114 related articles for article (PubMed ID: 3011010)
1. Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5-ethyl-2'-deoxyuridine and 5-(2-chloroethyl)-2'-deoxyuridine.
Desgranges C; De Clercq E; Razaka G; Drouillet F; Belloc I; Bricaud H
Biochem Pharmacol; 1986 May; 35(10):1647-53. PubMed ID: 3011010
[TBL] [Abstract][Full Text] [Related]
2. Regeneration of the antiviral drug (E)-5-(2-bromovinyl)-2'-deoxyuridine in vivo.
Desgranges C; Razaka G; Drouillet F; Bricaud H; Herdewijn P; De Clercq E
Nucleic Acids Res; 1984 Feb; 12(4):2081-90. PubMed ID: 6701093
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
De Clercq E; Desgranges C; Herdewijn P; Sim IS; Jones AS; McLean MJ; Walker RT
J Med Chem; 1986 Feb; 29(2):213-7. PubMed ID: 3005566
[TBL] [Abstract][Full Text] [Related]
4. Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets.
Desgranges C; Razaka G; Rabaud M; Bricaud H; Balzarini J; De Clercq E
Biochem Pharmacol; 1983 Dec; 32(23):3583-90. PubMed ID: 6651877
[TBL] [Abstract][Full Text] [Related]
5. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.
De Clercq E; Descamps J; De Somer P; Barr PJ; Jones AS; Walker RT
Proc Natl Acad Sci U S A; 1979 Jun; 76(6):2947-51. PubMed ID: 223163
[TBL] [Abstract][Full Text] [Related]
6. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Shimizu K; Seno T
Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
Jones AS; Rahim SG; Walker RT; De Clercq E
J Med Chem; 1981 Jun; 24(6):759-60. PubMed ID: 6265638
[TBL] [Abstract][Full Text] [Related]
8. The synthesis and properties of some 5-substituted uracil derivatives.
Walker RT; Jones AS; Rahim SG; Serafinowski P; De Clercq E
Nucleic Acids Symp Ser; 1981; (9):21-4. PubMed ID: 7301597
[TBL] [Abstract][Full Text] [Related]
9. Comparative metabolism of E-5-(2-bromovinyl)-2'-deoxyuridine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in herpes simplex virus-infected cells.
Ayisi NK; Wall RA; Wanklin RJ; Machida H; De Clercq E; Sacks SL
Mol Pharmacol; 1987 Apr; 31(4):422-9. PubMed ID: 3472064
[TBL] [Abstract][Full Text] [Related]
10. Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Desgranges C; Razaka G; De Clercq E; Herdewijn P; Balzarini J; Drouillet F; Bricaud H
Cancer Res; 1986 Mar; 46(3):1094-101. PubMed ID: 3943086
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Herdewijn P; De Clercq E; Balzarini J; Vanderhaeghe H
J Med Chem; 1985 May; 28(5):550-5. PubMed ID: 2985782
[TBL] [Abstract][Full Text] [Related]
12. 5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
Wigerinck P; Pannecouque C; Snoeck R; Claes P; De Clercq E; Herdewijn P
J Med Chem; 1991 Aug; 34(8):2383-9. PubMed ID: 1652017
[TBL] [Abstract][Full Text] [Related]
13. Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
Griengl H; Hayden W; Penn G; De Clercq E; Rosenwirth B
J Med Chem; 1988 Sep; 31(9):1831-9. PubMed ID: 2842506
[TBL] [Abstract][Full Text] [Related]
14. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
Balzarini J; De Clercq E; Baumgartner H; Bodenteich M; Griengl H
Mol Pharmacol; 1990 Mar; 37(3):395-401. PubMed ID: 2156153
[TBL] [Abstract][Full Text] [Related]
15. Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.
Marquardt H; Westendorf J; De Clercq E; Marquardt H
Carcinogenesis; 1985 Aug; 6(8):1207-9. PubMed ID: 3893787
[TBL] [Abstract][Full Text] [Related]
16. Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Balzarini J; Sienaert R; Liekens S; Van Kuilenburg A; Carangio A; Esnouf R; De Clercq E; McGuigan C
Mol Pharmacol; 2002 May; 61(5):1140-5. PubMed ID: 11961132
[TBL] [Abstract][Full Text] [Related]
17. Differential binding affinities of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine for herpes simplex virus-induced and human cellular deoxythymidine kinases.
Zou FC; Dutschman GE; De Clercq E; Cheng YC
Biochem Pharmacol; 1984 Jun; 33(11):1797-800. PubMed ID: 6329218
[TBL] [Abstract][Full Text] [Related]
18. Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
De Clercq E; Descamps J; Balzarini J; Fukui T; Allaudeen HS
Biochem J; 1983 May; 211(2):439-45. PubMed ID: 6307280
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Keizer HJ; De Bruijn EA; Tjaden UR; De Clercq E
J Cancer Res Clin Oncol; 1994; 120(9):545-9. PubMed ID: 8045919
[TBL] [Abstract][Full Text] [Related]
20. (E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity.
Bernaerts R; Desgranges C; De Clercq E
Biochem Pharmacol; 1989 Jun; 38(12):1955-61. PubMed ID: 2545207
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]