These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 30177379)

  • 1. Current trends in Hedgehog signaling pathway inhibition by small molecules.
    Ghirga F; Mori M; Infante P
    Bioorg Med Chem Lett; 2018 Oct; 28(19):3131-3140. PubMed ID: 30177379
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Overcoming the emerging drug resistance of smoothened: an overview of small-molecule SMO antagonists with antiresistance activity.
    Zhang H; Sun Z; Liu Z; Song C
    Future Med Chem; 2018 Dec; 10(24):2855-2875. PubMed ID: 30557039
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hedgehog signaling pathway inhibitors: an updated patent review (2015-present).
    Quaglio D; Infante P; Di Marcotullio L; Botta B; Mori M
    Expert Opin Ther Pat; 2020 Apr; 30(4):235-250. PubMed ID: 32070165
    [No Abstract]   [Full Text] [Related]  

  • 4. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
    Gruber W; Hutzinger M; Elmer DP; Parigger T; Sternberg C; Cegielkowski L; Zaja M; Leban J; Michel S; Hamm S; Vitt D; Aberger F
    Oncotarget; 2016 Feb; 7(6):7134-48. PubMed ID: 26784250
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeting GLI factors to inhibit the Hedgehog pathway.
    Infante P; Alfonsi R; Botta B; Mori M; Di Marcotullio L
    Trends Pharmacol Sci; 2015 Aug; 36(8):547-58. PubMed ID: 26072120
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.
    Manetti F; Petricci E
    Expert Opin Ther Pat; 2016; 26(4):529-35. PubMed ID: 26666870
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.
    Gruber W; Peer E; Elmer DP; Sternberg C; Tesanovic S; Del Burgo P; Coni S; Canettieri G; Neureiter D; Bartz R; Kohlhof H; Vitt D; Aberger F
    Int J Cancer; 2018 Mar; 142(5):968-975. PubMed ID: 29055107
    [TBL] [Abstract][Full Text] [Related]  

  • 8. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
    Hoch L; Faure H; Roudaut H; Schoenfelder A; Mann A; Girard N; Bihannic L; Ayrault O; Petricci E; Taddei M; Rognan D; Ruat M
    FASEB J; 2015 May; 29(5):1817-29. PubMed ID: 25636740
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of Hedgehog Antagonists for Cancer Therapy.
    Khatra H; Bose C; Sinha S
    Curr Med Chem; 2017; 24(19):2033-2058. PubMed ID: 28302010
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.
    Berardozzi S; Bernardi F; Infante P; Ingallina C; Toscano S; De Paolis E; Alfonsi R; Caimano M; Botta B; Mori M; Di Marcotullio L; Ghirga F
    Eur J Med Chem; 2018 Aug; 156():554-562. PubMed ID: 30025349
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.
    Infante P; Alfonsi R; Ingallina C; Quaglio D; Ghirga F; D'Acquarica I; Bernardi F; Di Magno L; Canettieri G; Screpanti I; Gulino A; Botta B; Mori M; Di Marcotullio L
    Cell Death Dis; 2016 Sep; 7(9):e2376. PubMed ID: 27899820
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hedgehog pathway and smoothened inhibitors in cancer therapies.
    Chahal KK; Parle M; Abagyan R
    Anticancer Drugs; 2018 Jun; 29(5):387-401. PubMed ID: 29537987
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.
    Tian N; Wu H; Zhang H; Yang D; Lv L; Yang Z; Zhang T; Quan D; Zhou L; Xie Y; Xu Y; Wei N; Zhang J; Chen M; Schmitz JC; Tian Y; Wu S
    Bioorg Med Chem; 2020 Aug; 28(16):115584. PubMed ID: 32690258
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Interference with SMO increases chemotherapy drug sensitivity of A2780/DDP cells by inhibiting the Hh/Gli signaling pathway.
    Ma S; Liu D; Tan W; Du B; Liu W; Li W; Jiao Y
    J Cell Biochem; 2020 Jun; 121(5-6):3256-3265. PubMed ID: 31904145
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hedgehog Signaling: From Basic Biology to Cancer Therapy.
    Wu F; Zhang Y; Sun B; McMahon AP; Wang Y
    Cell Chem Biol; 2017 Mar; 24(3):252-280. PubMed ID: 28286127
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol.
    Wang F; Stappenbeck F; Matsui W; Parhami F
    J Cell Biochem; 2017 Mar; 118(3):499-509. PubMed ID: 27490478
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.
    Grzelak CA; Martelotto LG; Sigglekow ND; Patkunanathan B; Ajami K; Calabro SR; Dwyer BJ; Tirnitz-Parker JE; Watkins DN; Warner FJ; Shackel NA; McCaughan GW
    J Hepatol; 2014 Jan; 60(1):143-51. PubMed ID: 23978713
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A synthetic combinatorial approach to disabling deviant Hedgehog signaling.
    Fan CW; Yarravarapu N; Shi H; Kulak O; Kim J; Chen C; Lum L
    Sci Rep; 2018 Jan; 8(1):1133. PubMed ID: 29348431
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol, rather as a BH3 mimetic.
    Wang J; Zhang Y; Huang WJ; Yang J; Tang WG; Huang TM; Tan WF
    Acta Pharmacol Sin; 2021 Jun; 42(6):1005-1013. PubMed ID: 32855528
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
    Li QR; Zhao H; Zhang XS; Lang H; Yu K
    Acta Pharmacol Sin; 2019 Feb; 40(2):257-267. PubMed ID: 29777201
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.