BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

326 related articles for article (PubMed ID: 30179224)

  • 1. Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.
    Su D; Ma S; Shan L; Wang Y; Wang Y; Cao C; Liu B; Yang C; Wang L; Tian S; Ding X; Liu X; Yu N; Song N; Liu L; Yang S; Zhang Q; Yang F; Zhang K; Shi L
    J Clin Invest; 2018 Oct; 128(10):4280-4296. PubMed ID: 30179224
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.
    Chapman JR; Jackson SP
    EMBO Rep; 2008 Aug; 9(8):795-801. PubMed ID: 18583988
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.
    Pfeiffer A; Luijsterburg MS; Acs K; Wiegant WW; Helfricht A; Herzog LK; Minoia M; Böttcher C; Salomons FA; van Attikum H; Dantuma NP
    EMBO J; 2017 Apr; 36(8):1066-1083. PubMed ID: 28275011
    [TBL] [Abstract][Full Text] [Related]  

  • 4. USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.
    Zhu Q; Sharma N; He J; Wani G; Wani AA
    Cell Cycle; 2015; 14(9):1413-25. PubMed ID: 25894431
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP80.
    Strauss C; Goldberg M
    Cell Cycle; 2011 Sep; 10(17):2850-7. PubMed ID: 21857162
    [TBL] [Abstract][Full Text] [Related]  

  • 6. MDC1 is a mediator of the mammalian DNA damage checkpoint.
    Stewart GS; Wang B; Bignell CR; Taylor AM; Elledge SJ
    Nature; 2003 Feb; 421(6926):961-6. PubMed ID: 12607005
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
    Mochan TA; Venere M; DiTullio RA; Halazonetis TD
    Cancer Res; 2003 Dec; 63(24):8586-91. PubMed ID: 14695167
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.
    Shi W; Ma Z; Willers H; Akhtar K; Scott SP; Zhang J; Powell S; Zhang J
    J Biol Chem; 2008 Nov; 283(46):31608-16. PubMed ID: 18757370
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.
    Xu C; Wu L; Cui G; Botuyan MV; Chen J; Mer G
    J Mol Biol; 2008 Aug; 381(2):361-72. PubMed ID: 18582474
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.
    Melander F; Bekker-Jensen S; Falck J; Bartek J; Mailand N; Lukas J
    J Cell Biol; 2008 Apr; 181(2):213-26. PubMed ID: 18411307
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.
    Lee KY; Im JS; Shibata E; Dutta A
    Mol Cell; 2017 Oct; 68(1):61-75.e5. PubMed ID: 28943310
    [TBL] [Abstract][Full Text] [Related]  

  • 12. JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.
    Watanabe S; Watanabe K; Akimov V; Bartkova J; Blagoev B; Lukas J; Bartek J
    Nat Struct Mol Biol; 2013 Dec; 20(12):1425-33. PubMed ID: 24240613
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Downregulation of MDC1 and 53BP1 by short hairpin RNA enhances radiosensitivity in laryngeal carcinoma cells.
    Gou Q; Xie Y; Liu L; Xie K; Wu Y; Wang Q; Wang Z; Li P
    Oncol Rep; 2015 Jul; 34(1):251-7. PubMed ID: 25976740
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dual-utility NLS drives RNF169-dependent DNA damage responses.
    An L; Jiang Y; Ng HH; Man EP; Chen J; Khoo US; Gong Q; Huen MS
    Proc Natl Acad Sci U S A; 2017 Apr; 114(14):E2872-E2881. PubMed ID: 28325877
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.
    Nagy Z; Kalousi A; Furst A; Koch M; Fischer B; Soutoglou E
    PLoS Genet; 2016 Feb; 12(2):e1005791. PubMed ID: 26845027
    [TBL] [Abstract][Full Text] [Related]  

  • 16. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours.
    Bartkova J; Horejsí Z; Sehested M; Nesland JM; Rajpert-De Meyts E; Skakkebaek NE; Stucki M; Jackson S; Lukas J; Bartek J
    Oncogene; 2007 Nov; 26(53):7414-22. PubMed ID: 17546051
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage.
    Eliezer Y; Argaman L; Rhie A; Doherty AJ; Goldberg M
    J Biol Chem; 2009 Jan; 284(1):426-435. PubMed ID: 18986980
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci.
    Mok MT; Henderson BR
    Radiother Oncol; 2012 Jun; 103(3):415-20. PubMed ID: 22633816
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.
    Lukas C; Melander F; Stucki M; Falck J; Bekker-Jensen S; Goldberg M; Lerenthal Y; Jackson SP; Bartek J; Lukas J
    EMBO J; 2004 Jul; 23(13):2674-83. PubMed ID: 15201865
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis.
    Wang Q; Ma S; Song N; Li X; Liu L; Yang S; Ding X; Shan L; Zhou X; Su D; Wang Y; Zhang Q; Liu X; Yu N; Zhang K; Shang Y; Yao Z; Shi L
    J Clin Invest; 2016 Jun; 126(6):2205-20. PubMed ID: 27183383
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.