BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 30089852)

  • 1. PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes.
    Wang Q; Yu M; Ma Y; Zhang X; Zhang H; Li S; Lan R; Lu F
    Lab Invest; 2018 Dec; 98(12):1627-1641. PubMed ID: 30089852
    [TBL] [Abstract][Full Text] [Related]  

  • 2. LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.
    Zhang C; Hoang N; Leng F; Saxena L; Lee L; Alejo S; Qi D; Khal A; Sun H; Lu F; Zhang H
    J Biol Chem; 2018 Mar; 293(10):3663-3674. PubMed ID: 29358331
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
    Alicea-Velázquez NL; Shinsky SA; Loh DM; Lee JH; Skalnik DG; Cosgrove MS
    J Biol Chem; 2016 Oct; 291(43):22357-22372. PubMed ID: 27563068
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.
    Estève PO; Terragni J; Deepti K; Chin HG; Dai N; Espejo A; Corrêa IR; Bedford MT; Pradhan S
    J Biol Chem; 2014 Mar; 289(12):8277-87. PubMed ID: 24492612
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4
    Zhang C; Leng F; Saxena L; Hoang N; Yu J; Alejo S; Lee L; Qi D; Lu F; Sun H; Zhang H
    J Biol Chem; 2019 Jan; 294(2):476-489. PubMed ID: 30442713
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
    Dharmarajan V; Lee JH; Patel A; Skalnik DG; Cosgrove MS
    J Biol Chem; 2012 Aug; 287(33):27275-89. PubMed ID: 22665483
    [TBL] [Abstract][Full Text] [Related]  

  • 7. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Dharmarajan V; Vought VE; Cosgrove MS
    J Biol Chem; 2009 Sep; 284(36):24242-56. PubMed ID: 19556245
    [TBL] [Abstract][Full Text] [Related]  

  • 8. An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
    Cao F; Chen Y; Cierpicki T; Liu Y; Basrur V; Lei M; Dou Y
    PLoS One; 2010 Nov; 5(11):e14102. PubMed ID: 21124902
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.
    Weirich S; Kudithipudi S; Jeltsch A
    Mol Oncol; 2017 Apr; 11(4):373-387. PubMed ID: 28182322
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16
    Shimoda H; Doi S; Nakashima A; Sasaki K; Doi T; Masaki T
    Kidney Int; 2019 Nov; 96(5):1162-1175. PubMed ID: 31570196
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein- Protein Interaction.
    Ye X; Chen G; Jin J; Zhang B; Wang Y; Cai Z; Ye F
    Curr Med Chem; 2020; 27(33):5530-5542. PubMed ID: 31132972
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Vought VE; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2011 Feb; 286(5):3359-69. PubMed ID: 21106533
    [TBL] [Abstract][Full Text] [Related]  

  • 13. MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.
    Wu M; Shu HB
    Chin J Cancer; 2011 Apr; 30(4):240-6. PubMed ID: 21439245
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.
    Chen WL; Li DD; Chen X; Wang YZ; Xu JJ; Jiang ZY; You QD; Guo XK
    Eur J Med Chem; 2020 Feb; 188():112027. PubMed ID: 31923859
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
    Patel A; Vought VE; Swatkoski S; Viggiano S; Howard B; Dharmarajan V; Monteith KE; Kupakuwana G; Namitz KE; Shinsky SA; Cotter RJ; Cosgrove MS
    J Biol Chem; 2014 Jan; 289(2):868-84. PubMed ID: 24235145
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia by attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription.
    Lin TB; Lai CY; Hsieh MC; Ho YC; Wang HH; Yang PS; Cheng JK; Chen GD; Ng SC; Peng HY
    Pain; 2020 Sep; 161(9):1995-2009. PubMed ID: 32345914
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
    Patel A; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2008 Nov; 283(47):32158-61. PubMed ID: 18829459
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation of MLL1 H3K4 methyltransferase activity by its core components.
    Dou Y; Milne TA; Ruthenburg AJ; Lee S; Lee JW; Verdine GL; Allis CD; Roeder RG
    Nat Struct Mol Biol; 2006 Aug; 13(8):713-9. PubMed ID: 16878130
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity.
    Chen W; Chen X; Li D; Wang X; Long G; Jiang Z; You Q; Guo X
    Eur J Med Chem; 2021 Nov; 223():113677. PubMed ID: 34225179
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis of nucleosome recognition and modification by MLL methyltransferases.
    Xue H; Yao T; Cao M; Zhu G; Li Y; Yuan G; Chen Y; Lei M; Huang J
    Nature; 2019 Sep; 573(7774):445-449. PubMed ID: 31485071
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.