BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

264 related articles for article (PubMed ID: 30104200)

  • 1. Rethinking Gamma-secretase Inhibitors for Treatment of Non-small-Cell Lung Cancer: Is Notch the Target?
    Pine SR
    Clin Cancer Res; 2018 Dec; 24(24):6136-6141. PubMed ID: 30104200
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.
    Konishi J; Kawaguchi KS; Vo H; Haruki N; Gonzalez A; Carbone DP; Dang TP
    Cancer Res; 2007 Sep; 67(17):8051-7. PubMed ID: 17804716
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
    Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W
    Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Notching up a new therapeutic strategy for non-small cell lung carcinoma (NSCLC).
    Maraver A; Serrano M
    Oncotarget; 2012 Sep; 3(9):917-8. PubMed ID: 23007024
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer.
    Sakakibara-Konishi J; Ikezawa Y; Oizumi S; Kikuchi J; Kikuchi E; Mizugaki H; Kinoshita I; Dosaka-Akita H; Nishimura M
    Int J Clin Oncol; 2017 Apr; 22(2):257-268. PubMed ID: 27816990
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.
    Luistro L; He W; Smith M; Packman K; Vilenchik M; Carvajal D; Roberts J; Cai J; Berkofsky-Fessler W; Hilton H; Linn M; Flohr A; Jakob-Røtne R; Jacobsen H; Glenn K; Heimbrook D; Boylan JF
    Cancer Res; 2009 Oct; 69(19):7672-80. PubMed ID: 19773430
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy.
    Liu J; Mao Z; Huang J; Xie S; Liu T; Mao Z
    Biochem Biophys Res Commun; 2014 Feb; 444(4):670-5. PubMed ID: 24502949
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.
    Saito N; Fu J; Zheng S; Yao J; Wang S; Liu DD; Yuan Y; Sulman EP; Lang FF; Colman H; Verhaak RG; Yung WK; Koul D
    Stem Cells; 2014 Jan; 32(1):301-12. PubMed ID: 24038660
    [TBL] [Abstract][Full Text] [Related]  

  • 9. γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer.
    Mizugaki H; Sakakibara-Konishi J; Ikezawa Y; Kikuchi J; Kikuchi E; Oizumi S; Dang TP; Nishimura M
    Br J Cancer; 2012 Jun; 106(12):1953-9. PubMed ID: 22596234
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
    Wei P; Walls M; Qiu M; Ding R; Denlinger RH; Wong A; Tsaparikos K; Jani JP; Hosea N; Sands M; Randolph S; Smeal T
    Mol Cancer Ther; 2010 Jun; 9(6):1618-28. PubMed ID: 20530712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Small molecules that inhibit Notch signaling.
    De Kloe GE; De Strooper B
    Methods Mol Biol; 2014; 1187():311-22. PubMed ID: 25053499
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Doubling down with inhibitors of Notch and Hedgehog signaling pathways.
    Weiss GJ
    J Thorac Oncol; 2012 Dec; 7(16 Suppl 5):S409-10. PubMed ID: 23160337
    [No Abstract]   [Full Text] [Related]  

  • 13. Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer.
    Feng Z; Xu W; Zhang C; Liu M; Wen H
    Oncotarget; 2017 Jan; 8(5):8215-8225. PubMed ID: 28030808
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NOTCH signaling as a novel cancer therapeutic target.
    Miele L; Miao H; Nickoloff BJ
    Curr Cancer Drug Targets; 2006 Jun; 6(4):313-23. PubMed ID: 16848722
    [TBL] [Abstract][Full Text] [Related]  

  • 15. [Inhibitors for Notch and gamma-secretase. Biology of T-cell leukemia].
    Yahagi Y; Usui N
    Gan To Kagaku Ryoho; 2009 May; 36(5):744-8. PubMed ID: 19496283
    [No Abstract]   [Full Text] [Related]  

  • 16. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.
    Groth C; Fortini ME
    Semin Cell Dev Biol; 2012 Jun; 23(4):465-72. PubMed ID: 22309842
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms and clinical prospects of Notch inhibitors in the therapy of hematological malignancies.
    Nefedova Y; Gabrilovich D
    Drug Resist Updat; 2008 Dec; 11(6):210-8. PubMed ID: 18951834
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.
    Groth C; Alvord WG; Quiñones OA; Fortini ME
    Mol Pharmacol; 2010 Apr; 77(4):567-74. PubMed ID: 20064975
    [TBL] [Abstract][Full Text] [Related]  

  • 19. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.
    Meng X; Matlawska-Wasowska K; Girodon F; Mazel T; Willman CL; Atlas S; Chen IM; Harvey RC; Hunger SP; Ness SA; Winter SS; Wilson BS
    Leukemia; 2011 Jul; 25(7):1135-46. PubMed ID: 21494254
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo.
    Osanyingbemi-Obidi J; Dobromilskaya I; Illei PB; Hann CL; Rudin CM
    Mol Cancer Res; 2011 Dec; 9(12):1746-54. PubMed ID: 21994468
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.