BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 30052325)

  • 21. Electrocardiographic Characterization of Ramucirumab on the Corrected QT Interval in a Phase II Study of Patients With Advanced Solid Tumors.
    Olszanski AJ; Smith DC; Camacho LH; Thompson J; Ramalingam SS; Harvey RD; Campos L; Ferry D; Tang S; Gao L; Safran H
    Oncologist; 2016 Apr; 21(4):402-3. PubMed ID: 26984445
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin.
    Holzgrefe HH; Cavero I; Buchanan LV; Gill MW; Durham SK
    J Pharmacol Toxicol Methods; 2007; 55(3):227-37. PubMed ID: 17097307
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Sensitivity of common marmosets to detect drug-induced QT interval prolongation: moxifloxacin case study.
    Komatsu R; Honda M; Holzgrefe HH; Kubo J; Yamada Y; Isobe T; Kimura K; Itoh T; Tamaoki N; Tabo M
    J Pharmacol Toxicol Methods; 2010; 61(3):271-6. PubMed ID: 20097298
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Is a thorough QTc study necessary? The role of modeling and simulation in evaluating the QTc prolongation potential of drugs.
    Rohatagi S; Carrothers TJ; Kuwabara-Wagg J; Khariton T
    J Clin Pharmacol; 2009 Nov; 49(11):1284-96. PubMed ID: 19734373
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam.
    Das S; Armstrong J; Mathews D; Li J; Edeki T
    J Clin Pharmacol; 2014 Mar; 54(3):331-40. PubMed ID: 24150927
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Problems of heart rate correction in assessment of drug-induced QT interval prolongation.
    Malik M
    J Cardiovasc Electrophysiol; 2001 Apr; 12(4):411-20. PubMed ID: 11332559
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Four-Way Crossover Phase 1 Thorough QT Study to Assess Cardiac Safety of Domperidone and Consideration for Design and Conduct of QT/QTc Study in China.
    Wang F; Nie J; Yang L; Yang Z; Xu L; Wang L; Liao H; Li M; Wang P; Li G; Li H
    Clin Pharmacol Drug Dev; 2022 Jun; 11(6):734-743. PubMed ID: 35157791
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Importance of QT/RR hysteresis correction in studies of drug-induced QTc interval changes.
    Malik M; Garnett C; Hnatkova K; Johannesen L; Vicente J; Stockbridge N
    J Pharmacokinet Pharmacodyn; 2018 Jun; 45(3):491-503. PubMed ID: 29651591
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Vigabatrin Lacks Proarrhythmic Potential: Results from a Thorough QT/QTc Study in Healthy Volunteers.
    Tolbert D; Reid S; Harris S; Bekersky I
    Clin Ther; 2017 Aug; 39(8):1639-1648. PubMed ID: 28668627
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine.
    Patel N; Wisniowska B; Polak S
    AAPS J; 2018 Jul; 20(5):83. PubMed ID: 29995258
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Loxapine delivered as a thermally generated aerosol does not prolong QTc in a thorough QT/QTc study in healthy subjects.
    Spyker DA; Voloshko P; Heyman ER; Cassella JV
    J Clin Pharmacol; 2014 Jun; 54(6):665-74. PubMed ID: 24375070
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Phase 1 Study to Evaluate the Effect of the Investigational Anticancer Agent Sapanisertib on the QTc Interval in Patients With Advanced Solid Tumors.
    Patel C; Goel S; Patel MR; Rangachari L; Wilbur JD; Shou Y; Venkatakrishnan K; Lockhart AC
    Clin Pharmacol Drug Dev; 2020 Oct; 9(7):876-888. PubMed ID: 32488989
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Assessment of Azeliragon QTc Liability Through Integrated, Model-Based Concentration QTc Analysis.
    Burstein AH; Brantley SJ; Dunn I; Altstiel LD; Schmith V
    Clin Pharmacol Drug Dev; 2019 May; 8(4):426-435. PubMed ID: 30934161
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Effect of pomaglumetad methionil on the QT interval in subjects with schizophrenia.
    Zhang W; Mitchell MI; Knadler MP; Long A; Witcher J; Walling D; Annes W; Ayan-Oshodi M
    Int J Clin Pharmacol Ther; 2015 Jun; 53(6):462-70. PubMed ID: 25881753
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A thorough QT/QTc study of the effect of fasiglifam, a GPR40 agonist, on cardiac repolarization in healthy adults.
    Lee RD; Nudurupati S; Marcinak J; Viswanathan P
    Clin Pharmacol Drug Dev; 2015; 4(3):175-83. PubMed ID: 27140797
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization.
    Kleiman RB; Darpo B; Thorn M; Stoehr T; Schippers F
    Br J Clin Pharmacol; 2020 Aug; 86(8):1600-1609. PubMed ID: 32144789
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Daily dosing of vismodegib to steady state does not prolong the QTc interval in healthy volunteers.
    Graham RA; Chang I; Jin JY; Wang B; Dufek MB; Ayache JA; Ezzet F; Zerivitz K; Low JA; Dresser MJ
    J Cardiovasc Pharmacol; 2013 Jan; 61(1):83-9. PubMed ID: 23107871
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The imprecision in heart rate correction may lead to artificial observations of drug induced QT interval changes.
    Malik M
    Pacing Clin Electrophysiol; 2002 Feb; 25(2):209-16. PubMed ID: 11915990
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Cardiac repolarization with Gabapentin enacarbil in a randomized, double-blind, placebo- and active-controlled, crossover thorough QT/QTc study in healthy adults.
    Davy M; Upward J; Arumugham T; Twomey C; Chen C; Stier B
    Clin Ther; 2013 Dec; 35(12):1964-74. PubMed ID: 24290737
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Effects of Therapeutic and Supratherapeutic Doses of Siponimod (BAF312) on Cardiac Repolarization in Healthy Subjects.
    Shakeri-Nejad K; Aslanis V; Veldandi UK; Mooney L; Pezous N; Brendani B; Juan A; Allison M; Perry R; Legangneux E
    Clin Ther; 2015 Nov; 37(11):2489-2505.e2. PubMed ID: 26519230
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.