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5. Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin. Caulfield TR; Fiesel FC; Moussaud-Lamodière EL; Dourado DF; Flores SC; Springer W PLoS Comput Biol; 2014 Nov; 10(11):e1003935. PubMed ID: 25375667 [TBL] [Abstract][Full Text] [Related]
6. A Ubl/ubiquitin switch in the activation of Parkin. Sauvé V; Lilov A; Seirafi M; Vranas M; Rasool S; Kozlov G; Sprules T; Wang J; Trempe JF; Gehring K EMBO J; 2015 Oct; 34(20):2492-505. PubMed ID: 26254305 [TBL] [Abstract][Full Text] [Related]
7. Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation. Aguirre JD; Dunkerley KM; Mercier P; Shaw GS Proc Natl Acad Sci U S A; 2017 Jan; 114(2):298-303. PubMed ID: 28007983 [TBL] [Abstract][Full Text] [Related]
8. Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity. Ham SJ; Lee SY; Song S; Chung JR; Choi S; Chung J J Biol Chem; 2016 Jan; 291(4):1803-1816. PubMed ID: 26631732 [TBL] [Abstract][Full Text] [Related]
9. Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in Lenka DR; Dahe SV; Antico O; Sahoo P; Prescott AR; Muqit MMK; Kumar A Elife; 2024 Sep; 13():. PubMed ID: 39221915 [TBL] [Abstract][Full Text] [Related]
10. Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation. Tang MY; Vranas M; Krahn AI; Pundlik S; Trempe JF; Fon EA Nat Commun; 2017 Mar; 8():14697. PubMed ID: 28276439 [TBL] [Abstract][Full Text] [Related]
12. Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin. Aguirre JD; Dunkerley KM; Lam R; Rusal M; Shaw GS J Biol Chem; 2018 Apr; 293(17):6337-6348. PubMed ID: 29530980 [TBL] [Abstract][Full Text] [Related]
13. Structural basis for feedforward control in the PINK1/Parkin pathway. Sauvé V; Sung G; MacDougall EJ; Kozlov G; Saran A; Fakih R; Fon EA; Gehring K EMBO J; 2022 Jun; 41(12):e109460. PubMed ID: 35491809 [TBL] [Abstract][Full Text] [Related]
15. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Kazlauskaite A; Kondapalli C; Gourlay R; Campbell DG; Ritorto MS; Hofmann K; Alessi DR; Knebel A; Trost M; Muqit MM Biochem J; 2014 May; 460(1):127-39. PubMed ID: 24660806 [TBL] [Abstract][Full Text] [Related]
16. Activation of parkin by a molecular glue. Sauvé V; Stefan E; Croteau N; Goiran T; Fakih R; Bansal N; Hadzipasic A; Fang J; Murugan P; Chen S; Fon EA; Hirst WD; Silvian LF; Trempe JF; Gehring K Nat Commun; 2024 Sep; 15(1):7707. PubMed ID: 39300082 [TBL] [Abstract][Full Text] [Related]
17. Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation. Liu JY; Inoshita T; Shiba-Fukushima K; Yoshida S; Ogata K; Ishihama Y; Imai Y; Hattori N Hum Mol Genet; 2022 Aug; 31(15):2623-2638. PubMed ID: 35313349 [TBL] [Abstract][Full Text] [Related]
18. Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL. Koyano F; Yamano K; Kosako H; Tanaka K; Matsuda N J Biol Chem; 2019 Jun; 294(26):10300-10314. PubMed ID: 31110043 [No Abstract] [Full Text] [Related]
19. Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria. Vranas M; Lu Y; Rasool S; Croteau N; Krett JD; Sauvé V; Gehring K; Fon EA; Durcan TM; Trempe JF Open Biol; 2022 Jan; 12(1):210255. PubMed ID: 35042405 [TBL] [Abstract][Full Text] [Related]
20. Structure of PINK1 in complex with its substrate ubiquitin. Schubert AF; Gladkova C; Pardon E; Wagstaff JL; Freund SMV; Steyaert J; Maslen SL; Komander D Nature; 2017 Dec; 552(7683):51-56. PubMed ID: 29160309 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]