BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 29981919)

  • 1. The cardenolides strophanthidin, digoxigenin and dihydroouabain act as activators of the human RORγ/RORγT receptors.
    Karaś K; Sałkowska A; Walczak-Drzewiecka A; Ryba K; Dastych J; Bachorz RA; Ratajewski M
    Toxicol Lett; 2018 Oct; 295():314-324. PubMed ID: 29981919
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT.
    Karaś K; Sałkowska A; Karwaciak I; Walczak-Drzewiecka A; Dastych J; Bachorz RA; Ratajewski M
    Int J Mol Sci; 2019 Nov; 20(22):. PubMed ID: 31744223
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo.
    Takeda Y; Kang HS; Angers M; Jetten AM
    Nucleic Acids Res; 2011 Jun; 39(11):4769-82. PubMed ID: 21317191
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ.
    Olsson RI; Xue Y; von Berg S; Aagaard A; McPheat J; Hansson EL; Bernström J; Hansson P; Jirholt J; Grindebacke H; Leffler A; Chen R; Xiong Y; Ge H; Hansson TG; Narjes F
    ChemMedChem; 2016 Jan; 11(2):207-16. PubMed ID: 26553345
    [TBL] [Abstract][Full Text] [Related]  

  • 5. RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.
    Slominski AT; Kim TK; Takeda Y; Janjetovic Z; Brozyna AA; Skobowiat C; Wang J; Postlethwaite A; Li W; Tuckey RC; Jetten AM
    FASEB J; 2014 Jul; 28(7):2775-89. PubMed ID: 24668754
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.
    Kojima H; Takeda Y; Muromoto R; Takahashi M; Hirao T; Takeuchi S; Jetten AM; Matsuda T
    Toxicology; 2015 Mar; 329():32-9. PubMed ID: 25583575
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor γ (RORγ) by a class of aryl amide compounds.
    Zhang W; Zhang J; Fang L; Zhou L; Wang S; Xiang Z; Li Y; Wisely B; Zhang G; An G; Wang Y; Leung S; Zhong Z
    Mol Pharmacol; 2012 Oct; 82(4):583-90. PubMed ID: 22700697
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation.
    Song Y; Xue X; Wu X; Wang R; Xing Y; Yan W; Zhou Y; Qian CN; Zhang Y; Xu Y
    Eur J Med Chem; 2016 Jun; 116():13-26. PubMed ID: 27043267
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis.
    Ruan Q; Kameswaran V; Zhang Y; Zheng S; Sun J; Wang J; DeVirgiliis J; Liou HC; Beg AA; Chen YH
    J Exp Med; 2011 Oct; 208(11):2321-33. PubMed ID: 22006976
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
    Guendisch U; Weiss J; Ecoeur F; Riker JC; Kaupmann K; Kallen J; Hintermann S; Orain D; Dawson J; Billich A; Guntermann C
    PLoS One; 2017; 12(11):e0188391. PubMed ID: 29155882
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Recent progress on nuclear receptor RORγ modulators.
    Cyr P; Bronner SM; Crawford JJ
    Bioorg Med Chem Lett; 2016 Sep; 26(18):4387-4393. PubMed ID: 27542308
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of novel quinazolinedione derivatives as RORγt inverse agonist.
    Fukase Y; Sato A; Tomata Y; Ochida A; Kono M; Yonemori K; Koga K; Okui T; Yamasaki M; Fujitani Y; Nakagawa H; Koyama R; Nakayama M; Skene R; Sang BC; Hoffman I; Shirai J; Yamamoto S
    Bioorg Med Chem; 2018 Feb; 26(3):721-736. PubMed ID: 29342416
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol).
    Wang Y; Kumar N; Crumbley C; Griffin PR; Burris TP
    Biochim Biophys Acta; 2010 Aug; 1801(8):917-23. PubMed ID: 20211758
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Digoxin, an Overlooked Agonist of RORγ/RORγT.
    Karaś K; Sałkowska A; Sobalska-Kwapis M; Walczak-Drzewiecka A; Strapagiel D; Dastych J; Bachorz RA; Ratajewski M
    Front Pharmacol; 2018; 9():1460. PubMed ID: 30666196
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Clock-dependent and independent transcriptional control of the two isoforms from the mouse Rorgamma gene.
    Mongrain V; Ruan X; Dardente H; Fortier EE; Cermakian N
    Genes Cells; 2008 Dec; 13(12):1197-210. PubMed ID: 19076641
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
    Skepner J; Ramesh R; Trocha M; Schmidt D; Baloglu E; Lobera M; Carlson T; Hill J; Orband-Miller LA; Barnes A; Boudjelal M; Sundrud M; Ghosh S; Yang J
    J Immunol; 2014 Mar; 192(6):2564-75. PubMed ID: 24516202
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
    Marcotte DJ; Liu Y; Little K; Jones JH; Powell NA; Wildes CP; Silvian LF; Chodaparambil JV
    BMC Struct Biol; 2016 Jun; 16(1):7. PubMed ID: 27246200
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity.
    Pastwińska J; Karaś K; Sałkowska A; Karwaciak I; Chałaśkiewicz K; Wojtczak BA; Bachorz RA; Ratajewski M
    Int J Mol Sci; 2022 Feb; 23(3):. PubMed ID: 35163824
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.
    Narjes F; Xue Y; von Berg S; Malmberg J; Llinas A; Olsson RI; Jirholt J; Grindebacke H; Leffler A; Hossain N; Lepistö M; Thunberg L; Leek H; Aagaard A; McPheat J; Hansson EL; Bäck E; Tångefjord S; Chen R; Xiong Y; Hongbin G; Hansson TG
    J Med Chem; 2018 Sep; 61(17):7796-7813. PubMed ID: 30095900
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation.
    Lin YC; Lin YC; Wu CC; Huang MY; Tsai WC; Hung CH; Kuo PL
    Oncotarget; 2017 Jan; 8(5):7559-7571. PubMed ID: 27926504
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.