These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 30243991)

  • 1. Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice.
    Urano Y; Oda S; Tsuneyama K; Yokoi T
    Chem Biol Interact; 2018 Dec; 296():185-197. PubMed ID: 30243991
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury.
    Wolenski FS; Zhu AZX; Johnson M; Yu S; Moriya Y; Ebihara T; Csizmadia V; Grieves J; Paton M; Liao M; Gemski C; Pan L; Vakilynejad M; Dragan YP; Chowdhury SK; Kirby PJ
    Toxicol Sci; 2017 May; 157(1):50-61. PubMed ID: 28108665
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury.
    Otieno MA; Snoeys J; Lam W; Ghosh A; Player MR; Pocai A; Salter R; Simic D; Skaggs H; Singh B; Lim HK
    Toxicol Sci; 2018 Jun; 163(2):374-384. PubMed ID: 28206647
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
    Longo DM; Woodhead JL; Walker P; Herédi-Szabó K; Mogyorósi K; Wolenski FS; Dragan YP; Mosedale M; Siler SQ; Watkins PB; Howell BA
    Toxicol Sci; 2019 Feb; 167(2):458-467. PubMed ID: 30289550
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury.
    Li X; Zhong K; Guo Z; Zhong D; Chen X
    Drug Metab Dispos; 2015 Nov; 43(11):1751-9. PubMed ID: 26276582
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience.
    Marcinak JF; Munsaka MS; Watkins PB; Ohira T; Smith N
    Drug Saf; 2018 Jun; 41(6):625-640. PubMed ID: 29492878
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice.
    Li C; Ming Y; Hong W; Tang Y; Lei X; Li X; Mao Y
    Toxicol Lett; 2018 Feb; 283():69-76. PubMed ID: 29174983
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice.
    Mosedale M; Cai Y; Eaddy JS; Kirby PJ; Wolenski FS; Dragan Y; Valdar W
    Toxicology; 2021 Sep; 461():152902. PubMed ID: 34418498
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey.
    Bazydlo-Guzenda K; Buda P; Mach M; Pieczykolan J; Kozlowska I; Janiszewski M; Drzazga E; Dominowski J; Ziolkowski H; Wieczorek M; Gad SC
    PLoS One; 2021; 16(9):e0257477. PubMed ID: 34555055
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans.
    Kogame A; Lee R; Pan L; Sudo M; Nonaka M; Moriya Y; Higuchi T; Tagawa Y
    Xenobiotica; 2019 Apr; 49(4):433-445. PubMed ID: 29557709
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Transcriptomic analysis reveals the mechanism of sulfasalazine-induced liver injury in mice.
    Li YC; Shen JD; Lu SF; Zhu LL; Wang BY; Bai M; Xu EP
    Toxicol Lett; 2020 Mar; 321():12-20. PubMed ID: 31830553
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 4-Phenylbutyric acid regulates CCl4-induced acute hepatic dyslipidemia in a mouse model: A mechanism-based PK/PD study.
    Lee HY; Marahatta A; Bhandary B; Kim HR; Chae HJ
    Eur J Pharmacol; 2016 Apr; 777():104-12. PubMed ID: 26948310
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate.
    Yan S; Zhang H; Wang J; Zheng F; Dai J
    Free Radic Biol Med; 2015 Oct; 87():300-11. PubMed ID: 26159507
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice.
    Xie J; Liu J; Chen TM; Lan Q; Zhang QY; Liu B; Dai D; Zhang WD; Hu LP; Zhu RZ
    World J Gastroenterol; 2015 May; 21(18):5473-81. PubMed ID: 25987769
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production.
    Wang H; Zhang H; Zhang Y; Wang D; Cheng X; Yang F; Zhang Q; Xue Z; Li Y; Zhang L; Yang L; Miao G; Li D; Guan Z; Da Y; Yao Z; Gao F; Qiao L; Kong L; Zhang R
    Oncotarget; 2016 Dec; 7(50):82864-82875. PubMed ID: 27756878
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
    Srivastava A; Yano J; Hirozane Y; Kefala G; Gruswitz F; Snell G; Lane W; Ivetac A; Aertgeerts K; Nguyen J; Jennings A; Okada K
    Nature; 2014 Sep; 513(7516):124-7. PubMed ID: 25043059
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.
    Akihara R; Homma T; Lee J; Yamada K; Miyata S; Fujii J
    Biochem Biophys Res Commun; 2016 Sep; 478(2):765-71. PubMed ID: 27501753
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner.
    Kim M; Gu GJ; Koh YS; Lee SH; Na YR; Seok SH; Lim KM
    Biomol Ther (Seoul); 2018 Nov; 26(6):599-607. PubMed ID: 29429148
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of Fasiglifam-Related Liver Toxicity in Dogs.
    Kogame A; Moriya Y; Mori I; Pan L; Morohashi A; Ebihara T; Fukui H; Tagawa Y; Benet LZ
    Drug Metab Dispos; 2019 May; 47(5):525-534. PubMed ID: 30765394
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice.
    Wang JQ; Chen X; Zhang C; Tao L; Zhang ZH; Liu XQ; Xu YB; Wang H; Li J; Xu DX
    Toxicol Appl Pharmacol; 2013 Jan; 266(2):307-16. PubMed ID: 23174480
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.