139 related articles for article (PubMed ID: 29989390)
21. Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators.
Tan KR; Gonthier A; Baur R; Ernst M; Goeldner M; Sigel E
J Biol Chem; 2007 Sep; 282(36):26316-25. PubMed ID: 17626010
[TBL] [Abstract][Full Text] [Related]
22. Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors.
Amin J; Brooks-Kayal A; Weiss DS
Mol Pharmacol; 1997 May; 51(5):833-41. PubMed ID: 9145922
[TBL] [Abstract][Full Text] [Related]
23. Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands.
Kelly MD; Smith A; Banks G; Wingrove P; Whiting PW; Atack J; Seabrook GR; Maubach KA
Br J Pharmacol; 2002 Jan; 135(1):248-56. PubMed ID: 11786501
[TBL] [Abstract][Full Text] [Related]
24. Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.
Richter L; de Graaf C; Sieghart W; Varagic Z; Mörzinger M; de Esch IJ; Ecker GF; Ernst M
Nat Chem Biol; 2012 Mar; 8(5):455-64. PubMed ID: 22446838
[TBL] [Abstract][Full Text] [Related]
25. A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity.
Buhr A; Sigel E
Proc Natl Acad Sci U S A; 1997 Aug; 94(16):8824-9. PubMed ID: 9238062
[TBL] [Abstract][Full Text] [Related]
26. Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
Casula MA; Bromidge FA; Pillai GV; Wingrove PB; Martin K; Maubach K; Seabrook GR; Whiting PJ; Hadingham KL
J Neurochem; 2001 Apr; 77(2):445-51. PubMed ID: 11299307
[TBL] [Abstract][Full Text] [Related]
27. Novel positive allosteric modulators of GABAA receptors with anesthetic activity.
Maldifassi MC; Baur R; Pierce D; Nourmahnad A; Forman SA; Sigel E
Sci Rep; 2016 May; 6():25943. PubMed ID: 27198062
[TBL] [Abstract][Full Text] [Related]
28. Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.
Tan KR; Baur R; Gonthier A; Goeldner M; Sigel E
FEBS Lett; 2007 Oct; 581(24):4718-22. PubMed ID: 17854801
[TBL] [Abstract][Full Text] [Related]
29. α subunits in GABA
Wongsamitkul N; Maldifassi MC; Simeone X; Baur R; Ernst M; Sigel E
Sci Rep; 2017 Nov; 7(1):15498. PubMed ID: 29138471
[TBL] [Abstract][Full Text] [Related]
30. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface.
Varagic Z; Wimmer L; Schnürch M; Mihovilovic MD; Huang S; Rallapalli S; Cook JM; Mirheydari P; Ecker GF; Sieghart W; Ernst M
Br J Pharmacol; 2013 May; 169(2):371-83. PubMed ID: 23472852
[TBL] [Abstract][Full Text] [Related]
31. Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors.
Varagic Z; Ramerstorfer J; Huang S; Rallapalli S; Sarto-Jackson I; Cook J; Sieghart W; Ernst M
Br J Pharmacol; 2013 May; 169(2):384-99. PubMed ID: 23472935
[TBL] [Abstract][Full Text] [Related]
32. A closer look at the high affinity benzodiazepine binding site on GABAA receptors.
Sigel E; Lüscher BP
Curr Top Med Chem; 2011; 11(2):241-6. PubMed ID: 21189125
[TBL] [Abstract][Full Text] [Related]
33. Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site.
Buhr A; Baur R; Malherbe P; Sigel E
Mol Pharmacol; 1996 Jun; 49(6):1080-4. PubMed ID: 8649346
[TBL] [Abstract][Full Text] [Related]
34. Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.
Tan KR; Baur R; Charon S; Goeldner M; Sigel E
J Neurochem; 2009 Dec; 111(5):1264-73. PubMed ID: 19804380
[TBL] [Abstract][Full Text] [Related]
35. Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
Korpi ER; Seeburg PH
Eur J Pharmacol; 1993 Sep; 247(1):23-7. PubMed ID: 8258357
[TBL] [Abstract][Full Text] [Related]
36. Relative positioning of classical benzodiazepines to the γ2-subunit of GABAA receptors.
Middendorp SJ; Hurni E; Schönberger M; Stein M; Pangerl M; Trauner D; Sigel E
ACS Chem Biol; 2014 Aug; 9(8):1846-53. PubMed ID: 24918742
[TBL] [Abstract][Full Text] [Related]
37. Structural elements of the gamma-aminobutyric acid type A receptor conferring subtype selectivity for benzodiazepine site ligands.
Renard S; Olivier A; Granger P; Avenet P; Graham D; Sevrin M; George P; Besnard F
J Biol Chem; 1999 May; 274(19):13370-4. PubMed ID: 10224099
[TBL] [Abstract][Full Text] [Related]
38. The benzodiazepine binding pocket of recombinant alpha1beta2gamma2 gamma-aminobutyric acidA receptors: relative orientation of ligands and amino acid side chains.
Sigel E; Schaerer MT; Buhr A; Baur R
Mol Pharmacol; 1998 Dec; 54(6):1097-105. PubMed ID: 9855639
[TBL] [Abstract][Full Text] [Related]
39. Endogenous ligands of benzodiazepine binding site have inverse agonistic properties.
Sliva J; Hess L; Votava M; Malek J
Med Hypotheses; 2013 Dec; 81(6):1075-7. PubMed ID: 24183322
[TBL] [Abstract][Full Text] [Related]
40. On the benzodiazepine binding pocket in GABAA receptors.
Berezhnoy D; Nyfeler Y; Gonthier A; Schwob H; Goeldner M; Sigel E
J Biol Chem; 2004 Jan; 279(5):3160-8. PubMed ID: 14612433
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
