114 related articles for article (PubMed ID: 29986189)
1. Design and Amberlyst-15 mediated synthesis of novel thienyl-pyrazole carboxamides that potently inhibit Phospholipase A2 by binding to an allosteric site on the enzyme.
Kumar AD; Prabhudeva MG; Bharath S; Kumara K; Lokanath NK; Kumar KA
Bioorg Chem; 2018 Oct; 80():444-452. PubMed ID: 29986189
[TBL] [Abstract][Full Text] [Related]
2. Design and environmentally benign synthesis of novel thiophene appended pyrazole analogues as anti-inflammatory and radical scavenging agents: Crystallographic, in silico modeling, docking and SAR characterization.
Prabhudeva MG; Bharath S; Kumar AD; Naveen S; Lokanath NK; Mylarappa BN; Kumar KA
Bioorg Chem; 2017 Aug; 73():109-120. PubMed ID: 28648923
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of novel 2-pyrazoline analogues with potent anti-inflammatory effect mediated by inhibition of phospholipase A2: Crystallographic, in silico docking and QSAR analysis.
Lokeshwari DM; Achutha DK; Srinivasan B; Shivalingegowda N; Krishnappagowda LN; Kariyappa AK
Bioorg Med Chem Lett; 2017 Aug; 27(16):3806-3811. PubMed ID: 28676270
[TBL] [Abstract][Full Text] [Related]
4. A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A2.
Anilkumar NC; Sundaram MS; Mohan CD; Rangappa S; Bulusu KC; Fuchs JE; Girish KS; Bender A; Basappa ; Rangappa KS
PLoS One; 2015; 10(7):e0131896. PubMed ID: 26196520
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis of novel furan appended benzothiazepine derivatives and in vitro biological evaluation as potent VRV-PL-8a and H
Lokeshwari DM; Rekha ND; Srinivasan B; Vivek HK; Kariyappa AK
Bioorg Med Chem Lett; 2017 Jul; 27(14):3048-3054. PubMed ID: 28554871
[TBL] [Abstract][Full Text] [Related]
6. Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution.
Singh N; Jabeen T; Sharma S; Somvanshi RK; Dey S; Srinivasan A; Singh TP
Acta Crystallogr D Biol Crystallogr; 2006 Apr; 62(Pt 4):410-6. PubMed ID: 16552142
[TBL] [Abstract][Full Text] [Related]
7. Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations.
Vasilakaki S; Barbayianni E; Leonis G; Papadopoulos MG; Mavromoustakos T; Gelb MH; Kokotos G
Bioorg Med Chem; 2016 Apr; 24(8):1683-95. PubMed ID: 26970660
[TBL] [Abstract][Full Text] [Related]
8. Pyrazole-hydrazone derivatives as anti-inflammatory agents: Design, synthesis, biological evaluation, COX-1,2/5-LOX inhibition and docking study.
Abdelgawad MA; Labib MB; Abdel-Latif M
Bioorg Chem; 2017 Oct; 74():212-220. PubMed ID: 28865292
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, characterization and in vitro and in vivo anti-inflammatory evaluation of novel pyrazole-based chalcones.
Chavan HV; Adsul LK; Kotmale AS; Dhakane VD; Thakare VN; Bandgar BP
J Enzyme Inhib Med Chem; 2015 Feb; 30(1):22-31. PubMed ID: 24666306
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of some oxadiazolyl, thiadiazolyl, thiazolidinyl, and thiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
Farghaly AA; Bekhit AA; Park JY
Arch Pharm (Weinheim); 2000 Mar; 333(2-3):53-7. PubMed ID: 10783518
[TBL] [Abstract][Full Text] [Related]
11. Targeting human secretory phospholipase A2 with designed peptide inhibitors for inflammatory therapy.
Wang P; Li Y; Shao Q; Zhou W; Wang K
J Drug Target; 2015 Feb; 23(2):140-6. PubMed ID: 25237841
[TBL] [Abstract][Full Text] [Related]
12. Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.
Bukhari SN; Lauro G; Jantan I; Bifulco G; Amjad MW
Bioorg Med Chem; 2014 Aug; 22(15):4151-61. PubMed ID: 24938495
[TBL] [Abstract][Full Text] [Related]
13. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A
Kim RR; Malde AK; Nematollahi A; Scott KF; Church WB
Proteins; 2017 May; 85(5):827-842. PubMed ID: 28056488
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.
Tewari AK; Singh VP; Yadav P; Gupta G; Singh A; Goel RK; Shinde P; Mohan CG
Bioorg Chem; 2014 Oct; 56():8-15. PubMed ID: 24893208
[TBL] [Abstract][Full Text] [Related]
15. Discovery of novel secretory phospholipase A2 inhibitors using virtual screen.
Qiu S; Chen F; Liu Y; Lai L
Chem Biol Drug Des; 2014 Aug; 84(2):216-22. PubMed ID: 24612767
[TBL] [Abstract][Full Text] [Related]
16. Structures and binding studies of the complexes of phospholipase A2 with five inhibitors.
Shukla PK; Gautam L; Sinha M; Kaur P; Sharma S; Singh TP
Biochim Biophys Acta; 2015 Apr; 1854(4):269-77. PubMed ID: 25541253
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, cyclooxygenase inhibition and biological evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing amino/methanesulfonyl pharmacophore.
Abdellatif KR; Fadaly WA
Bioorg Chem; 2017 Feb; 70():57-66. PubMed ID: 27894776
[TBL] [Abstract][Full Text] [Related]
18. Design and synthesis of some substituted 1H-pyrazolyl-oxazolidines or 1H-pyrazolyl-thiazolidines as anti-inflammatory-antimicrobial agents.
Bekhit AA; Fahmy HT
Arch Pharm (Weinheim); 2003 Apr; 336(2):111-8. PubMed ID: 12761764
[TBL] [Abstract][Full Text] [Related]
19. Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues.
Alam MJ; Alam O; Khan SA; Naim MJ; Islamuddin M; Deora GS
Drug Des Devel Ther; 2016; 10():3529-3543. PubMed ID: 27826185
[TBL] [Abstract][Full Text] [Related]
20. Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.
Chen H; Knerr L; Åkerud T; Hallberg K; Öster L; Rohman M; Österlund K; Beisel HG; Olsson T; Brengdhal J; Sandmark J; Bodin C
Bioorg Med Chem Lett; 2014 Nov; 24(22):5251-5. PubMed ID: 25316315
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]