BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 30247945)

  • 1. Dacomitinib: an investigational drug for the treatment of glioblastoma.
    Sepúlveda JM; Sánchez-Gómez P; Vaz Salgado MÁ; Gargini R; Balañá C
    Expert Opin Investig Drugs; 2018 Oct; 27(10):823-829. PubMed ID: 30247945
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phase II trial of dacomitinib, a pan-human EGFR tyrosine kinase inhibitor, in recurrent glioblastoma patients with EGFR amplification.
    Sepúlveda-Sánchez JM; Vaz MÁ; Balañá C; Gil-Gil M; Reynés G; Gallego Ó; Martínez-García M; Vicente E; Quindós M; Luque R; Ramos A; Ruano Y; Pérez-Segura P; Benavides M; Sánchez-Gómez P; Hernández-Laín A
    Neuro Oncol; 2017 Oct; 19(11):1522-1531. PubMed ID: 28575464
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era?
    Ou SH; Soo RA
    Drug Des Devel Ther; 2015; 9():5641-53. PubMed ID: 26508839
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dacomitinib, a new therapy for the treatment of non-small cell lung cancer.
    Brzezniak C; Carter CA; Giaccone G
    Expert Opin Pharmacother; 2013 Feb; 14(2):247-53. PubMed ID: 23294134
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab.
    Lv S; Teugels E; Sadones J; De Brakeleer S; Duerinck J; Du Four S; Michotte A; De Grève J; Neyns B
    Int J Oncol; 2012 Sep; 41(3):1029-35. PubMed ID: 22752145
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Preclinical Test of Dacomitinib, an Irreversible EGFR Inhibitor, Confirms Its Effectiveness for Glioblastoma.
    Zahonero C; Aguilera P; Ramírez-Castillejo C; Pajares M; Bolós MV; Cantero D; Perez-Nuñez A; Hernández-Laín A; Sánchez-Gómez P; Sepúlveda JM
    Mol Cancer Ther; 2015 Jul; 14(7):1548-58. PubMed ID: 25939761
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dacomitinib for the treatment of advanced or metastatic non-small-cell lung cancer.
    Mok T; Lee K; Tang M; Leung L
    Future Oncol; 2014 Apr; 10(5):813-22. PubMed ID: 24799062
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors.
    Kris MG; Camidge DR; Giaccone G; Hida T; Li BT; O'Connell J; Taylor I; Zhang H; Arcila ME; Goldberg Z; Jänne PA
    Ann Oncol; 2015 Jul; 26(7):1421-7. PubMed ID: 25899785
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384.
    Zhu Y; Shah K
    Cancer Biol Ther; 2014 Jun; 15(6):815-22. PubMed ID: 24658109
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Current Role of Dacomitinib in Head and Neck Cancer.
    Elicin O; Ozsahin M
    Expert Opin Investig Drugs; 2016 Jun; 25(6):735-42. PubMed ID: 27070370
    [TBL] [Abstract][Full Text] [Related]  

  • 11. First-line therapy with dacomitinib, an orally available pan-HER tyrosine kinase inhibitor, for locally advanced or metastatic penile squamous cell carcinoma: results of an open-label, single-arm, single-centre, phase 2 study.
    Necchi A; Lo Vullo S; Perrone F; Raggi D; Giannatempo P; Calareso G; Nicolai N; Piva L; Biasoni D; Catanzaro M; Torelli T; Stagni S; Togliardi E; Colecchia M; Busico A; Gloghini A; Testi A; Mariani L; Salvioni R
    BJU Int; 2018 Mar; 121(3):348-356. PubMed ID: 28921872
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial.
    Ellis PM; Shepherd FA; Millward M; Perrone F; Seymour L; Liu G; Sun S; Cho BC; Morabito A; Leighl NB; Stockler MR; Lee CW; Wierzbicki R; Cohen V; Blais N; Sangha RS; Favaretto AG; Kang JH; Tsao MS; Wilson CF; Goldberg Z; Ding K; Goss GD; Bradbury PA; ; ;
    Lancet Oncol; 2014 Nov; 15(12):1379-88. PubMed ID: 25439692
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy.
    Tanaka S; Luk S; Kiyokawa J; Onozato ML; Iafrate AJ; Shah K; Martuza RL; Rabkin SD; Batchelor TT; Cahill DP; Chi AS; Wakimoto H
    Sci Rep; 2019 Jan; 9(1):139. PubMed ID: 30644426
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap? A review of the clinical evidence.
    Ou SH
    Crit Rev Oncol Hematol; 2012 Sep; 83(3):407-21. PubMed ID: 22257651
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors.
    Endersby R; Whitehouse J; Hii H; Greenall SA; Johns TG; Gottardo NG
    Neoplasia; 2018 May; 20(5):432-442. PubMed ID: 29574250
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
    Mellinghoff IK; Wang MY; Vivanco I; Haas-Kogan DA; Zhu S; Dia EQ; Lu KV; Yoshimoto K; Huang JH; Chute DJ; Riggs BL; Horvath S; Liau LM; Cavenee WK; Rao PN; Beroukhim R; Peck TC; Lee JC; Sellers WR; Stokoe D; Prados M; Cloughesy TF; Sawyers CL; Mischel PS
    N Engl J Med; 2005 Nov; 353(19):2012-24. PubMed ID: 16282176
    [TBL] [Abstract][Full Text] [Related]  

  • 17. InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma.
    Ma Y; Tang N; Thompson RC; Mobley BC; Clark SW; Sarkaria JN; Wang J
    Clin Cancer Res; 2016 Apr; 22(7):1767-76. PubMed ID: 26561558
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Epidermal growth factor receptor: a re-emerging target in glioblastoma.
    Hegi ME; Rajakannu P; Weller M
    Curr Opin Neurol; 2012 Dec; 25(6):774-9. PubMed ID: 23007009
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Exploring Predictors of Response to Dacomitinib in
    Chi AS; Cahill DP; Reardon DA; Wen PY; Mikkelsen T; Peereboom DM; Wong ET; Gerstner ER; Dietrich J; Plotkin SR; Norden AD; Lee EQ; Nayak L; Tanaka S; Wakimoto H; Lelic N; Koerner MV; Klofas LK; Bertalan MS; Arrillaga-Romany IC; Betensky RA; Curry WT; Borger DR; Balaj L; Kitchen RR; Chakrabortty SK; Valentino MD; Skog J; Breakefield XO; Iafrate AJ; Batchelor TT
    JCO Precis Oncol; 2020; 4():. PubMed ID: 32923886
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.
    Greenall SA; Donoghue JF; Gottardo NG; Johns TG; Adams TE
    Oncogene; 2015 Mar; 34(13):1658-66. PubMed ID: 24747966
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.