BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

361 related articles for article (PubMed ID: 30038412)

  • 1. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
    Koyuncu S; Saez I; Lee HJ; Gutierrez-Garcia R; Pokrzywa W; Fatima A; Hoppe T; Vilchez D
    Nat Commun; 2018 Jul; 9(1):2886. PubMed ID: 30038412
    [TBL] [Abstract][Full Text] [Related]  

  • 2. G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly.
    Gutiérrez-Garcia R; Koyuncu S; Hommen F; Bilican S; Lee HJ; Fatima A; Vilchez D
    Hum Mol Genet; 2023 May; 32(10):1607-1621. PubMed ID: 36611004
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Proteostasis of Huntingtin in Health and Disease.
    Koyuncu S; Fatima A; Gutierrez-Garcia R; Vilchez D
    Int J Mol Sci; 2017 Jul; 18(7):. PubMed ID: 28753941
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Juvenile Huntington's Disease Skin Fibroblasts Respond with Elevated Parkin Level and Increased Proteasome Activity as a Potential Mechanism to Counterbalance the Pathological Consequences of Mutant Huntingtin Protein.
    Aladdin A; Király R; Boto P; Regdon Z; Tar K
    Int J Mol Sci; 2019 Oct; 20(21):. PubMed ID: 31717806
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.
    Lin L; Jin Z; Tan H; Xu Q; Peng T; Li H
    Brain Res; 2016 Jul; 1643():103-12. PubMed ID: 27107943
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.
    Irmak D; Fatima A; Gutiérrez-Garcia R; Rinschen MM; Wagle P; Altmüller J; Arrigoni L; Hummel B; Klein C; Frese CK; Sawarkar R; Rada-Iglesias A; Vilchez D
    Hum Mol Genet; 2018 Dec; 27(23):4117-4134. PubMed ID: 30452683
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease.
    Wetzel R
    Acc Chem Res; 2020 Oct; 53(10):2347-2357. PubMed ID: 32975927
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Progerin-Induced Transcriptional Changes in Huntington's Disease Human Pluripotent Stem Cell-Derived Neurons.
    Cohen-Carmon D; Sorek M; Lerner V; Divya MS; Nissim-Rafinia M; Yarom Y; Meshorer E
    Mol Neurobiol; 2020 Mar; 57(3):1768-1777. PubMed ID: 31834602
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models.
    Geijtenbeek KW; Janzen J; Bury AE; Sanz-Sanz A; Hoebe RA; Bondulich MK; Bates GP; Reits EAJ; Schipper-Krom S
    PLoS One; 2022; 17(12):e0278130. PubMed ID: 36574405
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity.
    Ghosh B; Karmakar S; Prasad M; Mandal AK
    Mol Biol Cell; 2021 Aug; 32(17):1579-1593. PubMed ID: 34161122
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones.
    Luo H; Cao L; Liang X; Du A; Peng T; Li H
    Mol Neurobiol; 2018 Oct; 55(10):7652-7668. PubMed ID: 29430620
    [TBL] [Abstract][Full Text] [Related]  

  • 12. TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
    Hegde RN; Chiki A; Petricca L; Martufi P; Arbez N; Mouchiroud L; Auwerx J; Landles C; Bates GP; Singh-Bains MK; Dragunow M; Curtis MA; Faull RL; Ross CA; Caricasole A; Lashuel HA
    EMBO J; 2020 Sep; 39(17):e104671. PubMed ID: 32757223
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting the proteostasis network in Huntington's disease.
    Soares TR; Reis SD; Pinho BR; Duchen MR; Oliveira JMA
    Ageing Res Rev; 2019 Jan; 49():92-103. PubMed ID: 30502498
    [TBL] [Abstract][Full Text] [Related]  

  • 14. FOXOs modulate proteasome activity in human-induced pluripotent stem cells of Huntington's disease and their derived neural cells.
    Liu Y; Qiao F; Leiferman PC; Ross A; Schlenker EH; Wang H
    Hum Mol Genet; 2017 Nov; 26(22):4416-4428. PubMed ID: 28973411
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of p38 Mitogen-Activated Protein Kinase Ameliorates HAP40 Depletion-Induced Toxicity and Proteasomal Defect in Huntington's Disease Model.
    Huang ZN; Chen JM; Huang LC; Fang YH; Her LS
    Mol Neurobiol; 2021 Jun; 58(6):2704-2723. PubMed ID: 33492644
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
    Miller DC; Lisowski P; Genehr C; Wanker EE; Priller J; Prigione A; Diecke S
    Stem Cell Res; 2023 Apr; 68():103056. PubMed ID: 36863131
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington's Disease.
    Merino M; Sequedo MD; Sánchez-Sánchez AV; Clares MP; García-España E; Vázquez-Manrique RP; Mullor JL
    Int J Mol Sci; 2022 Aug; 23(16):. PubMed ID: 36012207
    [TBL] [Abstract][Full Text] [Related]  

  • 18. PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates.
    Yue HW; Hong JY; Zhang SX; Jiang LL; Hu HY
    Sci Rep; 2021 Apr; 11(1):7815. PubMed ID: 33837238
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.
    Melkani GC; Trujillo AS; Ramos R; Bodmer R; Bernstein SI; Ocorr K
    PLoS Genet; 2013; 9(12):e1004024. PubMed ID: 24367279
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
    Li X; Wang CE; Huang S; Xu X; Li XJ; Li H; Li S
    Hum Mol Genet; 2010 Jun; 19(12):2445-55. PubMed ID: 20354076
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.