BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

223 related articles for article (PubMed ID: 30224519)

  • 1. Human DnaJB6 Antiamyloid Chaperone Protects Yeast from Polyglutamine Toxicity Separately from Spatial Segregation of Aggregates.
    Kumar J; Kline NL; Masison DC
    Mol Cell Biol; 2018 Dec; 38(23):. PubMed ID: 30224519
    [TBL] [Abstract][Full Text] [Related]  

  • 2. DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.
    Månsson C; Kakkar V; Monsellier E; Sourigues Y; Härmark J; Kampinga HH; Melki R; Emanuelsson C
    Cell Stress Chaperones; 2014 Mar; 19(2):227-39. PubMed ID: 23904097
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human J-protein DnaJB6b Cures a Subset of Saccharomyces cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids.
    Reidy M; Sharma R; Roberts BL; Masison DC
    J Biol Chem; 2016 Feb; 291(8):4035-47. PubMed ID: 26702057
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.
    Muchowski PJ; Schaffar G; Sittler A; Wanker EE; Hayer-Hartl MK; Hartl FU
    Proc Natl Acad Sci U S A; 2000 Jul; 97(14):7841-6. PubMed ID: 10859365
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.
    Månsson C; Arosio P; Hussein R; Kampinga HH; Hashem RM; Boelens WC; Dobson CM; Knowles TP; Linse S; Emanuelsson C
    J Biol Chem; 2014 Nov; 289(45):31066-76. PubMed ID: 25217638
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.
    Månsson C; van Cruchten RTP; Weininger U; Yang X; Cukalevski R; Arosio P; Dobson CM; Knowles T; Akke M; Linse S; Emanuelsson C
    Biochemistry; 2018 Aug; 57(32):4891-4902. PubMed ID: 30024736
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides.
    Gillis J; Schipper-Krom S; Juenemann K; Gruber A; Coolen S; van den Nieuwendijk R; van Veen H; Overkleeft H; Goedhart J; Kampinga HH; Reits EA
    J Biol Chem; 2013 Jun; 288(24):17225-37. PubMed ID: 23612975
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation.
    Österlund N; Lundqvist M; Ilag LL; Gräslund A; Emanuelsson C
    J Biol Chem; 2020 Jun; 295(24):8135-8144. PubMed ID: 32350108
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sis1 potentiates the stress response to protein aggregation and elevated temperature.
    Klaips CL; Gropp MHM; Hipp MS; Hartl FU
    Nat Commun; 2020 Dec; 11(1):6271. PubMed ID: 33293525
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation.
    Rodríguez-González C; Lin S; Arkan S; Hansen C
    Sci Rep; 2020 May; 10(1):8130. PubMed ID: 32424160
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington's disease.
    Bason M; Meister-Broekema M; Alberts N; Dijkers P; Bergink S; Sibon OCM; Kampinga HH
    Neurobiol Dis; 2019 Apr; 124():108-117. PubMed ID: 30408590
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.
    Wolfe KJ; Ren HY; Trepte P; Cyr DM
    PLoS One; 2014; 9(5):e95914. PubMed ID: 24828240
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Class-specific interactions between Sis1 J-domain protein and Hsp70 chaperone potentiate disaggregation of misfolded proteins.
    Wyszkowski H; Janta A; Sztangierska W; Obuchowski I; Chamera T; Kłosowska A; Liberek K
    Proc Natl Acad Sci U S A; 2021 Dec; 118(49):. PubMed ID: 34873058
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer.
    Meng E; Shevde LA; Samant RS
    Oncotarget; 2016 Aug; 7(33):53984-53996. PubMed ID: 27276715
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors.
    Bhadra AK; Rau MJ; Daw JA; Fitzpatrick JAJ; Weihl CC; True HL
    Nat Commun; 2022 Aug; 13(1):4570. PubMed ID: 35931773
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.
    Bengoechea R; Findlay AR; Bhadra AK; Shao H; Stein KC; Pittman SK; Daw JA; Gestwicki JE; True HL; Weihl CC
    J Clin Invest; 2020 Aug; 130(8):4470-4485. PubMed ID: 32427588
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates.
    Yue HW; Hong JY; Zhang SX; Jiang LL; Hu HY
    Sci Rep; 2021 Apr; 11(1):7815. PubMed ID: 33837238
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.
    Behrends C; Langer CA; Boteva R; Böttcher UM; Stemp MJ; Schaffar G; Rao BV; Giese A; Kretzschmar H; Siegers K; Hartl FU
    Mol Cell; 2006 Sep; 23(6):887-97. PubMed ID: 16973440
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells.
    Deshayes N; Arkan S; Hansen C
    Int J Mol Sci; 2019 Sep; 20(18):. PubMed ID: 31514384
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones.
    Abayev-Avraham M; Salzberg Y; Gliksberg D; Oren-Suissa M; Rosenzweig R
    Nat Commun; 2023 Nov; 14(1):7066. PubMed ID: 37923706
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.