BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

417 related articles for article (PubMed ID: 30249616)

  • 1. Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors.
    Hone AJ; Talley TT; Bobango J; Huidobro Melo C; Hararah F; Gajewiak J; Christensen S; Harvey PJ; Craik DJ; McIntosh JM
    J Biol Chem; 2018 Nov; 293(46):17838-17852. PubMed ID: 30249616
    [TBL] [Abstract][Full Text] [Related]  

  • 2. α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors.
    Hone AJ; Scadden M; Gajewiak J; Christensen S; Lindstrom J; McIntosh JM
    Mol Pharmacol; 2012 Nov; 82(5):972-82. PubMed ID: 22914547
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins.
    Cuny H; Kompella SN; Tae HS; Yu R; Adams DJ
    J Biol Chem; 2016 Nov; 291(45):23779-23792. PubMed ID: 27646000
    [TBL] [Abstract][Full Text] [Related]  

  • 4. α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.
    Wu Y; Zhangsun D; Zhu X; Kaas Q; Zhangsun M; Harvey PJ; Craik DJ; McIntosh JM; Luo S
    J Med Chem; 2017 Jul; 60(13):5826-5833. PubMed ID: 28603989
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.
    Luo S; Zhangsun D; Schroeder CI; Zhu X; Hu Y; Wu Y; Weltzin MM; Eberhard S; Kaas Q; Craik DJ; McIntosh JM; Whiteaker P
    FASEB J; 2014 Apr; 28(4):1842-53. PubMed ID: 24398291
    [TBL] [Abstract][Full Text] [Related]  

  • 6. α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors.
    van Hout M; Valdes A; Christensen SB; Tran PT; Watkins M; Gajewiak J; Jensen AA; Olivera BM; McIntosh JM
    Neuropharmacology; 2019 Oct; 157():107691. PubMed ID: 31255696
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.
    Hone AJ; Ruiz M; Scadden M; Christensen S; Gajewiak J; Azam L; McIntosh JM
    J Biol Chem; 2013 Aug; 288(35):25428-25439. PubMed ID: 23846688
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs.
    Hone AJ; Kaas Q; Kearns I; Hararah F; Gajewiak J; Christensen S; Craik DJ; McIntosh JM
    J Med Chem; 2021 Feb; 64(3):1685-1700. PubMed ID: 33523678
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors.
    Xie T; Qin Y; Zhao J; Dong J; Qi P; Zhang P; Zhangsun D; Zhu X; Yu J; Luo S
    Int J Mol Sci; 2023 May; 24(10):. PubMed ID: 37239959
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.
    Grishin AA; Cuny H; Hung A; Clark RJ; Brust A; Akondi K; Alewood PF; Craik DJ; Adams DJ
    J Biol Chem; 2013 Nov; 288(48):34428-42. PubMed ID: 24100032
    [TBL] [Abstract][Full Text] [Related]  

  • 11. α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells.
    Hone AJ; McIntosh JM; Azam L; Lindstrom J; Lucero L; Whiteaker P; Passas J; Blázquez J; Albillos A
    Mol Pharmacol; 2015 Nov; 88(5):881-93. PubMed ID: 26330550
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery, Characterization, and Engineering of LvIC, an α4/4-Conotoxin That Selectively Blocks Rat α6/α3β4 Nicotinic Acetylcholine Receptors.
    Zhu X; Wang S; Kaas Q; Yu J; Wu Y; Harvey PJ; Zhangsun D; Craik DJ; Luo S
    J Med Chem; 2023 Feb; 66(3):2020-2031. PubMed ID: 36682014
    [TBL] [Abstract][Full Text] [Related]  

  • 13. α-Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and α3β2 nicotinic acetylcholine receptor subtypes.
    Ning H; Huang B; Tae HS; Liu Z; Yu S; Li L; Zhang L; Adams DJ; Guo C; Dai Q
    J Neurochem; 2021 Oct; 159(1):90-100. PubMed ID: 34008858
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.
    Grishin AA; Wang CI; Muttenthaler M; Alewood PF; Lewis RJ; Adams DJ
    J Biol Chem; 2010 Jul; 285(29):22254-63. PubMed ID: 20466726
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors.
    McIntosh JM; Azam L; Staheli S; Dowell C; Lindstrom JM; Kuryatov A; Garrett JE; Marks MJ; Whiteaker P
    Mol Pharmacol; 2004 Apr; 65(4):944-52. PubMed ID: 15044624
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Acetylcholine promotes binding of α-conotoxin MII at α3 β2 nicotinic acetylcholine receptors.
    Sambasivarao SV; Roberts J; Bharadwaj VS; Slingsby JG; Rohleder C; Mallory C; Groome JR; McDougal OM; Maupin CM
    Chembiochem; 2014 Feb; 15(3):413-24. PubMed ID: 24420650
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors.
    McIntosh JM; Plazas PV; Watkins M; Gomez-Casati ME; Olivera BM; Elgoyhen AB
    J Biol Chem; 2005 Aug; 280(34):30107-12. PubMed ID: 15983035
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB.
    Wu X; Tae HS; Huang YH; Adams DJ; Craik DJ; Kaas Q
    Biochem Pharmacol; 2018 Sep; 155():288-297. PubMed ID: 30009767
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.
    Luo S; Akondi KB; Zhangsun D; Wu Y; Zhu X; Hu Y; Christensen S; Dowell C; Daly NL; Craik DJ; Wang CI; Lewis RJ; Alewood PF; Michael McIntosh J
    J Biol Chem; 2010 Apr; 285(16):12355-66. PubMed ID: 20145249
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.
    Zhangsun D; Zhu X; Wu Y; Hu Y; Kaas Q; Craik DJ; McIntosh JM; Luo S
    J Biol Chem; 2015 Apr; 290(15):9855-62. PubMed ID: 25713061
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.