BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

324 related articles for article (PubMed ID: 30061680)

  • 21. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
    Kim SH; Choi JH; Wang P; Go CD; Hesketh GG; Gingras AC; Jafarnejad SM; Sonenberg N
    Mol Cell; 2021 Jan; 81(2):398-407.e4. PubMed ID: 33340489
    [TBL] [Abstract][Full Text] [Related]  

  • 22. MORG1 limits mTORC1 signaling by inhibiting Rag GTPases.
    Abudu YP; Kournoutis A; Brenne HB; Lamark T; Johansen T
    Mol Cell; 2024 Feb; 84(3):552-569.e11. PubMed ID: 38103557
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.
    Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
    PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
    [TBL] [Abstract][Full Text] [Related]  

  • 24. RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121.
    Sekiguchi T; Furuno N; Ishii T; Hirose E; Sekiguchi F; Wang Y; Kobayashi H
    Genes Cells; 2019 Feb; 24(2):151-161. PubMed ID: 30570184
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization.
    Kwon O; Kwak D; Ha SH; Jeon H; Park M; Chang Y; Suh PG; Ryu SH
    Cell Signal; 2017 Apr; 32():24-35. PubMed ID: 28089905
    [TBL] [Abstract][Full Text] [Related]  

  • 26. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
    Bar-Peled L; Chantranupong L; Cherniack AD; Chen WW; Ottina KA; Grabiner BC; Spear ED; Carter SL; Meyerson M; Sabatini DM
    Science; 2013 May; 340(6136):1100-6. PubMed ID: 23723238
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
    Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
    Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
    [TBL] [Abstract][Full Text] [Related]  

  • 28. An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids.
    Egri SB; Shen K
    J Biol Chem; 2021 Jul; 297(1):100861. PubMed ID: 34116056
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
    Bar-Peled L; Schweitzer LD; Zoncu R; Sabatini DM
    Cell; 2012 Sep; 150(6):1196-208. PubMed ID: 22980980
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells.
    Doxsey DD; Tettoni SD; Egri SB; Shen K
    J Biol Chem; 2023 Jul; 299(7):104880. PubMed ID: 37269949
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.
    Chia KH; Fukuda T; Sofyantoro F; Matsuda T; Amai T; Shiozaki K
    Elife; 2017 Dec; 6():. PubMed ID: 29199950
    [TBL] [Abstract][Full Text] [Related]  

  • 32. A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability.
    Pu J; Keren-Kaplan T; Bonifacino JS
    J Cell Biol; 2017 Dec; 216(12):4183-4197. PubMed ID: 28993468
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
    Anandapadamanaban M; Masson GR; Perisic O; Berndt A; Kaufman J; Johnson CM; Santhanam B; Rogala KB; Sabatini DM; Williams RL
    Science; 2019 Oct; 366(6462):203-210. PubMed ID: 31601764
    [TBL] [Abstract][Full Text] [Related]  

  • 34. The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by
    Zheng Z; Deng W; Bai Y; Miao R; Mei S; Zhang Z; Pan Y; Wang Y; Min R; Deng F; Wu Z; Li W; Chen P; Ma T; Lou X; Lieberman J; Liu X
    Science; 2021 Jun; 372(6549):. PubMed ID: 35058659
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Regulation of mTORC1 by the Rag GTPases.
    Lama-Sherpa TD; Jeong MH; Jewell JL
    Biochem Soc Trans; 2023 Apr; 51(2):655-664. PubMed ID: 36929165
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
    Shen K; Choe A; Sabatini DM
    Mol Cell; 2017 Nov; 68(3):552-565.e8. PubMed ID: 29056322
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
    de Araujo MEG; Naschberger A; Fürnrohr BG; Stasyk T; Dunzendorfer-Matt T; Lechner S; Welti S; Kremser L; Shivalingaiah G; Offterdinger M; Lindner HH; Huber LA; Scheffzek K
    Science; 2017 Oct; 358(6361):377-381. PubMed ID: 28935770
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.
    Hesketh GG; Papazotos F; Pawling J; Rajendran D; Knight JDR; Martinez S; Taipale M; Schramek D; Dennis JW; Gingras AC
    Science; 2020 Oct; 370(6514):351-356. PubMed ID: 33060361
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
    Shin HR; Citron YR; Wang L; Tribouillard L; Goul CS; Stipp R; Sugasawa Y; Jain A; Samson N; Lim CY; Davis OB; Castaneda-Carpio D; Qian M; Nomura DK; Perera RM; Park E; Covey DF; Laplante M; Evers AS; Zoncu R
    Science; 2022 Sep; 377(6612):1290-1298. PubMed ID: 36007018
    [TBL] [Abstract][Full Text] [Related]  

  • 40. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.
    Gan L; Seki A; Shen K; Iyer H; Han K; Hayer A; Wollman R; Ge X; Lin JR; Dey G; Talbot WS; Meyer T
    Nat Cell Biol; 2019 May; 21(5):614-626. PubMed ID: 31036939
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 17.