182 related articles for article (PubMed ID: 30006371)
1. Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity.
Li AP; Alam N; Amaral K; Ho MD; Loretz C; Mitchell W; Yang Q
Drug Metab Dispos; 2018 Nov; 46(11):1562-1571. PubMed ID: 30006371
[TBL] [Abstract][Full Text] [Related]
2. Inter-individual and inter-regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors.
Li AP; Ho MD; Alam N; Mitchell W; Wong S; Yan Z; Kenny JR; E C A Hop C
Pharmacol Res Perspect; 2020 Oct; 8(5):e00645. PubMed ID: 32851819
[TBL] [Abstract][Full Text] [Related]
3. In Vitro Human Cell-Based Experimental Models for the Evaluation of Enteric Metabolism and Drug Interaction Potential of Drugs and Natural Products.
Li AP
Drug Metab Dispos; 2020 Oct; 48(10):980-992. PubMed ID: 32636209
[TBL] [Abstract][Full Text] [Related]
4. A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes).
Li AP; Ho MD; Amaral K; Loretz C
Drug Metab Dispos; 2018 Nov; 46(11):1608-1616. PubMed ID: 29363498
[TBL] [Abstract][Full Text] [Related]
5. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential.
Li AP; Lu C; Brent JA; Pham C; Fackett A; Ruegg CE; Silber PM
Chem Biol Interact; 1999 Jun; 121(1):17-35. PubMed ID: 10418968
[TBL] [Abstract][Full Text] [Related]
6. A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes).
Li AP; Amaral K; Ho MD
Drug Metab Lett; 2018; 12(2):132-137. PubMed ID: 30124163
[TBL] [Abstract][Full Text] [Related]
7. The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?
Doherty MM; Charman WN
Clin Pharmacokinet; 2002; 41(4):235-53. PubMed ID: 11978143
[TBL] [Abstract][Full Text] [Related]
8. Cryopreserved human hepatocytes as alternative in vitro model for cytochrome p450 induction studies.
Garcia M; Rager J; Wang Q; Strab R; Hidalgo IJ; Owen A; Li J
In Vitro Cell Dev Biol Anim; 2003; 39(7):283-7. PubMed ID: 14599235
[TBL] [Abstract][Full Text] [Related]
9. Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions.
Wong S; Doshi U; Vuong P; Liu N; Tay S; Le H; Kosaka M; Kenny JR; Li AP; Yan Z
Drug Metab Lett; 2018; 12(1):3-13. PubMed ID: 29237391
[TBL] [Abstract][Full Text] [Related]
10. Oxidative metabolism of foreign compounds in rat small intestine: cellular localization and dependence on dietary iron.
Hoensch H; Woo CH; Raffin SB; Schmid R
Gastroenterology; 1976 Jun; 70(6):1063-70. PubMed ID: 817959
[TBL] [Abstract][Full Text] [Related]
11. Phase 1 and phase 2 metabolic activities along the small intestine in adult male sheep.
Maté L; Virkel G; Lifschitz A; Sallovitz J; Ballent M; Lanusse C
J Vet Pharmacol Ther; 2010 Dec; 33(6):537-45. PubMed ID: 21062305
[TBL] [Abstract][Full Text] [Related]
12. Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions.
Galetin A; Gertz M; Houston JB
Expert Opin Drug Metab Toxicol; 2008 Jul; 4(7):909-22. PubMed ID: 18624679
[TBL] [Abstract][Full Text] [Related]
13. Cytochrome P450-mediated metabolism in the human gut wall.
Thelen K; Dressman JB
J Pharm Pharmacol; 2009 May; 61(5):541-58. PubMed ID: 19405992
[TBL] [Abstract][Full Text] [Related]
14. Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450.
Yajima K; Uno Y; Murayama N; Uehara S; Shimizu M; Nakamura C; Iwasaki K; Utoh M; Yamazaki H
Drug Metab Dispos; 2014 May; 42(5):867-71. PubMed ID: 24553381
[TBL] [Abstract][Full Text] [Related]
15. Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans.
Darwich AS; Aslam U; Ashcroft DM; Rostami-Hodjegan A
Drug Metab Dispos; 2014 Dec; 42(12):2016-22. PubMed ID: 25233858
[TBL] [Abstract][Full Text] [Related]
16. In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
Utkarsh D; Loretz C; Li AP
Chem Biol Interact; 2016 Aug; 255():12-22. PubMed ID: 26718876
[TBL] [Abstract][Full Text] [Related]
17. Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes.
Lin C; Shi J; Moore A; Khetani SR
Drug Metab Dispos; 2016 Jan; 44(1):127-36. PubMed ID: 26452722
[TBL] [Abstract][Full Text] [Related]
18. The use of human hepatocytes to investigate drug metabolism and CYP enzyme induction.
Klieber S; Torreilles F; Guillou F; Fabre G
Methods Mol Biol; 2010; 640():295-308. PubMed ID: 20645059
[TBL] [Abstract][Full Text] [Related]
19. Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro.
van de Kerkhof EG; de Graaf IA; Ungell AL; Groothuis GM
Drug Metab Dispos; 2008 Mar; 36(3):604-13. PubMed ID: 18094037
[TBL] [Abstract][Full Text] [Related]
20. Human Enterocytes as an In Vitro Model for the Evaluation of Intestinal Drug Metabolism: Characterization of Drug-Metabolizing Enzyme Activities of Cryopreserved Human Enterocytes from Twenty-Four Donors.
Ho MD; Ring N; Amaral K; Doshi U; Li AP
Drug Metab Dispos; 2017 Jun; 45(6):686-691. PubMed ID: 28396528
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
