BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

271 related articles for article (PubMed ID: 30222362)

  • 1. Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
    Chen EC; Broccatelli F; Plise E; Chen B; Liu L; Cheong J; Zhang S; Jorski J; Gaffney K; Umemoto KK; Salphati L
    Mol Pharm; 2018 Nov; 15(11):5103-5113. PubMed ID: 30222362
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
    Ye D; Harder A; Fang Z; Weinheimer M; Laplanche L; Mezler M
    Pharm Res; 2020 Sep; 37(10):194. PubMed ID: 32918191
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport.
    Kuteykin-Teplyakov K; Luna-Tortós C; Ambroziak K; Löscher W
    Br J Pharmacol; 2010 Jul; 160(6):1453-63. PubMed ID: 20590635
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
    Karlgren M; Simoff I; Backlund M; Wegler C; Keiser M; Handin N; Müller J; Lundquist P; Jareborg AC; Oswald S; Artursson P
    J Pharm Sci; 2017 Sep; 106(9):2909-2913. PubMed ID: 28450237
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.
    Wegler C; Gazit M; Issa K; Subramaniam S; Artursson P; Karlgren M
    J Pharm Sci; 2021 Jan; 110(1):388-396. PubMed ID: 33007277
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9.
    Simoff I; Karlgren M; Backlund M; Lindström AC; Gaugaz FZ; Matsson P; Artursson P
    J Pharm Sci; 2016 Feb; 105(2):1017-1021. PubMed ID: 26869442
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.
    Tang F; Borchardt RT
    Pharm Res; 2002 Jun; 19(6):787-93. PubMed ID: 12134948
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Isolation of MDCK cells with low expression of
    Bokulić A; Padovan J; Stupin-Polančec D; Milić A
    Acta Pharm; 2022 Jun; 72(2):275-288. PubMed ID: 36651516
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT).
    Guo A; Marinaro W; Hu P; Sinko PJ
    Drug Metab Dispos; 2002 Apr; 30(4):457-63. PubMed ID: 11901101
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
    Tang F; Horie K; Borchardt RT
    Pharm Res; 2002 Jun; 19(6):765-72. PubMed ID: 12134945
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.
    Tang F; Borchardt RT
    Pharm Res; 2002 Jun; 19(6):780-6. PubMed ID: 12134947
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK model.
    Karyekar CS; Eddington ND; Garimella TS; Gubbins PO; Dowling TC
    Pharmacotherapy; 2003 Apr; 23(4):436-42. PubMed ID: 12680473
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Utilizing a Dual Human Transporter MDCKII-MDR1-BCRP Cell Line to Assess Efflux at the Blood Brain Barrier.
    Colclough N; Alluri RV; Tucker JW; Gozalpour E; Li D; Du H; Li W; Harlfinger S; O'Neill DJ; Sproat GG; Chen K; Yan Y; McGinnity DF
    Drug Metab Dispos; 2024 Jan; 52(2):95-105. PubMed ID: 38071533
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities.
    Sato S; Tohyama K; Kosugi Y
    Eur J Pharm Sci; 2020 Jan; 142():105119. PubMed ID: 31682973
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines.
    Mukkavilli R; Jadhav G; Vangala S
    Curr Pharm Biotechnol; 2017; 18(14):1151-1158. PubMed ID: 29521222
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.
    Feng B; West M; Patel NC; Wager T; Hou X; Johnson J; Tremaine L; Liras J
    J Pharm Sci; 2019 Jul; 108(7):2476-2483. PubMed ID: 30794795
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.
    Jin X; Luong TL; Reese N; Gaona H; Collazo-Velez V; Vuong C; Potter B; Sousa JC; Olmeda R; Li Q; Xie L; Zhang J; Zhang P; Reichard G; Melendez V; Marcsisin SR; Pybus BS
    J Pharmacol Toxicol Methods; 2014; 70(2):188-94. PubMed ID: 25150934
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism.
    Kwatra D; Budda B; Vadlapudi AD; Vadlapatla RK; Pal D; Mitra AK
    Mol Pharm; 2012 Jul; 9(7):1877-86. PubMed ID: 22676443
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.
    Taub ME; Podila L; Ely D; Almeida I
    Drug Metab Dispos; 2005 Nov; 33(11):1679-87. PubMed ID: 16093365
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice.
    Ozgür B; Saaby L; Janfelt C; Langthaler K; Eneberg E; Jacobsen AM; Badolo L; Montanari D; Brodin B
    Eur J Pharm Biopharm; 2021 Dec; 169():211-219. PubMed ID: 34756975
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.