252 related articles for article (PubMed ID: 30097175)
1. Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles.
Liao TJ; Jang H; Fushman D; Nussinov R
Biophys J; 2018 Aug; 115(4):629-641. PubMed ID: 30097175
[TBL] [Abstract][Full Text] [Related]
2. Studying early structural changes in SOS1 mediated KRAS activation mechanism.
Bhadhadhara K; Jani V; Koulgi S; Sonavane U; Joshi R
Curr Res Struct Biol; 2024; 7():100115. PubMed ID: 38188543
[TBL] [Abstract][Full Text] [Related]
3. A Ras-induced conformational switch in the Ras activator Son of sevenless.
Freedman TS; Sondermann H; Friedland GD; Kortemme T; Bar-Sagi D; Marqusee S; Kuriyan J
Proc Natl Acad Sci U S A; 2006 Nov; 103(45):16692-7. PubMed ID: 17075039
[TBL] [Abstract][Full Text] [Related]
4. Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.
Vo U; Vajpai N; Flavell L; Bobby R; Breeze AL; Embrey KJ; Golovanov AP
J Biol Chem; 2016 Jan; 291(4):1703-1718. PubMed ID: 26565026
[TBL] [Abstract][Full Text] [Related]
5. Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
Sarkar D; Olejniczak ET; Phan J; Coker JA; Sai J; Arnold A; Beesetty Y; Waterson AG; Fesik SW
J Med Chem; 2020 Aug; 63(15):8325-8337. PubMed ID: 32673492
[TBL] [Abstract][Full Text] [Related]
6. Membrane-dependent signal integration by the Ras activator Son of sevenless.
Gureasko J; Galush WJ; Boykevisch S; Sondermann H; Bar-Sagi D; Groves JT; Kuriyan J
Nat Struct Mol Biol; 2008 May; 15(5):452-61. PubMed ID: 18454158
[TBL] [Abstract][Full Text] [Related]
7. Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect.
He X; Du K; Wang Y; Fan J; Li M; Ni D; Lu S; Bian X; Liu Y
Front Mol Biosci; 2022; 9():860962. PubMed ID: 35463958
[TBL] [Abstract][Full Text] [Related]
8. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Burns MC; Howes JE; Sun Q; Little AJ; Camper DV; Abbott JR; Phan J; Lee T; Waterson AG; Rossanese OW; Fesik SW
Anal Biochem; 2018 May; 548():44-52. PubMed ID: 29444450
[TBL] [Abstract][Full Text] [Related]
9. Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution.
Vo U; Vajpai N; Embrey KJ; Golovanov AP
Sci Rep; 2016 Jul; 6():29706. PubMed ID: 27412770
[TBL] [Abstract][Full Text] [Related]
10. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC; Sautier B; Schroeder J; Moosmayer D; Hilpmann A; Stegmann CM; Werbeck ND; Briem H; Boemer U; Weiske J; Badock V; Mastouri J; Petersen K; Siemeister G; Kahmann JD; Wegener D; Böhnke N; Eis K; Graham K; Wortmann L; von Nussbaum F; Bader B
Proc Natl Acad Sci U S A; 2019 Feb; 116(7):2551-2560. PubMed ID: 30683722
[TBL] [Abstract][Full Text] [Related]
11. Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.
Quilliam LA; Huff SY; Rabun KM; Wei W; Park W; Broek D; Der CJ
Proc Natl Acad Sci U S A; 1994 Aug; 91(18):8512-6. PubMed ID: 8078913
[TBL] [Abstract][Full Text] [Related]
12. Prenylation of Ras facilitates hSOS1-promoted nucleotide exchange, upon Ras binding to the regulatory site.
Pechlivanis M; Ringel R; Popkirova B; Kuhlmann J
Biochemistry; 2007 May; 46(18):5341-8. PubMed ID: 17437339
[TBL] [Abstract][Full Text] [Related]
13. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Hodges TR; Abbott JR; Little AJ; Sarkar D; Salovich JM; Howes JE; Akan DT; Sai J; Arnold AL; Browning C; Burns MC; Sobolik T; Sun Q; Beesetty Y; Coker JA; Scharn D; Stadtmueller H; Rossanese OW; Phan J; Waterson AG; McConnell DB; Fesik SW
J Med Chem; 2018 Oct; 61(19):8875-8894. PubMed ID: 30205005
[TBL] [Abstract][Full Text] [Related]
14. Guanine nucleotide exchange factors: activators of Ras superfamily proteins.
Overbeck AF; Brtva TR; Cox AD; Graham SM; Huff SY; Khosravi-Far R; Quilliam LA; Solski PA; Der CJ
Mol Reprod Dev; 1995 Dec; 42(4):468-76. PubMed ID: 8607978
[TBL] [Abstract][Full Text] [Related]
15. PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b.
McLean MA; Stephen AG; Sligar SG
Biochemistry; 2019 Aug; 58(33):3537-3545. PubMed ID: 31339036
[TBL] [Abstract][Full Text] [Related]
16. Normal Mode Analysis of KRas4B Reveals Partner Specific Dynamics.
Eren M; Tuncbag N; Jang H; Nussinov R; Gursoy A; Keskin O
J Phys Chem B; 2021 May; 125(20):5210-5221. PubMed ID: 33978412
[TBL] [Abstract][Full Text] [Related]
17. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.
Roose JP; Mollenauer M; Ho M; Kurosaki T; Weiss A
Mol Cell Biol; 2007 Apr; 27(7):2732-45. PubMed ID: 17283063
[TBL] [Abstract][Full Text] [Related]
18. Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors.
Mosteller RD; Han J; Broek D
Mol Cell Biol; 1994 Feb; 14(2):1104-12. PubMed ID: 8289791
[TBL] [Abstract][Full Text] [Related]
19. Structural basis of the atypical activation mechanism of KRAS
Bera AK; Lu J; Wales TE; Gondi S; Gurbani D; Nelson A; Engen JR; Westover KD
J Biol Chem; 2019 Sep; 294(38):13964-13972. PubMed ID: 31341022
[TBL] [Abstract][Full Text] [Related]
20. Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm.
Lenzen C; Cool RH; Prinz H; Kuhlmann J; Wittinghofer A
Biochemistry; 1998 May; 37(20):7420-30. PubMed ID: 9585556
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]