BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

246 related articles for article (PubMed ID: 30135302)

  • 1. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
    Wang ZH; Wu W; Kang SS; Liu X; Wu Z; Peng J; Yu SP; Manfredsson FP; Sandoval IM; Liu X; Wang JZ; Ye K
    JCI Insight; 2018 Aug; 3(16):. PubMed ID: 30135302
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
    Xiang J; Wang ZH; Ahn EH; Liu X; Yu SP; Manfredsson FP; Sandoval IM; Ju G; Wu S; Ye K
    Proc Natl Acad Sci U S A; 2019 Apr; 116(18):9094-9102. PubMed ID: 31004063
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
    Zhang Z; Song M; Liu X; Kang SS; Kwon IS; Duong DM; Seyfried NT; Hu WT; Liu Z; Wang JZ; Cheng L; Sun YE; Yu SP; Levey AI; Ye K
    Nat Med; 2014 Nov; 20(11):1254-62. PubMed ID: 25326800
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Initiation of Parkinson's disease from gut to brain by δ-secretase.
    Ahn EH; Kang SS; Liu X; Chen G; Zhang Z; Chandrasekharan B; Alam AM; Neish AS; Cao X; Ye K
    Cell Res; 2020 Jan; 30(1):70-87. PubMed ID: 31649329
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
    Zhang X; Zou L; Meng L; Xiong M; Pan L; Chen G; Zheng Y; Xiong J; Wang Z; Duong DM; Zhang Z; Cao X; Wang T; Tang L; Ye K; Zhang Z
    Elife; 2021 May; 10():. PubMed ID: 34018922
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia.
    Basurto-Islas G; Gu JH; Tung YC; Liu F; Iqbal K
    J Alzheimers Dis; 2018; 63(2):821-833. PubMed ID: 29689717
    [TBL] [Abstract][Full Text] [Related]  

  • 7. α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.
    Kang SS; Ahn EH; Zhang Z; Liu X; Manfredsson FP; Sandoval IM; Dhakal S; Iuvone PM; Cao X; Ye K
    EMBO J; 2018 Jun; 37(12):. PubMed ID: 29769405
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.
    Zhang Z; Kang SS; Liu X; Ahn EH; Zhang Z; He L; Iuvone PM; Duong DM; Seyfried NT; Benskey MJ; Manfredsson FP; Jin L; Sun YE; Wang JZ; Ye K
    Nat Struct Mol Biol; 2017 Aug; 24(8):632-642. PubMed ID: 28671665
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
    Wang ZH; Liu P; Liu X; Manfredsson FP; Sandoval IM; Yu SP; Wang JZ; Ye K
    Mol Cell; 2017 Sep; 67(5):812-825.e5. PubMed ID: 28826672
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Asparagine endopeptidase cleaves tau at N167 after uptake into microglia.
    Behrendt A; Bichmann M; Ercan-Herbst E; Haberkant P; Schöndorf DC; Wolf M; Fahim SA; Murolo E; Ehrnhoefer DE
    Neurobiol Dis; 2019 Oct; 130():104518. PubMed ID: 31229689
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.
    Yu T; Wan F; Liu C; Zhang X; Liu Z; Zhang J; Xiong J; Wang T; Zhang Z
    Eur J Pharmacol; 2020 Dec; 888():173586. PubMed ID: 32971086
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
    Hu W; Tung YC; Zhang Y; Liu F; Iqbal K
    J Alzheimers Dis; 2018; 64(3):709-722. PubMed ID: 29889065
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.
    Ramesh Babu J; Lamar Seibenhener M; Peng J; Strom AL; Kemppainen R; Cox N; Zhu H; Wooten MC; Diaz-Meco MT; Moscat J; Wooten MW
    J Neurochem; 2008 Jul; 106(1):107-20. PubMed ID: 18346206
    [TBL] [Abstract][Full Text] [Related]  

  • 14. c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.
    Jiang Y; Li L; Wu R; Wu L; Zhang B; Wang JZ; Liu R; Liu F; Wang J; Wang X
    J Biol Chem; 2023 Dec; 299(12):105462. PubMed ID: 37977223
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading.
    Wu Z; Zhu R; Yu Y; Wang J; Hu X; Xu W; Ren Y; Li C; Zeng Z; Ma B; Xie N; Lin G; Ma B; Zhu R; Ye K; Cheng L
    Prog Neurobiol; 2023 Aug; 227():102467. PubMed ID: 37257680
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
    Zou L; Zhang X; Xiong M; Meng L; Tian Y; Pan L; Yuan X; Chen G; Wang Z; Bu L; Yao Z; Zhang Z; Ye K; Zhang Z
    Neurobiol Dis; 2021 Jul; 154():105326. PubMed ID: 33677035
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.
    Zhang Z; Xie M; Ye K
    Expert Opin Ther Targets; 2016 Oct; 20(10):1237-45. PubMed ID: 27115710
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition and analysis of their phosphorylation signaling pathways.
    Cui Y; Wang Y; Li H; Li Q; Yu Y; Xu X; Xu B; Liu T
    Oncotarget; 2016 Jun; 7(23):34356-70. PubMed ID: 27102302
    [TBL] [Abstract][Full Text] [Related]  

  • 19. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.
    Lee VM; Giasson BI; Trojanowski JQ
    Trends Neurosci; 2004 Mar; 27(3):129-34. PubMed ID: 15036877
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
    Wang ZH; Liu P; Liu X; Yu SP; Wang JZ; Ye K
    J Exp Med; 2018 Dec; 215(12):3038-3056. PubMed ID: 30373880
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.