These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
5. Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission. Yarwood RE; Imlach WL; Lieu T; Veldhuis NA; Jensen DD; Klein Herenbrink C; Aurelio L; Cai Z; Christie MJ; Poole DP; Porter CJH; McLean P; Hicks GA; Geppetti P; Halls ML; Canals M; Bunnett NW Proc Natl Acad Sci U S A; 2017 Nov; 114(46):12309-12314. PubMed ID: 29087309 [TBL] [Abstract][Full Text] [Related]
6. Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2. Valdez-Morales EE; Overington J; Guerrero-Alba R; Ochoa-Cortes F; Ibeakanma CO; Spreadbury I; Bunnett NW; Beyak M; Vanner SJ Am J Gastroenterol; 2013 Oct; 108(10):1634-43. PubMed ID: 23958521 [TBL] [Abstract][Full Text] [Related]
7. Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2. Tu NH; Jensen DD; Anderson BM; Chen E; Jimenez-Vargas NN; Scheff NN; Inoue K; Tran HD; Dolan JC; Meek TA; Hollenberg MD; Liu CZ; Vanner SJ; Janal MN; Bunnett NW; Edgington-Mitchell LE; Schmidt BL J Neurosci; 2021 Jan; 41(1):193-210. PubMed ID: 33172978 [TBL] [Abstract][Full Text] [Related]
8. Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. Zhao P; Lieu T; Barlow N; Metcalf M; Veldhuis NA; Jensen DD; Kocan M; Sostegni S; Haerteis S; Baraznenok V; Henderson I; Lindström E; Guerrero-Alba R; Valdez-Morales EE; Liedtke W; McIntyre P; Vanner SJ; Korbmacher C; Bunnett NW J Biol Chem; 2014 Sep; 289(39):27215-27234. PubMed ID: 25118282 [TBL] [Abstract][Full Text] [Related]
9. Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Jensen DD; Lieu T; Halls ML; Veldhuis NA; Imlach WL; Mai QN; Poole DP; Quach T; Aurelio L; Conner J; Herenbrink CK; Barlow N; Simpson JS; Scanlon MJ; Graham B; McCluskey A; Robinson PJ; Escriou V; Nassini R; Materazzi S; Geppetti P; Hicks GA; Christie MJ; Porter CJH; Canals M; Bunnett NW Sci Transl Med; 2017 May; 9(392):. PubMed ID: 28566424 [TBL] [Abstract][Full Text] [Related]
10. Role for protease activity in visceral pain in irritable bowel syndrome. Cenac N; Andrews CN; Holzhausen M; Chapman K; Cottrell G; Andrade-Gordon P; Steinhoff M; Barbara G; Beck P; Bunnett NW; Sharkey KA; Ferraz JG; Shaffer E; Vergnolle N J Clin Invest; 2007 Mar; 117(3):636-47. PubMed ID: 17304351 [TBL] [Abstract][Full Text] [Related]
11. Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2. Lieu T; Savage E; Zhao P; Edgington-Mitchell L; Barlow N; Bron R; Poole DP; McLean P; Lohman RJ; Fairlie DP; Bunnett NW Br J Pharmacol; 2016 Sep; 173(18):2752-65. PubMed ID: 27423137 [TBL] [Abstract][Full Text] [Related]
12. Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon. Kayssi A; Amadesi S; Bautista F; Bunnett NW; Vanner S J Physiol; 2007 May; 580(Pt.3):977-91. PubMed ID: 17289784 [TBL] [Abstract][Full Text] [Related]
13. Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane. Jensen DD; Zhao P; Jimenez-Vargas NN; Lieu T; Gerges M; Yeatman HR; Canals M; Vanner SJ; Poole DP; Bunnett NW J Biol Chem; 2016 May; 291(21):11285-99. PubMed ID: 27030010 [TBL] [Abstract][Full Text] [Related]
14. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. Grant AD; Cottrell GS; Amadesi S; Trevisani M; Nicoletti P; Materazzi S; Altier C; Cenac N; Zamponi GW; Bautista-Cruz F; Lopez CB; Joseph EK; Levine JD; Liedtke W; Vanner S; Vergnolle N; Geppetti P; Bunnett NW J Physiol; 2007 Feb; 578(Pt 3):715-33. PubMed ID: 17124270 [TBL] [Abstract][Full Text] [Related]
15. Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Stalheim L; Ding Y; Gullapalli A; Paing MM; Wolfe BL; Morris DR; Trejo J Mol Pharmacol; 2005 Jan; 67(1):78-87. PubMed ID: 15475570 [TBL] [Abstract][Full Text] [Related]
16. Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor. Déry O; Thoma MS; Wong H; Grady EF; Bunnett NW J Biol Chem; 1999 Jun; 274(26):18524-35. PubMed ID: 10373461 [TBL] [Abstract][Full Text] [Related]
17. Comparison of pancreatic enzyme abnormalities and protease-activated receptor-2-positive eosinophils in the duodenum of patients with functional dyspepsia-irritable bowel syndrome overlap with functional dyspepsia alone in Asian populations. Futagami S; Kessoku T; Kasai Y; Higurashi T; Nakajima A; Agawa S; Yamawaki H; Nakamura K; Habiro M; Kawawa R; Ueki N; Higashida S; Watanabe Y; Yamato H; Yamamoto T; Takasaki Y; Ito K; Hojo M; Isayama H; Motoda N; Ohashi R; Siah KTH; Ng CK; Gwee KA J Gastroenterol Hepatol; 2023 Oct; 38(10):1778-1786. PubMed ID: 37278449 [TBL] [Abstract][Full Text] [Related]
18. Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate. Castro J; Harrington AM; Hughes PA; Martin CM; Ge P; Shea CM; Jin H; Jacobson S; Hannig G; Mann E; Cohen MB; MacDougall JE; Lavins BJ; Kurtz CB; Silos-Santiago I; Johnston JM; Currie MG; Blackshaw LA; Brierley SM Gastroenterology; 2013 Dec; 145(6):1334-46.e1-11. PubMed ID: 23958540 [TBL] [Abstract][Full Text] [Related]