481 related articles for article (PubMed ID: 30135242)
1. Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine.
Akazawa T; Yoshida S; Ohnishi S; Kanazu T; Kawai M; Takahashi K
Drug Metab Dispos; 2018 Nov; 46(11):1497-1506. PubMed ID: 30135242
[TBL] [Abstract][Full Text] [Related]
2. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase-Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells.
Kitaguchi T; Mizota T; Ito M; Ohno K; Kobayashi K; Ogawa I; Qiu S; Iwao T; Hanioka N; Tanaka M; Matsunaga T
Drug Metab Dispos; 2022 Jan; 50(1):17-23. PubMed ID: 34670778
[TBL] [Abstract][Full Text] [Related]
3. Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.
Bruyère A; Declèves X; Bouzom F; Ball K; Marques C; Treton X; Pocard M; Valleur P; Bouhnik Y; Panis Y; Scherrmann JM; Mouly S
Mol Pharm; 2010 Oct; 7(5):1596-607. PubMed ID: 20604570
[TBL] [Abstract][Full Text] [Related]
4. Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs.
Dahan A; Amidon GL
Mol Pharm; 2009; 6(1):19-28. PubMed ID: 19248230
[TBL] [Abstract][Full Text] [Related]
5. Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.
Dahan A; Amidon GL
Am J Physiol Gastrointest Liver Physiol; 2009 Aug; 297(2):G371-7. PubMed ID: 19541926
[TBL] [Abstract][Full Text] [Related]
6. Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model.
Darwich AS; Neuhoff S; Jamei M; Rostami-Hodjegan A
Curr Drug Metab; 2010 Nov; 11(9):716-29. PubMed ID: 21189140
[TBL] [Abstract][Full Text] [Related]
7. Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells.
Kabeya T; Mima S; Imakura Y; Miyashita T; Ogura I; Yamada T; Yasujima T; Yuasa H; Iwao T; Matsunaga T
Drug Metab Pharmacokinet; 2020 Aug; 35(4):374-382. PubMed ID: 32651148
[TBL] [Abstract][Full Text] [Related]
8. Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats.
Zhang H; Yao M; Morrison RA; Chong S
Arch Pharm Res; 2003 Sep; 26(9):768-72. PubMed ID: 14560928
[TBL] [Abstract][Full Text] [Related]
9. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.
Cao X; Gibbs ST; Fang L; Miller HA; Landowski CP; Shin HC; Lennernas H; Zhong Y; Amidon GL; Yu LX; Sun D
Pharm Res; 2006 Aug; 23(8):1675-86. PubMed ID: 16841194
[TBL] [Abstract][Full Text] [Related]
10. Intestinal absorption mechanisms of 2'-deoxy-2'-β-fluoro-4'-azidocytidine, a cytidine analog for AIDS treatment, and its interaction with P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein.
Liu Y; Liu B; Zhang Y; Peng Y; Huang C; Wang N; Jiang J; Wang Q; Chang J
Eur J Pharm Sci; 2017 Jul; 105():150-158. PubMed ID: 28487144
[TBL] [Abstract][Full Text] [Related]
11. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism.
Yamaura Y; Chapron BD; Wang Z; Himmelfarb J; Thummel KE
Drug Metab Dispos; 2016 Mar; 44(3):329-35. PubMed ID: 26700954
[TBL] [Abstract][Full Text] [Related]
12. Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.
Suzuki H; Sugiyama Y
Eur J Pharm Sci; 2000 Nov; 12(1):3-12. PubMed ID: 11121729
[TBL] [Abstract][Full Text] [Related]
13. Intestinal absorption and activation of decitabine amino acid ester prodrugs mediated by peptide transporter PEPT1 and enterocyte enzymes.
Tao W; Zhao D; Sun M; Wang Z; Lin B; Bao Y; Li Y; He Z; Sun Y; Sun J
Int J Pharm; 2018 Apr; 541(1-2):64-71. PubMed ID: 29471144
[TBL] [Abstract][Full Text] [Related]
14. Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics.
Yan Z; Sun J; Chang Y; Liu Y; Fu Q; Xu Y; Sun Y; Pu X; Zhang Y; Jing Y; Yin S; Zhu M; Wang Y; He Z
Mol Pharm; 2011 Apr; 8(2):319-29. PubMed ID: 21280612
[TBL] [Abstract][Full Text] [Related]
15. Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans.
Li X; Sun J; Guo Z; Zhong D; Chen X
Drug Metab Dispos; 2019 Aug; 47(8):843-853. PubMed ID: 31076412
[TBL] [Abstract][Full Text] [Related]
16. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells.
Ulvestad M; Nordell P; Asplund A; Rehnström M; Jacobsson S; Holmgren G; Davidson L; Brolén G; Edsbagge J; Björquist P; Küppers-Munther B; Andersson TB
Biochem Pharmacol; 2013 Sep; 86(5):691-702. PubMed ID: 23856292
[TBL] [Abstract][Full Text] [Related]
17. Transport of levovirin prodrugs in the human intestinal Caco-2 cell line.
Li F; Hong L; Mau CI; Chan R; Hendricks T; Dvorak C; Yee C; Harris J; Alfredson T
J Pharm Sci; 2006 Jun; 95(6):1318-25. PubMed ID: 16634069
[TBL] [Abstract][Full Text] [Related]
18. Targeting intestinal transporters for optimizing oral drug absorption.
Varma MV; Ambler CM; Ullah M; Rotter CJ; Sun H; Litchfield J; Fenner KS; El-Kattan AF
Curr Drug Metab; 2010 Nov; 11(9):730-42. PubMed ID: 21189135
[TBL] [Abstract][Full Text] [Related]
19. Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine.
Ohura K; Nishiyama H; Saco S; Kurokawa K; Imai T
Drug Metab Dispos; 2016 Dec; 44(12):1890-1898. PubMed ID: 27638507
[TBL] [Abstract][Full Text] [Related]
20. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine.
Dahan A; Sabit H; Amidon GL
Drug Metab Dispos; 2009 Oct; 37(10):2028-36. PubMed ID: 19589874
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
