BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

228 related articles for article (PubMed ID: 30004670)

  • 1. Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.
    Counihan JL; Wiggenhorn AL; Anderson KE; Nomura DK
    ACS Chem Biol; 2018 Aug; 13(8):1970-1977. PubMed ID: 30004670
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.
    Bateman LA; Nguyen TB; Roberts AM; Miyamoto DK; Ku WM; Huffman TR; Petri Y; Heslin MJ; Contreras CM; Skibola CF; Olzmann JA; Nomura DK
    Chem Commun (Camb); 2017 Jun; 53(53):7234-7237. PubMed ID: 28352901
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target.
    Roberts AM; Miyamoto DK; Huffman TR; Bateman LA; Ives AN; Akopian D; Heslin MJ; Contreras CM; Rape M; Skibola CF; Nomura DK
    ACS Chem Biol; 2017 Apr; 12(4):899-904. PubMed ID: 28186401
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity.
    Anderson KE; To M; Olzmann JA; Nomura DK
    ACS Chem Biol; 2017 Oct; 12(10):2522-2528. PubMed ID: 28892616
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.
    Parajuli B; Georgiadis TM; Fishel ML; Hurley TD
    Chembiochem; 2014 Mar; 15(5):701-12. PubMed ID: 24677340
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.
    Grossman EA; Ward CC; Spradlin JN; Bateman LA; Huffman TR; Miyamoto DK; Kleinman JI; Nomura DK
    Cell Chem Biol; 2017 Nov; 24(11):1368-1376.e4. PubMed ID: 28919038
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.
    Koundinya M; Sudhalter J; Courjaud A; Lionne B; Touyer G; Bonnet L; Menguy I; Schreiber I; Perrault C; Vougier S; Benhamou B; Zhang B; He T; Gao Q; Gee P; Simard D; Castaldi MP; Tomlinson R; Reiling S; Barrague M; Newcombe R; Cao H; Wang Y; Sun F; Murtie J; Munson M; Yang E; Harper D; Bouaboula M; Pollard J; Grepin C; Garcia-Echeverria C; Cheng H; Adrian F; Winter C; Licht S; Cornella-Taracido I; Arrebola R; Morris A
    Cell Chem Biol; 2018 Jun; 25(6):705-717.e11. PubMed ID: 29628435
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
    Johansson H; Isabella Tsai YC; Fantom K; Chung CW; Kümper S; Martino L; Thomas DA; Eberl HC; Muelbaier M; House D; Rittinger K
    J Am Chem Soc; 2019 Feb; 141(6):2703-2712. PubMed ID: 30657686
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity.
    Roberts LS; Yan P; Bateman LA; Nomura DK
    ACS Chem Biol; 2017 Apr; 12(4):1133-1140. PubMed ID: 28248089
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.
    Parajuli B; Fishel ML; Hurley TD
    J Med Chem; 2014 Jan; 57(2):449-61. PubMed ID: 24387105
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity.
    Jang JH; Bruse S; Liu Y; Duffy V; Zhang C; Oyamada N; Randell S; Matsumoto A; Thompson DC; Lin Y; Vasiliou V; Tesfaigzi Y; Nyunoya T
    Free Radic Biol Med; 2014 Mar; 68():80-6. PubMed ID: 24316006
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB.
    King EA; Cho Y; Hsu NS; Dovala D; McKenna JM; Tallarico JA; Schirle M; Nomura DK
    Cell Chem Biol; 2023 Apr; 30(4):394-402.e9. PubMed ID: 36898369
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.
    Jiménez R; Pequerul R; Amor A; Lorenzo J; Metwally K; Avilés FX; Parés X; Farrés J
    Chem Biol Interact; 2019 Jun; 306():123-130. PubMed ID: 30958995
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.
    Shah CP; Kharkar PS
    Eur J Med Chem; 2018 Oct; 158():286-301. PubMed ID: 30223117
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.
    Khanna M; Chen CH; Kimble-Hill A; Parajuli B; Perez-Miller S; Baskaran S; Kim J; Dria K; Vasiliou V; Mochly-Rosen D; Hurley TD
    J Biol Chem; 2011 Dec; 286(50):43486-94. PubMed ID: 22021038
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cationic and Neutral N-Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI-60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation.
    Zhang C; Hemmert C; Gornitzka H; Cuvillier O; Zhang M; Sun RW
    ChemMedChem; 2018 Jun; 13(12):1218-1229. PubMed ID: 29603648
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics.
    Zhang W; Hu X; Chakravarty H; Yang Z; Tam KY
    ACS Comb Sci; 2018 Nov; 20(11):660-671. PubMed ID: 30350563
    [TBL] [Abstract][Full Text] [Related]  

  • 18. ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis.
    Koppaka V; Chen Y; Mehta G; Orlicky DJ; Thompson DC; Jester JV; Vasiliou V
    PLoS One; 2016; 11(1):e0146433. PubMed ID: 26751691
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma.
    De Monte C; Carradori S; Secci D; D'Ascenzio M; Guglielmi P; Mollica A; Morrone S; Scarpa S; Aglianò AM; Giantulli S; Silvestri I
    Eur J Med Chem; 2015 Nov; 105():245-62. PubMed ID: 26498571
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aldehyde dehydrogenases and cell proliferation.
    Muzio G; Maggiora M; Paiuzzi E; Oraldi M; Canuto RA
    Free Radic Biol Med; 2012 Feb; 52(4):735-46. PubMed ID: 22206977
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.