BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 30224054)

  • 1. Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450
    Geronimo I; Denning CA; Heidary DK; Glazer EC; Payne CM
    Biophys J; 2018 Oct; 115(7):1251-1263. PubMed ID: 30224054
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
    Geronimo I; Denning CA; Rogers WE; Othman T; Huxford T; Heidary DK; Glazer EC; Payne CM
    Biochemistry; 2016 Jun; 55(25):3594-606. PubMed ID: 27267136
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hoodwinking Cytochrome P450BM3 into Hydroxylating Non-Native Substrates by Exploiting Its Substrate Misrecognition.
    Shoji O; Aiba Y; Watanabe Y
    Acc Chem Res; 2019 Apr; 52(4):925-934. PubMed ID: 30888147
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel haem co-ordination variants of flavocytochrome P450BM3.
    Girvan HM; Toogood HS; Littleford RE; Seward HE; Smith WE; Ekanem IS; Leys D; Cheesman MR; Munro AW
    Biochem J; 2009 Jan; 417(1):65-76. PubMed ID: 18721129
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites.
    Beyer N; Kulig JK; Fraaije MW; Hayes MA; Janssen DB
    Chembiochem; 2018 Feb; 19(4):326-337. PubMed ID: 29181885
    [TBL] [Abstract][Full Text] [Related]  

  • 6. P450
    Beyer N; Kulig JK; Bartsch A; Hayes MA; Janssen DB; Fraaije MW
    Appl Microbiol Biotechnol; 2017 Mar; 101(6):2319-2331. PubMed ID: 27900443
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expanding the applicability of cytochrome P450s and other haemoproteins.
    Ariyasu S; Stanfield JK; Aiba Y; Shoji O
    Curr Opin Chem Biol; 2020 Dec; 59():155-163. PubMed ID: 32781431
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A highly active single-mutation variant of P450BM3 (CYP102A1).
    Whitehouse CJ; Bell SG; Yang W; Yorke JA; Blanford CF; Strong AJ; Morse EJ; Bartlam M; Rao Z; Wong LL
    Chembiochem; 2009 Jul; 10(10):1654-6. PubMed ID: 19492389
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain.
    Murataliev MB; Feyereisen R
    Biochemistry; 1996 Nov; 35(47):15029-37. PubMed ID: 8942669
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.
    Huang WC; Westlake AC; Maréchal JD; Joyce MG; Moody PC; Roberts GC
    J Mol Biol; 2007 Oct; 373(3):633-51. PubMed ID: 17868686
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytochrome P450-The Wonderful Nanomachine Revealed through Dynamic Simulations of the Catalytic Cycle.
    Dubey KD; Shaik S
    Acc Chem Res; 2019 Feb; 52(2):389-399. PubMed ID: 30633519
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Improving the activity of cytochrome P450 BM-3 catalyzing indole hydroxylation by directed evolution.
    Pengpai Z; Sheng H; Lehe M; Yinlin L; Zhihua J; Guixiang H
    Appl Biochem Biotechnol; 2013 Sep; 171(1):93-103. PubMed ID: 23817788
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Insights into an efficient light-driven hybrid P450 BM3 enzyme from crystallographic, spectroscopic and biochemical studies.
    Spradlin J; Lee D; Mahadevan S; Mahomed M; Tang L; Lam Q; Colbert A; Shafaat OS; Goodin D; Kloos M; Kato M; Cheruzel LE
    Biochim Biophys Acta; 2016 Dec; 1864(12):1732-1738. PubMed ID: 27639964
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Insights into electron leakage in the reaction cycle of cytochrome P450 BM3 revealed by kinetic modeling and mutagenesis.
    Lim JB; Barker KA; Eller KA; Jiang L; Molina V; Saifee JF; Sikes HD
    Protein Sci; 2015 Nov; 24(11):1874-83. PubMed ID: 26311413
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Free energy calculations give insight into the stereoselective hydroxylation of α-ionones by engineered cytochrome P450 BM3 mutants.
    de Beer SB; Venkataraman H; Geerke DP; Oostenbrink C; Vermeulen NP
    J Chem Inf Model; 2012 Aug; 52(8):2139-48. PubMed ID: 22765880
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain.
    Murataliev MB; Klein M; Fulco A; Feyereisen R
    Biochemistry; 1997 Jul; 36(27):8401-12. PubMed ID: 9204888
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol.
    Frydenvang K; Verkade-Vreeker MCA; Dohmen F; Commandeur JNM; Rafiq M; Mirza O; Jørgensen FS; Geerke DP
    PLoS One; 2019; 14(5):e0217292. PubMed ID: 31125381
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hydroxylation of anilides by engineered cytochrome P450
    O'Hanlon JA; Ren X; Morris M; Wong LL; Robertson J
    Org Biomol Chem; 2017 Oct; 15(41):8780-8787. PubMed ID: 29019509
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.
    Park SH; Kim DH; Kim D; Kim DH; Jung HC; Pan JG; Ahn T; Kim D; Yun CH
    Drug Metab Dispos; 2010 May; 38(5):732-9. PubMed ID: 20100815
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular Dynamics and QM/MM Calculations Predict the Substrate-Induced Gating of Cytochrome P450 BM3 and the Regio- and Stereoselectivity of Fatty Acid Hydroxylation.
    Dubey KD; Wang B; Shaik S
    J Am Chem Soc; 2016 Jan; 138(3):837-45. PubMed ID: 26716578
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.