BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

319 related articles for article (PubMed ID: 30237309)

  • 1. Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt's lymphoma.
    Hartleben G; Müller C; Krämer A; Schimmel H; Zidek LM; Dornblut C; Winkler R; Eichwald S; Kortman G; Kosan C; Kluiver J; Petersen I; van den Berg A; Wang ZQ; Calkhoven CF
    EMBO J; 2018 Nov; 37(21):. PubMed ID: 30237309
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex.
    Wang Y; Tang S; Wu Y; Wan X; Zhou M; Li H; Zha X
    IUBMB Life; 2020 May; 72(5):965-977. PubMed ID: 31958214
    [TBL] [Abstract][Full Text] [Related]  

  • 3. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.
    Ogórek B; Lam HC; Khabibullin D; Liu HJ; Nijmeh J; Triboulet R; Kwiatkowski DJ; Gregory RI; Henske EP
    Hum Mol Genet; 2018 May; 27(9):1654-1663. PubMed ID: 29509898
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
    Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA
    J Biol Chem; 2013 May; 288(22):15687-98. PubMed ID: 23612979
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.
    Mrozek EM; Bajaj V; Guo Y; Malinowska IA; Zhang J; Kwiatkowski DJ
    PLoS One; 2021; 16(4):e0248380. PubMed ID: 33891611
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The specificity and role of microglia in epileptogenesis in mouse models of tuberous sclerosis complex.
    Zhang B; Zou J; Han L; Beeler B; Friedman JL; Griffin E; Piao YS; Rensing NR; Wong M
    Epilepsia; 2018 Sep; 59(9):1796-1806. PubMed ID: 30079598
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells.
    Sakai Y; Kassai H; Nakayama H; Fukaya M; Maeda T; Nakao K; Hashimoto K; Sakagami H; Kano M; Aiba A
    Sci Rep; 2019 Feb; 9(1):2799. PubMed ID: 30808980
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional analysis of Burkitt's lymphoma mutant c-Myc proteins.
    Smith-Sørensen B; Hijmans EM; Beijersbergen RL; Bernards R
    J Biol Chem; 1996 Mar; 271(10):5513-8. PubMed ID: 8621409
    [TBL] [Abstract][Full Text] [Related]  

  • 9. CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling.
    Liao WT; Chiang YJ; Yang-Yen HF; Hsu LC; Chang ZF; Yen JJY
    J Biol Chem; 2023 Dec; 299(12):105455. PubMed ID: 37949232
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
    Di Nardo A; Lenoël I; Winden KD; Rühmkorf A; Modi ME; Barrett L; Ercan-Herbst E; Venugopal P; Behne R; Lopes CAM; Kleiman RJ; Bettencourt-Dias M; Sahin M
    Cell Rep; 2020 Jun; 31(12):107780. PubMed ID: 32579942
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Architecture of the Tuberous Sclerosis Protein Complex.
    Ramlaul K; Fu W; Li H; de Martin Garrido N; He L; Trivedi M; Cui W; Aylett CHS; Wu G
    J Mol Biol; 2021 Jan; 433(2):166743. PubMed ID: 33307091
    [TBL] [Abstract][Full Text] [Related]  

  • 12. TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury.
    Shen J; Cui ZK; Yao F; Li K; Zhang Y; Chen Z; Zhou Y; Xu S; Zhang Y; Jiang W; Zhang H; Tan K; Liu A; Bai X
    Clin Sci (Lond); 2018 Oct; 132(19):2087-2101. PubMed ID: 30185506
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Emerging molecular networks in Burkitt's lymphoma.
    Mangani D; Roberti A; Rizzolio F; Giordano A
    J Cell Biochem; 2013 Jan; 114(1):35-8. PubMed ID: 22903691
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice.
    Haji N; Riebe I; Aguilar-Valles A; Artinian J; Laplante I; Lacaille JC
    Mol Autism; 2020 May; 11(1):29. PubMed ID: 32375878
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.
    Dong P; Wang X; Liu L; Tang W; Ma L; Zeng W; Sun S; Zhang L; Zhang N; Shen X; Janssen HLA; Dong L; Zhang S; Chen S
    J Hepatol; 2020 Dec; 73(6):1446-1459. PubMed ID: 32610114
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The Characterization of a Subependymal Giant Astrocytoma-Like Cell Line from Murine Astrocyte with mTORC1 Hyperactivation.
    Tang X; Angst G; Haas M; Yang F; Wang C
    Int J Mol Sci; 2021 Apr; 22(8):. PubMed ID: 33923449
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.
    Liu W; Wang Z; Yang J; Wang Y; Li K; Huang B; Yan B; Wang T; Li M; Zou Z; Yang J; Xiao G; Cui ZK; Liu A; Bai X
    Open Biol; 2019 May; 9(5):180262. PubMed ID: 31088250
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism.
    Schwarz JM; Pedrazza L; Stenzel W; Rosa JL; Schuelke M; Straussberg R
    Mol Genet Metab; 2020; 131(1-2):126-134. PubMed ID: 32921582
    [TBL] [Abstract][Full Text] [Related]  

  • 19. mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci.
    Kelsey I; Zbinden M; Byles V; Torrence M; Manning BD
    Sci Rep; 2017 Nov; 7(1):16112. PubMed ID: 29170467
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.
    Johnson CE; Dunlop EA; Seifan S; McCann HD; Hay T; Parfitt GJ; Jones AT; Giles PJ; Shen MH; Sampson JR; Errington RJ; Davies DM; Tee AR
    Oncogene; 2018 Nov; 37(45):5913-5925. PubMed ID: 29980790
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.