These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 30207721)

  • 1. A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.
    Harrison JR; Brand S; Smith V; Robinson DA; Thompson S; Smith A; Davies K; Mok N; Torrie LS; Collie I; Hallyburton I; Norval S; Simeons FRC; Stojanovski L; Frearson JA; Brenk R; Wyatt PG; Gilbert IH; Read KD
    J Med Chem; 2018 Sep; 61(18):8374-8389. PubMed ID: 30207721
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
    Bayliss T; Robinson DA; Smith VC; Brand S; McElroy SP; Torrie LS; Mpamhanga C; Norval S; Stojanovski L; Brenk R; Frearson JA; Read KD; Gilbert IH; Wyatt PG
    J Med Chem; 2017 Dec; 60(23):9790-9806. PubMed ID: 29125744
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
    Brand S; Norcross NR; Thompson S; Harrison JR; Smith VC; Robinson DA; Torrie LS; McElroy SP; Hallyburton I; Norval S; Scullion P; Stojanovski L; Simeons FR; van Aalten D; Frearson JA; Brenk R; Fairlamb AH; Ferguson MA; Wyatt PG; Gilbert IH; Read KD
    J Med Chem; 2014 Dec; 57(23):9855-69. PubMed ID: 25412409
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
    Brand S; Cleghorn LA; McElroy SP; Robinson DA; Smith VC; Hallyburton I; Harrison JR; Norcross NR; Spinks D; Bayliss T; Norval S; Stojanovski L; Torrie LS; Frearson JA; Brenk R; Fairlamb AH; Ferguson MA; Read KD; Wyatt PG; Gilbert IH
    J Med Chem; 2012 Jan; 55(1):140-52. PubMed ID: 22148754
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.
    Cleghorn LA; Albrecht S; Stojanovski L; Simeons FR; Norval S; Kime R; Collie IT; De Rycker M; Campbell L; Hallyburton I; Frearson JA; Wyatt PG; Read KD; Gilbert IH
    J Med Chem; 2015 Oct; 58(19):7695-706. PubMed ID: 26418485
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT.
    Ciammaichella A; Ferrigno F; Basta A; D'Amico M; Biancofiore I; Nardi V; Ponzi S; Graziani R; Gennari N; Vittoria Orsale M; Fini I; Paonessa G; Summa V; Harper S; Ontoria JM
    Bioorg Med Chem Lett; 2020 Jun; 30(12):127207. PubMed ID: 32354566
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
    Spinks D; Smith V; Thompson S; Robinson DA; Luksch T; Smith A; Torrie LS; McElroy S; Stojanovski L; Norval S; Collie IT; Hallyburton I; Rao B; Brand S; Brenk R; Frearson JA; Read KD; Wyatt PG; Gilbert IH
    ChemMedChem; 2015 Nov; 10(11):1821-36. PubMed ID: 26395087
    [TBL] [Abstract][Full Text] [Related]  

  • 8. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
    Frearson JA; Brand S; McElroy SP; Cleghorn LA; Smid O; Stojanovski L; Price HP; Guther ML; Torrie LS; Robinson DA; Hallyburton I; Mpamhanga CP; Brannigan JA; Wilkinson AJ; Hodgkinson M; Hui R; Qiu W; Raimi OG; van Aalten DM; Brenk R; Gilbert IH; Read KD; Fairlamb AH; Ferguson MA; Smith DF; Wyatt PG
    Nature; 2010 Apr; 464(7289):728-32. PubMed ID: 20360736
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.
    Wu P; Zhang J; Meng Q; Nare B; Jacobs RT; Zhou H
    Eur J Med Chem; 2014 Jun; 81():59-75. PubMed ID: 24826816
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.
    Ferrigno F; Biancofiore I; Malancona S; Ponzi S; Paonessa G; Graziani R; Bresciani A; Gennari N; Di Marco A; Kaiser M; Summa V; Harper S; Ontoria JM
    Bioorg Med Chem Lett; 2018 Dec; 28(23-24):3689-3692. PubMed ID: 30482621
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis.
    Monti L; Wang SC; Oukoloff K; Smith AB; Brunden KR; Caffrey CR; Ballatore C
    ChemMedChem; 2018 Sep; 13(17):1751-1754. PubMed ID: 29969537
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
    Ferrins L; Rahmani R; Sykes ML; Jones AJ; Avery VM; Teston E; Almohaywi B; Yin J; Smith J; Hyland C; White KL; Ryan E; Campbell M; Charman SA; Kaiser M; Baell JB
    Eur J Med Chem; 2013 Aug; 66():450-65. PubMed ID: 23831695
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
    Urbaniak MD; Tabudravu JN; Msaki A; Matera KM; Brenk R; Jaspars M; Ferguson MA
    Bioorg Med Chem Lett; 2006 Nov; 16(22):5744-7. PubMed ID: 16962325
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fluorine walk: The impact of fluorine in quinolone amides on their activity against African sleeping sickness.
    Berninger M; Erk C; Fuß A; Skaf J; Al-Momani E; Israel I; Raschig M; Güntzel P; Samnick S; Holzgrabe U
    Eur J Med Chem; 2018 May; 152():377-391. PubMed ID: 29742443
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
    Klug DM; Mavrogiannaki EM; Forbes KC; Silva L; Diaz-Gonzalez R; Pérez-Moreno G; Ceballos-Pérez G; Garcia-Hernández R; Bosch-Navarrete C; Cordón-Obras C; Gómez-Liñán C; Saura A; Momper JD; Martinez-Martinez MS; Manzano P; Syed A; El-Sakkary N; Caffrey CR; Gamarro F; Ruiz-Perez LM; Gonzalez Pacanowska D; Ferrins L; Navarro M; Pollastri MP
    J Med Chem; 2021 Jul; 64(13):9404-9430. PubMed ID: 34156862
    [TBL] [Abstract][Full Text] [Related]  

  • 16. From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.
    Devine WG; Diaz-Gonzalez R; Ceballos-Perez G; Rojas D; Satoh T; Tear W; Ranade RM; Barros-Álvarez X; Hol WG; Buckner FS; Navarro M; Pollastri MP
    ACS Infect Dis; 2017 Mar; 3(3):225-236. PubMed ID: 28110521
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.
    Maiwald F; Benítez D; Charquero D; Dar MA; Erdmann H; Preu L; Koch O; Hölscher C; Loaëc N; Meijer L; Comini MA; Kunick C
    Eur J Med Chem; 2014 Aug; 83():274-83. PubMed ID: 24973661
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
    Kelly JM; Taylor MC; Horn D; Loza E; Kalvinsh I; Björkling F
    Bioorg Med Chem Lett; 2012 Mar; 22(5):1886-90. PubMed ID: 22326398
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.
    Cestari I; Stuart K
    J Biol Chem; 2013 May; 288(20):14256-14263. PubMed ID: 23548908
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Anti-trypanosomal activity of doubly modified salinomycin derivatives.
    Antoszczak M; Steverding D; Sulik M; Janczak J; Huczyński A
    Eur J Med Chem; 2019 Jul; 173():90-98. PubMed ID: 30986574
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.