BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 29989390)

  • 1. Engineered Flumazenil Recognition Site Provides Mechanistic Insight Governing Benzodiazepine Modulation in GABA
    Siebert DCB; Bampali K; Puthenkalam R; Varagic Z; Sarto-Jackson I; Scholze P; Sieghart W; Mihovilovic MD; Schnürch M; Ernst M
    ACS Chem Biol; 2018 Aug; 13(8):2040-2047. PubMed ID: 29989390
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA
    McGrath M; Hoyt H; Pence A; Forman SA; Raines DE
    Br J Pharmacol; 2021 Dec; 178(24):4842-4858. PubMed ID: 34386973
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.
    Middendorp SJ; Maldifassi MC; Baur R; Sigel E
    Neuropharmacology; 2015 Aug; 95():459-67. PubMed ID: 25963418
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABA
    Söderhielm PC; Balle T; Bak-Nyhus S; Zhang M; Hansen KM; Ahring PK; Jensen AA
    Biochem Pharmacol; 2018 Dec; 158():339-358. PubMed ID: 30121248
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.
    Wallner M; Hanchar HJ; Olsen RW
    Neurochem Res; 2014 Jun; 39(6):1118-26. PubMed ID: 24500446
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.
    Wingrove PB; Thompson SA; Wafford KA; Whiting PJ
    Mol Pharmacol; 1997 Nov; 52(5):874-81. PubMed ID: 9351978
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface.
    Che Has AT; Absalom N; van Nieuwenhuijzen PS; Clarkson AN; Ahring PK; Chebib M
    Sci Rep; 2016 Jun; 6():28674. PubMed ID: 27346730
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation.
    Leppä E; Linden AM; Rabe H; Vekovischeva OY; Wulff P; Lüddens H; Wisden W; Korpi ER
    Eur J Pharmacol; 2011 Sep; 666(1-3):111-21. PubMed ID: 21616065
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site.
    Buhr A; Baur R; Sigel E
    J Biol Chem; 1997 May; 272(18):11799-804. PubMed ID: 9115236
    [TBL] [Abstract][Full Text] [Related]  

  • 10. GABA
    Müller Herde A; Benke D; Ralvenius WT; Mu L; Schibli R; Zeilhofer HU; Krämer SD
    Neuroimage; 2017 Apr; 150():279-291. PubMed ID: 28192273
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs.
    Ramerstorfer J; Furtmüller R; Sarto-Jackson I; Varagic Z; Sieghart W; Ernst M
    J Neurosci; 2011 Jan; 31(3):870-7. PubMed ID: 21248110
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
    Whittemore ER; Yang W; Drewe JA; Woodward RM
    Mol Pharmacol; 1996 Nov; 50(5):1364-75. PubMed ID: 8913369
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABA
    Fabjan J; Koniuszewski F; Schaar B; Ernst M
    Front Neurosci; 2020; 14():611953. PubMed ID: 33519364
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Different Benzodiazepines Bind with Distinct Binding Modes to GABA
    Elgarf AA; Siebert DCB; Steudle F; Draxler A; Li G; Huang S; Cook JM; Ernst M; Scholze P
    ACS Chem Biol; 2018 Aug; 13(8):2033-2039. PubMed ID: 29767950
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Residues at positions 206 and 209 of the alpha1 subunit of gamma-aminobutyric AcidA receptors influence affinities for benzodiazepine binding site ligands.
    Buhr A; Schaerer MT; Baur R; Sigel E
    Mol Pharmacol; 1997 Oct; 52(4):676-82. PubMed ID: 9380031
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Benzodiazepine Ligand with Improved GABA
    Simeone X; Koniuszewski F; Müllegger M; Smetka A; Steudle F; Puthenkalam R; Ernst M; Scholze P
    Mol Pharmacol; 2021 Jan; 99(1):39-48. PubMed ID: 33268553
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R; Tan KR; Lüscher BP; Gonthier A; Goeldner M; Sigel E
    J Neurochem; 2008 Sep; 106(6):2353-63. PubMed ID: 18643789
    [TBL] [Abstract][Full Text] [Related]  

  • 18. GABA
    Iorio MT; Vogel FD; Koniuszewski F; Scholze P; Rehman S; Simeone X; Schnürch M; Mihovilovic MD; Ernst M
    Int J Mol Sci; 2020 Jan; 21(1):. PubMed ID: 31947863
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Defined concatenated α6α1β3γ2 GABA
    Simeone X; Iorio MT; Siebert DCB; Rehman S; Schnürch M; Mihovilovic MD; Ernst M
    Bioorg Med Chem; 2019 Jul; 27(14):3167-3178. PubMed ID: 31186146
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces.
    Sharkey LM; Czajkowski C
    Mol Pharmacol; 2008 Jul; 74(1):203-12. PubMed ID: 18424553
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.