168 related articles for article (PubMed ID: 30087384)
1. Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases.
Ordan M; Pallara C; Maik-Rachline G; Hanoch T; Gervasio FL; Glaser F; Fernandez-Recio J; Seger R
Sci Rep; 2018 Aug; 8(1):11830. PubMed ID: 30087384
[TBL] [Abstract][Full Text] [Related]
2. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options.
Senawong T; Phuchareon J; Ohara O; McCormick F; Rauen KA; Tetsu O
Hum Mol Genet; 2008 Feb; 17(3):419-30. PubMed ID: 17981815
[TBL] [Abstract][Full Text] [Related]
3. BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Emery CM; Monaco KA; Wang P; Balak M; Freeman A; Meltzer J; Delach SM; Rakiec D; Ruddy DA; Korn JM; Haling J; Acker MG; Caponigro G
Mol Cancer Res; 2017 Oct; 15(10):1431-1444. PubMed ID: 28655712
[TBL] [Abstract][Full Text] [Related]
4. MEK1/2 dual-specificity protein kinases: structure and regulation.
Roskoski R
Biochem Biophys Res Commun; 2012 Jan; 417(1):5-10. PubMed ID: 22177953
[TBL] [Abstract][Full Text] [Related]
5. Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect.
Aoidi R; Maltais A; Charron J
Sci Signal; 2016 Jan; 9(412):ra9. PubMed ID: 26814233
[TBL] [Abstract][Full Text] [Related]
6. Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis.
Procaccia S; Ordan M; Cohen I; Bendetz-Nezer S; Seger R
Sci Rep; 2017 Feb; 7():43078. PubMed ID: 28225038
[TBL] [Abstract][Full Text] [Related]
7. Molecular mechanisms underlying cellular effects of human MEK1 mutations.
Marmion RA; Yang L; Goyal Y; Jindal GA; Wetzel JL; Singh M; Schüpbach T; Shvartsman SY
Mol Biol Cell; 2021 Apr; 32(9):974-983. PubMed ID: 33476180
[TBL] [Abstract][Full Text] [Related]
8. MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K.
Guégan JP; Ezan F; Gailhouste L; Langouët S; Baffet G
J Cell Physiol; 2014 Jul; 229(7):903-15. PubMed ID: 24501087
[TBL] [Abstract][Full Text] [Related]
9. ERK1/2 can feedback-regulate cellular MEK1/2 levels.
Hong SK; Wu PK; Karkhanis M; Park JI
Cell Signal; 2015 Oct; 27(10):1939-48. PubMed ID: 26163823
[TBL] [Abstract][Full Text] [Related]
10. Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma.
Burgermeister E; Chuderland D; Hanoch T; Meyer M; Liscovitch M; Seger R
Mol Cell Biol; 2007 Feb; 27(3):803-17. PubMed ID: 17101779
[TBL] [Abstract][Full Text] [Related]
11. Crucial requirement of ERK/MAPK signaling in respiratory tract development.
Boucherat O; Nadeau V; Bérubé-Simard FA; Charron J; Jeannotte L
Development; 2014 Aug; 141(16):3197-211. PubMed ID: 25100655
[TBL] [Abstract][Full Text] [Related]
12. Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2.
Piao C; Jin M; Kim HB; Lee SM; Amatya PN; Hyun JW; Chang IY; You HJ
Oncogene; 2009 May; 28(21):2173-84. PubMed ID: 19398949
[TBL] [Abstract][Full Text] [Related]
13. p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-alpha induced endothelial apoptosis.
Grethe S; Pörn-Ares MI
Cell Signal; 2006 Apr; 18(4):531-40. PubMed ID: 15972258
[TBL] [Abstract][Full Text] [Related]
14. Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.
Grewal S; Molina DM; Bardwell L
Cell Signal; 2006 Jan; 18(1):123-34. PubMed ID: 15979847
[TBL] [Abstract][Full Text] [Related]
15. RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo.
Gailhouste L; Ezan F; Bessard A; Frémin C; Rageul J; Langouët S; Baffet G
Int J Cancer; 2010 Mar; 126(6):1367-77. PubMed ID: 19816936
[TBL] [Abstract][Full Text] [Related]
16. MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly.
Tsai J; Qiu W; Kohen-Avramoglu R; Adeli K
Arterioscler Thromb Vasc Biol; 2007 Jan; 27(1):211-8. PubMed ID: 17038630
[TBL] [Abstract][Full Text] [Related]
17. Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.
Scholl FA; Dumesic PA; Barragan DI; Harada K; Bissonauth V; Charron J; Khavari PA
Dev Cell; 2007 Apr; 12(4):615-29. PubMed ID: 17419998
[TBL] [Abstract][Full Text] [Related]
18. Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: role of ERK kinase 1 (MEK1).
Dwivedi Y; Rizavi HS; Zhang H; Roberts RC; Conley RR; Pandey GN
Int J Neuropsychopharmacol; 2009 Nov; 12(10):1337-54. PubMed ID: 19835659
[TBL] [Abstract][Full Text] [Related]
19. Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.
Lue H; Kapurniotu A; Fingerle-Rowson G; Roger T; Leng L; Thiele M; Calandra T; Bucala R; Bernhagen J
Cell Signal; 2006 May; 18(5):688-703. PubMed ID: 16122907
[TBL] [Abstract][Full Text] [Related]
20. Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.
Wang H; Daouti S; Li WH; Wen Y; Rizzo C; Higgins B; Packman K; Rosen N; Boylan JF; Heimbrook D; Niu H
Cancer Res; 2011 Aug; 71(16):5535-45. PubMed ID: 21705440
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
