BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 30060061)

  • 1. First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer.
    Massard C; Azaro A; Soria JC; Lassen U; Le Tourneau C; Sarker D; Smith C; Ohnmacht U; Oakley G; Patel BKR; Yuen ESM; Benhadji KA; Rodon J
    Ann Oncol; 2018 Sep; 29(9):1911-1917. PubMed ID: 30060061
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phase 1 study of 2 high dose intensity schedules of the pan-Notch inhibitor crenigacestat (LY3039478) in combination with prednisone in patients with advanced or metastatic cancer.
    Azaro A; Baldini C; Rodon J; Soria JC; Yuen E; Lithio A; Oakley G; Benhadji KA; Massard C
    Invest New Drugs; 2021 Feb; 39(1):193-201. PubMed ID: 32915419
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A phase 1 study of crenigacestat (LY3039478), the Notch inhibitor, in Japanese patients with advanced solid tumors.
    Doi T; Tajimi M; Mori J; Asou H; Inoue K; Benhadji KA; Naito Y
    Invest New Drugs; 2021 Apr; 39(2):469-476. PubMed ID: 32939607
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A phase 1b study of the Notch inhibitor crenigacestat (LY3039478) in combination with other anticancer target agents (taladegib, LY3023414, or abemaciclib) in patients with advanced or metastatic solid tumors.
    Azaro A; Massard C; Tap WD; Cassier PA; Merchan J; Italiano A; Anderson B; Yuen E; Yu D; Oakley G; Benhadji KA; Pant S
    Invest New Drugs; 2021 Aug; 39(4):1089-1098. PubMed ID: 33686452
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer.
    Pant S; Jones SF; Kurkjian CD; Infante JR; Moore KN; Burris HA; McMeekin DS; Benhadji KA; Patel BKR; Frenzel MJ; Kursar JD; Zamek-Gliszczynski MJ; Yuen ESM; Chan EM; Bendell JC
    Eur J Cancer; 2016 Mar; 56():1-9. PubMed ID: 26798966
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A phase 1b study of crenigacestat (LY3039478) in combination with gemcitabine and cisplatin or gemcitabine and carboplatin in patients with advanced or metastatic solid tumors.
    Massard C; Cassier PA; Azaro A; Anderson B; Yuen E; Yu D; Oakley G; Benhadji KA; Pant S
    Cancer Chemother Pharmacol; 2022 Oct; 90(4):335-344. PubMed ID: 36030462
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma.
    Even C; Lassen U; Merchan J; Le Tourneau C; Soria JC; Ferte C; Ricci F; Diener JT; Yuen E; Smith C; Oakley GJ; Benhadji KA; Massard C
    Invest New Drugs; 2020 Apr; 38(2):402-409. PubMed ID: 30953269
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).
    Richter S; Bedard PL; Chen EX; Clarke BA; Tran B; Hotte SJ; Stathis A; Hirte HW; Razak AR; Reedijk M; Chen Z; Cohen B; Zhang WJ; Wang L; Ivy SP; Moore MJ; Oza AM; Siu LL; McWhirter E
    Invest New Drugs; 2014 Apr; 32(2):243-9. PubMed ID: 23645447
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Notch pathway inhibition with LY3039478 in soft tissue sarcoma and gastrointestinal stromal tumours.
    Mir O; Azaro A; Merchan J; Chugh R; Trent J; Rodon J; Ohnmacht U; Diener JT; Smith C; Yuen E; Oakley GJ; Le Cesne A; Soria JC; Benhadji KA; Massard C
    Eur J Cancer; 2018 Nov; 103():88-97. PubMed ID: 30218977
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phase 1 study to evaluate Crenigacestat (LY3039478) in combination with dexamethasone in patients with T-cell acute lymphoblastic leukemia and lymphoma.
    Borthakur G; Martinelli G; Raffoux E; Chevallier P; Chromik J; Lithio A; Smith CL; Yuen E; Oakley GJ; Benhadji KA; DeAngelo DJ
    Cancer; 2021 Feb; 127(3):372-380. PubMed ID: 33107983
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.
    Tolcher AW; Messersmith WA; Mikulski SM; Papadopoulos KP; Kwak EL; Gibbon DG; Patnaik A; Falchook GS; Dasari A; Shapiro GI; Boylan JF; Xu ZX; Wang K; Koehler A; Song J; Middleton SA; Deutsch J; Demario M; Kurzrock R; Wheler JJ
    J Clin Oncol; 2012 Jul; 30(19):2348-53. PubMed ID: 22529266
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors.
    Diaz-Padilla I; Hirte H; Oza AM; Clarke BA; Cohen B; Reedjik M; Zhang T; Kamel-Reid S; Ivy SP; Hotte SJ; Razak AA; Chen EX; Brana I; Wizemann M; Wang L; Siu LL; Bedard PL
    Invest New Drugs; 2013 Oct; 31(5):1182-91. PubMed ID: 23860641
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.
    Krop I; Demuth T; Guthrie T; Wen PY; Mason WP; Chinnaiyan P; Butowski N; Groves MD; Kesari S; Freedman SJ; Blackman S; Watters J; Loboda A; Podtelezhnikov A; Lunceford J; Chen C; Giannotti M; Hing J; Beckman R; Lorusso P
    J Clin Oncol; 2012 Jul; 30(19):2307-13. PubMed ID: 22547604
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A multicenter phase 1 study of γ -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors.
    LoConte NK; Razak AR; Ivy P; Tevaarwerk A; Leverence R; Kolesar J; Siu L; Lubner SJ; Mulkerin DL; Schelman WR; Deming DA; Holen KD; Carmichael L; Eickhoff J; Liu G
    Invest New Drugs; 2015 Feb; 33(1):169-76. PubMed ID: 25318436
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Notch Inhibitor Shows Modest Efficacy.
    Cancer Discov; 2017 Feb; 7(2):OF3. PubMed ID: 27974417
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
    Wei P; Walls M; Qiu M; Ding R; Denlinger RH; Wong A; Tsaparikos K; Jani JP; Hosea N; Sands M; Randolph S; Smeal T
    Mol Cancer Ther; 2010 Jun; 9(6):1618-28. PubMed ID: 20530712
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.
    Messersmith WA; Shapiro GI; Cleary JM; Jimeno A; Dasari A; Huang B; Shaik MN; Cesari R; Zheng X; Reynolds JM; English PA; McLachlan KR; Kern KA; LoRusso PM
    Clin Cancer Res; 2015 Jan; 21(1):60-7. PubMed ID: 25231399
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933.
    Lee SM; Moon J; Redman BG; Chidiac T; Flaherty LE; Zha Y; Othus M; Ribas A; Sondak VK; Gajewski TF; Margolin KA
    Cancer; 2015 Feb; 121(3):432-440. PubMed ID: 25250858
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours.
    Aung KL; El-Khoueiry AB; Gelmon K; Tran B; Bajaj G; He B; Chen T; Zhu L; Poojary S; Basak S; Qi Z; Spreafico A; Fischer BS; Desai J
    Invest New Drugs; 2018 Dec; 36(6):1026-1036. PubMed ID: 29637471
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial.
    Heery CR; O'Sullivan-Coyne G; Madan RA; Cordes L; Rajan A; Rauckhorst M; Lamping E; Oyelakin I; Marté JL; Lepone LM; Donahue RN; Grenga I; Cuillerot JM; Neuteboom B; Heydebreck AV; Chin K; Schlom J; Gulley JL
    Lancet Oncol; 2017 May; 18(5):587-598. PubMed ID: 28373007
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.