BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 30049586)

  • 21. Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy.
    Nishiura Y; Matsumura A; Kobayashi N; Shimazaki A; Sakamoto S; Kitade N; Tonomura Y; Ino A; Okuno T
    Bioorg Med Chem Lett; 2018 Aug; 28(14):2498-2503. PubMed ID: 29903660
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Novel 4,5-dihydrospiro[benzo[c]azepine-1,1'-cyclohexan]-3(2H)-one derivatives as PARP-1 inhibitors: Design, synthesis and biological evaluation.
    Li S; Li XY; Zhang TJ; Zhu J; Liu KL; Wang DP; Meng FH
    Bioorg Chem; 2021 Jun; 111():104840. PubMed ID: 33780687
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors.
    Wang J; Wang X; Li H; Ji D; Li Y; Xu Y; Zhu Q
    Bioorg Med Chem Lett; 2016 Aug; 26(16):4127-32. PubMed ID: 27353531
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.
    Okazaki S; Noguchi-Yachide T; Sakai T; Ishikawa M; Makishima M; Hashimoto Y; Yamaguchi T
    Bioorg Med Chem; 2016 Nov; 24(21):5258-5269. PubMed ID: 27591006
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
    Clark RF; Zhang T; Xin Z; Liu G; Wang Y; Hansen TM; Wang X; Wang R; Zhang X; Frevert EU; Camp HS; Beutel BA; Sham HL; Gu YG
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6078-81. PubMed ID: 16973360
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Antifolate and antiproliferative activity of 6,8,10-triazaspiro[4.5]deca-6,8-dienes and 1,3,5-triazaspiro[5.5]undeca-1,3-dienes.
    Ma X; Chui WK
    Bioorg Med Chem; 2010 Jan; 18(2):737-43. PubMed ID: 20036565
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitors.
    Wu X; Yu Y; Huang T
    J Enzyme Inhib Med Chem; 2021 Dec; 36(1):1236-1247. PubMed ID: 34100310
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.
    Ji C; Wang S; Chen S; He S; Jiang Y; Miao Z; Li J; Sheng C
    Bioorg Med Chem; 2017 Oct; 25(20):5268-5277. PubMed ID: 28797774
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.
    Mizojiri R; Asano M; Tomita D; Banno H; Nii N; Sasaki M; Sumi H; Satoh Y; Yamamoto Y; Moriya T; Satomi Y; Maezaki H
    J Med Chem; 2018 Feb; 61(3):1098-1117. PubMed ID: 29232514
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors.
    Itoh Y; Suzuki M
    Bioorg Med Chem Lett; 2018 Sep; 28(16):2723-2727. PubMed ID: 29548576
    [TBL] [Abstract][Full Text] [Related]  

  • 31. WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice.
    Gao YS; Qian MY; Wei QQ; Duan XB; Wang SL; Hu HY; Liu J; Pan CY; Zhang SQ; Qi LW; Zhou JP; Zhang HB; Wang LR
    Acta Pharmacol Sin; 2020 Mar; 41(3):336-347. PubMed ID: 31645659
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
    Bengtsson C; Blaho S; Saitton DB; Brickmann K; Broddefalk J; Davidsson O; Drmota T; Folmer R; Hallberg K; Hallén S; Hovland R; Isin E; Johannesson P; Kull B; Larsson LO; Löfgren L; Nilsson KE; Noeske T; Oakes N; Plowright AT; Schnecke V; Ståhlberg P; Sörme P; Wan H; Wellner E; Oster L
    Bioorg Med Chem; 2011 May; 19(10):3039-53. PubMed ID: 21515056
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis and Biological Evaluation of 1-(2-Aminophenyl)-3-arylurea Derivatives as Potential EphA2 and HDAC Dual Inhibitors.
    Zhu Y; Ran T; Chen X; Niu J; Zhao S; Lu T; Tang W
    Chem Pharm Bull (Tokyo); 2016; 64(8):1136-41. PubMed ID: 27477652
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
    Yamashita T; Kamata M; Endo S; Yamamoto M; Kakegawa K; Watanabe H; Miwa K; Yamano T; Funata M; Sakamoto J; Tani A; Mol CD; Zou H; Dougan DR; Sang B; Snell G; Fukatsu K
    Bioorg Med Chem Lett; 2011 Nov; 21(21):6314-8. PubMed ID: 21944854
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.
    Yao RS; Lu XQ; Guan QX; Zheng L; Lu X; Ruan BF
    Eur J Med Chem; 2013 Apr; 62():222-31. PubMed ID: 23353741
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
    Shinde P; Srivastava SK; Odedara R; Tuli D; Munshi S; Patel J; Zambad SP; Sonawane R; Gupta RC; Chauthaiwale V; Dutt C
    Bioorg Med Chem Lett; 2009 Feb; 19(3):949-53. PubMed ID: 19097787
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors.
    Abdullaziz MA; Abdel-Mohsen HT; El Kerdawy AM; Ragab FAF; Ali MM; Abu-Bakr SM; Girgis AS; El Diwani HI
    Eur J Med Chem; 2017 Aug; 136():315-329. PubMed ID: 28505536
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity.
    Freiberg C; Brunner NA; Schiffer G; Lampe T; Pohlmann J; Brands M; Raabe M; Häbich D; Ziegelbauer K
    J Biol Chem; 2004 Jun; 279(25):26066-73. PubMed ID: 15066985
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors.
    Jing T; Miao X; Jiang F; Guo M; Xing L; Zhang J; Zuo D; Lei H; Zhai X
    Bioorg Med Chem; 2018 May; 26(8):1784-1796. PubMed ID: 29496411
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Design, synthesis and biological evaluation of 2-phenylquinoline-4-carboxamide derivatives as a new class of tubulin polymerization inhibitors.
    Zhu L; Luo K; Li K; Jin Y; Lin J
    Bioorg Med Chem; 2017 Nov; 25(21):5939-5951. PubMed ID: 28988750
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.