These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

366 related articles for article (PubMed ID: 29995851)

  • 1. Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
    Qi X; Schmiege P; Coutavas E; Wang J; Li X
    Nature; 2018 Aug; 560(7716):128-132. PubMed ID: 29995851
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
    Qi X; Schmiege P; Coutavas E; Li X
    Science; 2018 Oct; 362(6410):. PubMed ID: 30139912
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
    Qian H; Cao P; Hu M; Gao S; Yan N; Gong X
    Nat Commun; 2019 May; 10(1):2320. PubMed ID: 31127104
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis of sterol recognition by human hedgehog receptor PTCH1.
    Qi C; Di Minin G; Vercellino I; Wutz A; Korkhov VM
    Sci Adv; 2019 Sep; 5(9):eaaw6490. PubMed ID: 31555730
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for the recognition of Sonic Hedgehog by human Patched1.
    Gong X; Qian H; Cao P; Zhao X; Zhou Q; Lei J; Yan N
    Science; 2018 Aug; 361(6402):. PubMed ID: 29954986
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
    Rudolf AF; Kinnebrew M; Kowatsch C; Ansell TB; El Omari K; Bishop B; Pardon E; Schwab RA; Malinauskas T; Qian M; Duman R; Covey DF; Steyaert J; Wagner A; Sansom MSP; Rohatgi R; Siebold C
    Nat Chem Biol; 2019 Oct; 15(10):975-982. PubMed ID: 31548691
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.
    Fleet AJ; Hamel PA
    J Biol Chem; 2018 Oct; 293(43):16583-16595. PubMed ID: 30166346
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling.
    Fleet A; Lee JP; Tamachi A; Javeed I; Hamel PA
    J Biol Chem; 2016 Aug; 291(34):17557-68. PubMed ID: 27325696
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expression, Purification, and Structure Determination of Human PTCH1-HH-N Complexes.
    Qi X; Schmiege P; Esparza L; Li X
    Methods Mol Biol; 2022; 2374():107-120. PubMed ID: 34562247
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distinct effects of the mesenchymal dysplasia gene variant of murine Patched-1 protein on canonical and non-canonical Hedgehog signaling pathways.
    Harvey MC; Fleet A; Okolowsky N; Hamel PA
    J Biol Chem; 2014 Apr; 289(15):10939-10949. PubMed ID: 24570001
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
    Griffiths SC; Schwab RA; El Omari K; Bishop B; Iverson EJ; Malinauskas T; Dubey R; Qian M; Covey DF; Gilbert RJC; Rohatgi R; Siebold C
    Nat Commun; 2021 Dec; 12(1):7171. PubMed ID: 34887403
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification and characterization of two novel PTCH1 splice variants.
    Yu P; Yang J; Zhang Y
    Biochem Biophys Res Commun; 2017 May; 487(1):68-75. PubMed ID: 28390897
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling.
    Chang H; Li Q; Moraes RC; Lewis MT; Hamel PA
    Int J Biochem Cell Biol; 2010 Sep; 42(9):1462-71. PubMed ID: 20451654
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Distinct roles of PTCH2 splice variants in Hedgehog signalling.
    Rahnama F; Toftgård R; Zaphiropoulos PG
    Biochem J; 2004 Mar; 378(Pt 2):325-34. PubMed ID: 14613484
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling.
    Qi X; Li X
    Trends Biochem Sci; 2020 May; 45(5):397-410. PubMed ID: 32311334
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.
    Kowatsch C; Woolley RE; Kinnebrew M; Rohatgi R; Siebold C
    Curr Opin Struct Biol; 2019 Aug; 57():204-214. PubMed ID: 31247512
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
    Zhang Y; Bulkley DP; Xin Y; Roberts KJ; Asarnow DE; Sharma A; Myers BR; Cho W; Cheng Y; Beachy PA
    Cell; 2018 Nov; 175(5):1352-1364.e14. PubMed ID: 30415841
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.
    Bijlsma MF; Spek CA; Zivkovic D; van de Water S; Rezaee F; Peppelenbosch MP
    PLoS Biol; 2006 Jul; 4(8):e232. PubMed ID: 16895439
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.
    Tukachinsky H; Petrov K; Watanabe M; Salic A
    Proc Natl Acad Sci U S A; 2016 Oct; 113(40):E5866-E5875. PubMed ID: 27647915
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cholesterol access in cellular membranes controls Hedgehog signaling.
    Radhakrishnan A; Rohatgi R; Siebold C
    Nat Chem Biol; 2020 Dec; 16(12):1303-1313. PubMed ID: 33199907
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.