BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 30247740)

  • 1. Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.
    Giustarini G; Vrisekoop N; Kruijssen L; Wagenaar L; van Staveren S; van Roest M; Bleumink R; Bol-Schoenmakers M; Weaver RJ; Koenderman L; Smit J; Pieters R
    Toxicol Sci; 2019 Feb; 167(2):385-396. PubMed ID: 30247740
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice.
    Giustarini G; Kruijssen L; van Roest M; Bleumink R; Weaver RJ; Bol-Schoenmakers M; Smit J; Pieters R
    J Appl Toxicol; 2018 May; 38(5):753-765. PubMed ID: 29377180
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
    Beggs KM; Maiuri AR; Fullerton AM; Poulsen KL; Breier AB; Ganey PE; Roth RA
    Toxicology; 2015 May; 331():35-46. PubMed ID: 25748550
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure.
    Shaw PJ; Ganey PE; Roth RA
    J Pharmacol Exp Ther; 2009 Jan; 328(1):62-8. PubMed ID: 18820134
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice.
    Shaw PJ; Ganey PE; Roth RA
    J Pharmacol Exp Ther; 2009 Jul; 330(1):72-8. PubMed ID: 19351866
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction.
    Beggs KM; Fullerton AM; Miyakawa K; Ganey PE; Roth RA
    Toxicol Sci; 2014 Jan; 137(1):91-101. PubMed ID: 24097668
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.
    Shaw PJ; Beggs KM; Sparkenbaugh EM; Dugan CM; Ganey PE; Roth RA
    Toxicol Sci; 2009 Oct; 111(2):288-301. PubMed ID: 19638433
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro.
    Giustarini G; Huppelschoten S; Barra M; Oppelt A; Wagenaar L; Weaver RJ; Bol-Schoenmakers M; Smit JJ; van de Water B; Klingmüller U; Pieters RHH
    Toxicol Appl Pharmacol; 2020 Mar; 391():114915. PubMed ID: 32035082
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TNFα enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy.
    Ahn JH; Jegal H; Choi MS; Kim S; Park SM; Ahn J; Han HY; Cho HS; Yoon S; Oh JH
    Toxicol Lett; 2021 May; 342():73-84. PubMed ID: 33609687
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.
    Shaw PJ; Ditewig AC; Waring JF; Liguori MJ; Blomme EA; Ganey PE; Roth RA
    Toxicol Sci; 2009 Jan; 107(1):270-80. PubMed ID: 18930950
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.
    Waring JF; Liguori MJ; Luyendyk JP; Maddox JF; Ganey PE; Stachlewitz RF; North C; Blomme EA; Roth RA
    J Pharmacol Exp Ther; 2006 Mar; 316(3):1080-7. PubMed ID: 16299187
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.
    Shaw PJ; Hopfensperger MJ; Ganey PE; Roth RA
    Toxicol Sci; 2007 Nov; 100(1):259-66. PubMed ID: 17709330
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response.
    Poulsen KL; Olivero-Verbel J; Beggs KM; Ganey PE; Roth RA
    J Pharmacol Exp Ther; 2014 Jul; 350(1):164-70. PubMed ID: 24817034
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability.
    Shaw PJ; Fullerton AM; Scott MA; Ganey PE; Roth RA
    Toxicol Appl Pharmacol; 2009 May; 236(3):293-300. PubMed ID: 19367693
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example.
    Liguori MJ; Ditewig AC; Maddox JF; Luyendyk JP; Lehman-McKeeman LD; Nelson DM; Bhaskaran VM; Waring JF; Ganey PE; Roth RA; Blomme EA
    Int J Mol Sci; 2010 Nov; 11(11):4697-714. PubMed ID: 21151465
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Trovafloxacin potentiation of lipopolysaccharide-induced tumor necrosis factor release from RAW 264.7 cells requires extracellular signal-regulated kinase and c-Jun N-Terminal Kinase.
    Poulsen KL; Albee RP; Ganey PE; Roth RA
    J Pharmacol Exp Ther; 2014 May; 349(2):185-91. PubMed ID: 24525298
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction.
    Hsiao CJ; Younis H; Boelsterli UA
    Chem Biol Interact; 2010 Oct; 188(1):204-13. PubMed ID: 20655887
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Trovafloxacin drives inflammation-associated drug-induced adverse hepatic reaction by changing macrophage polarization.
    Yang H; Park T; Park D; Kang MG
    Toxicol In Vitro; 2022 Aug; 82():105374. PubMed ID: 35537566
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The role of neutrophils in triptolide-induced liver injury.
    Wang XZ; Zhang SY; Xu Y; Zhang LY; Jiang ZZ
    Chin J Nat Med; 2018 Sep; 16(9):653-664. PubMed ID: 30269842
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hepatotoxicants induce cytokine imbalance in response to innate immune system.
    Goto S; Deguchi J; Nishio N; Nomura N; Funabashi H
    J Toxicol Sci; 2015 Jun; 40(3):389-404. PubMed ID: 25972199
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.