248 related articles for article (PubMed ID: 30125603)
1. Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons.
Rivers A; Vaitkus K; Jagadeeswaran R; Ruiz MA; Ibanez V; Ciceri F; Cavalcanti F; Molokie RE; Saunthararajah Y; Engel JD; DeSimone J; Lavelle D
Exp Hematol; 2018 Nov; 67():60-64.e2. PubMed ID: 30125603
[TBL] [Abstract][Full Text] [Related]
2. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).
Rivers A; Vaitkus K; Ibanez V; Ruiz MA; Jagadeeswaran R; Saunthararajah Y; Cui S; Engel JD; DeSimone J; Lavelle D
Haematologica; 2016 Jun; 101(6):688-97. PubMed ID: 26858356
[TBL] [Abstract][Full Text] [Related]
3. RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model.
Rivers A; Vaitkus K; Ruiz MA; Ibanez V; Jagadeeswaran R; Kouznetsova T; DeSimone J; Lavelle D
Exp Hematol; 2015 Jul; 43(7):546-53.e1-3. PubMed ID: 25931013
[TBL] [Abstract][Full Text] [Related]
4. Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis).
Ibanez V; Vaitkus K; Ruiz MA; Lei Z; Maienschein-Cline M; Arbieva Z; Lavelle D
PLoS One; 2023; 18(12):e0289860. PubMed ID: 38134183
[TBL] [Abstract][Full Text] [Related]
5. Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF.
Ibanez V; Vaitkus K; Zhang X; Ramasamy J; Rivers AE; Saunthararajah Y; Molokie R; Lavelle D
Blood Adv; 2023 Aug; 7(15):3891-3902. PubMed ID: 36884303
[TBL] [Abstract][Full Text] [Related]
6. Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data.
Rivers A; Jagadeeswaran R; Lavelle D
Am J Physiol Regul Integr Comp Physiol; 2018 Oct; 315(4):R840-R847. PubMed ID: 30067082
[TBL] [Abstract][Full Text] [Related]
7. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.
Krishnamoorthy S; Pace B; Gupta D; Sturtevant S; Li B; Makala L; Brittain J; Moore N; Vieira BF; Thullen T; Stone I; Li H; Hobbs WE; Light DR
JCI Insight; 2017 Oct; 2(20):. PubMed ID: 29046485
[TBL] [Abstract][Full Text] [Related]
8. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.
Cui S; Lim KC; Shi L; Lee M; Jearawiriyapaisarn N; Myers G; Campbell A; Harro D; Iwase S; Trievel RC; Rivers A; DeSimone J; Lavelle D; Saunthararajah Y; Engel JD
Blood; 2015 Jul; 126(3):386-96. PubMed ID: 26031919
[TBL] [Abstract][Full Text] [Related]
9. Tenofovir disoproxil fumarate induces fetal hemoglobin production in K562 cells and β-YAC transgenic mice: A therapeutic approach for γ-globin induction.
Khan F; Ali H; Musharraf SG
Exp Cell Res; 2020 Sep; 394(2):112168. PubMed ID: 32653411
[TBL] [Abstract][Full Text] [Related]
10. Cilostazol-mediated reversion of γ-globin silencing is associated with a high level of HbF production: A potential therapeutic candidate for β-globin disorders.
Ali H; Khan F; Musharraf SG
Biomed Pharmacother; 2021 Oct; 142():112058. PubMed ID: 34426256
[TBL] [Abstract][Full Text] [Related]
11. Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.
Boosalis MS; Castaneda SA; Trudel M; Mabaera R; White GL; Lowrey CH; Emery DW; Mpollo MS; Shen L; Wargin WA; Bohacek R; Faller DV; Perrine SP
Blood Cells Mol Dis; 2011 Aug; 47(2):107-16. PubMed ID: 21641240
[TBL] [Abstract][Full Text] [Related]
12. Bach1 inhibitor HPP-D mediates γ-globin gene activation in sickle erythroid progenitors.
Palani CD; Zhu X; Alagar M; Attucks OC; Pace BS
Blood Cells Mol Dis; 2024 Jan; 104():102792. PubMed ID: 37633023
[TBL] [Abstract][Full Text] [Related]
13. Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
Pace BS; Perrine S; Li B; Makala L; Xu H; Takezaki M; Wolf RF; Wang A; Xu X; Huang J; Alimardanov A; Tawa GJ; Sangerman J; Faller A; Zheng W; Toney L; Haugabook SJ
Blood Cells Mol Dis; 2021 Jul; 89():102561. PubMed ID: 33744514
[TBL] [Abstract][Full Text] [Related]
14. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.
Zhang Y; Paikari A; Sumazin P; Ginter Summarell CC; Crosby JR; Boerwinkle E; Weiss MJ; Sheehan VA
Blood; 2018 Jul; 132(3):321-333. PubMed ID: 29884740
[TBL] [Abstract][Full Text] [Related]
15. Fetal hemoglobin induction by acetate, a product of butyrate catabolism.
Stamatoyannopoulos G; Blau CA; Nakamoto B; Josephson B; Li Q; Liakopoulou E; Pace B; Papayannopoulou T; Brusilow SW; Dover G
Blood; 1994 Nov; 84(9):3198-204. PubMed ID: 7524768
[TBL] [Abstract][Full Text] [Related]
16. Acyclovir induces fetal hemoglobin via downregulation of γ-globin repressors, BCL11A and SOX6 trans-acting factors.
Ali H; Khan F; Ghulam Musharraf S
Biochem Pharmacol; 2021 Aug; 190():114612. PubMed ID: 34010599
[TBL] [Abstract][Full Text] [Related]
17. 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia.
Koshy M; Dorn L; Bressler L; Molokie R; Lavelle D; Talischy N; Hoffman R; van Overveld W; DeSimone J
Blood; 2000 Oct; 96(7):2379-84. PubMed ID: 11001887
[TBL] [Abstract][Full Text] [Related]
18. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.
Shi L; Cui S; Engel JD; Tanabe O
Nat Med; 2013 Mar; 19(3):291-4. PubMed ID: 23416702
[TBL] [Abstract][Full Text] [Related]
19. Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.
Boosalis MS; Sangerman JI; White GL; Wolf RF; Shen L; Dai Y; White E; Makala LH; Li B; Pace BS; Nouraie M; Faller DV; Perrine SP
PLoS One; 2015; 10(12):e0144660. PubMed ID: 26713848
[TBL] [Abstract][Full Text] [Related]
20. Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease.
Lai ZS; Yeh TK; Chou YC; Hsu T; Lu CT; Kung FC; Hsieh MY; Lin CH; Chen CT; James Shen CK; Jiaang WT
Eur J Med Chem; 2021 Jan; 209():112938. PubMed ID: 33109398
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]