (Basel); 2018 Oct; 10(10):. PubMed ID: 30308940
[TBL] [Abstract][Full Text] [Related]
6. Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.
Siroky BJ; Yin H; Babcock JT; Lu L; Hellmann AR; Dixon BP; Quilliam LA; Bissler JJ
Am J Physiol Renal Physiol; 2012 Sep; 303(6):F831-44. PubMed ID: 22791333
[TBL] [Abstract][Full Text] [Related]
7. Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.
Filippakis H; Belaid A; Siroky B; Wu C; Alesi N; Hougard T; Nijmeh J; Lam HC; Henske EP
Sci Rep; 2018 Sep; 8(1):14161. PubMed ID: 30242175
[TBL] [Abstract][Full Text] [Related]
8. Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt's lymphoma.
Hartleben G; Müller C; Krämer A; Schimmel H; Zidek LM; Dornblut C; Winkler R; Eichwald S; Kortman G; Kosan C; Kluiver J; Petersen I; van den Berg A; Wang ZQ; Calkhoven CF
EMBO J; 2018 Nov; 37(21):. PubMed ID: 30237309
[TBL] [Abstract][Full Text] [Related]
9. mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency.
Li H; Jin F; Jiang K; Ji S; Wang L; Ni Z; Chen X; Hu Z; Zhang H; Liu Y; Qin Y; Zha X
Oncotarget; 2016 May; 7(19):28435-47. PubMed ID: 27078846
[TBL] [Abstract][Full Text] [Related]
10. Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma.
Vandewynckel YP; Coucke C; Laukens D; Devisscher L; Paridaens A; Bogaerts E; Vandierendonck A; Raevens S; Verhelst X; Van Steenkiste C; Libbrecht L; Geerts A; Van Vlierberghe H
Oncotarget; 2016 Jun; 7(23):34988-5000. PubMed ID: 27167000
[TBL] [Abstract][Full Text] [Related]
11. Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation.
Brüning A; Rahmeh M; Friese K
Mol Oncol; 2013 Dec; 7(6):1012-8. PubMed ID: 23916134
[TBL] [Abstract][Full Text] [Related]
12. Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.
Li J; Csibi A; Yang S; Hoffman GR; Li C; Zhang E; Yu JJ; Blenis J
Proc Natl Acad Sci U S A; 2015 Jan; 112(1):E21-9. PubMed ID: 25524627
[TBL] [Abstract][Full Text] [Related]
13. Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2
Jones AT; Narov K; Yang J; Sampson JR; Shen MH
Neoplasia; 2019 Feb; 21(2):230-238. PubMed ID: 30622053
[TBL] [Abstract][Full Text] [Related]
14. Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Okubo K; Isono M; Asano T; Sato A
Anticancer Res; 2018 Oct; 38(10):5615-5626. PubMed ID: 30275179
[TBL] [Abstract][Full Text] [Related]
15. Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells.
Kawabata S; Gills JJ; Mercado-Matos JR; Lopiccolo J; Wilson W; Hollander MC; Dennis PA
Cell Death Dis; 2012 Jul; 3(7):e353. PubMed ID: 22825471
[TBL] [Abstract][Full Text] [Related]
16. Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors.
Thomas S; Sharma N; Golden EB; Cho H; Agarwal P; Gaffney KJ; Petasis NA; Chen TC; Hofman FM; Louie SG; Schönthal AH
Cancer Lett; 2012 Dec; 325(1):63-71. PubMed ID: 22664238
[TBL] [Abstract][Full Text] [Related]
17. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.
Young RM; Ackerman D; Quinn ZL; Mancuso A; Gruber M; Liu L; Giannoukos DN; Bobrovnikova-Marjon E; Diehl JA; Keith B; Simon MC
Genes Dev; 2013 May; 27(10):1115-31. PubMed ID: 23699409
[TBL] [Abstract][Full Text] [Related]
18. Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways.
Pal R; Xiong Y; Sardiello M
Proc Natl Acad Sci U S A; 2019 Feb; 116(8):2977-2986. PubMed ID: 30728291
[TBL] [Abstract][Full Text] [Related]
19. Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress.
Wallington-Beddoe CT; Bennett MK; Vandyke K; Davies L; Zebol JR; Moretti PAB; Pitman MR; Hewett DR; Zannettino ACW; Pitson SM
Oncotarget; 2017 Jul; 8(27):43602-43616. PubMed ID: 28467788
[TBL] [Abstract][Full Text] [Related]
20. Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
Krishnamoorthy J; Tenkerian C; Gupta J; Ghaddar N; Wang S; Darini C; Staschke KA; Ghosh A; Gandin V; Topisirovic I; Kristof AS; Hatzoglou M; Simos G; Koromilas AE
Cell Death Dis; 2018 Feb; 9(3):254. PubMed ID: 29449538
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
