BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

289 related articles for article (PubMed ID: 30254335)

  • 21. USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer.
    Lee MY; Kim MJ; Jin JO; Lee PC
    BMB Rep; 2023 Aug; 56(8):451-456. PubMed ID: 37401238
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
    Gavory G; O'Dowd CR; Helm MD; Flasz J; Arkoudis E; Dossang A; Hughes C; Cassidy E; McClelland K; Odrzywol E; Page N; Barker O; Miel H; Harrison T
    Nat Chem Biol; 2018 Feb; 14(2):118-125. PubMed ID: 29200206
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging.
    Ponnappan S; Palmieri M; Sullivan DH; Ponnappan U
    Mech Ageing Dev; 2013; 134(1-2):53-9. PubMed ID: 23291607
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A 2.2 Å resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
    Molland K; Zhou Q; Mesecar AD
    Acta Crystallogr F Struct Biol Commun; 2014 Mar; 70(Pt 3):283-7. PubMed ID: 24598911
    [TBL] [Abstract][Full Text] [Related]  

  • 25. USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.
    Pozhidaeva A; Valles G; Wang F; Wu J; Sterner DE; Nguyen P; Weinstock J; Kumar KGS; Kanyo J; Wright D; Bezsonova I
    Cell Chem Biol; 2017 Dec; 24(12):1501-1512.e5. PubMed ID: 29056420
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
    Chitta K; Paulus A; Akhtar S; Blake MK; Caulfield TR; Novak AJ; Ansell SM; Advani P; Ailawadhi S; Sher T; Linder S; Chanan-Khan A
    Br J Haematol; 2015 May; 169(3):377-90. PubMed ID: 25691154
    [TBL] [Abstract][Full Text] [Related]  

  • 27. IU1 suppresses proliferation of cervical cancer cells through MDM2 degradation.
    Xu L; Wang J; Yuan X; Yang S; Xu X; Li K; He Y; Wei L; Zhang J; Tian Y
    Int J Biol Sci; 2020; 16(15):2951-2963. PubMed ID: 33061808
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques.
    Di Lello P; Pastor R; Murray JM; Blake RA; Cohen F; Crawford TD; Drobnick J; Drummond J; Kategaya L; Kleinheinz T; Maurer T; Rougé L; Zhao X; Wertz I; Ndubaku C; Tsui V
    J Med Chem; 2017 Dec; 60(24):10056-10070. PubMed ID: 29166018
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity.
    Rossio V; Paulo JA; Chick J; Brasher B; Gygi SP; King RW
    Cell Chem Biol; 2021 Apr; 28(4):487-502.e5. PubMed ID: 33417828
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Qing-Fei-Pai-Du decoction and wogonoside exert anti-inflammatory action through down-regulating USP14 to promote the degradation of activating transcription factor 2.
    Xu X; Xia J; Zhao S; Wang Q; Ge G; Xu F; Liu X; Zhang W; Yang Y
    FASEB J; 2021 Sep; 35(9):e21870. PubMed ID: 34436790
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response.
    Perry JW; Ahmed M; Chang KO; Donato NJ; Showalter HD; Wobus CE
    PLoS Pathog; 2012; 8(7):e1002783. PubMed ID: 22792064
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role.
    Kim RQ; van Dijk WJ; Sixma TK
    J Struct Biol; 2016 Jul; 195(1):11-8. PubMed ID: 27183903
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).
    Davies CW; Chaney J; Korbel G; Ringe D; Petsko GA; Ploegh H; Das C
    Bioorg Med Chem Lett; 2012 Jun; 22(12):3900-4. PubMed ID: 22617491
    [TBL] [Abstract][Full Text] [Related]  

  • 34. USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment.
    Vogel RI; Pulver T; Heilmann W; Mooneyham A; Mullany S; Zhao X; Shahi M; Richter J; Klein M; Chen L; Ding R; Konecny G; Kommoss S; Winterhoff B; Ghebre R; Bazzaro M
    Oncotarget; 2016 May; 7(21):30962-76. PubMed ID: 27121063
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.
    Bashore C; Jaishankar P; Skelton NJ; Fuhrmann J; Hearn BR; Liu PS; Renslo AR; Dueber EC
    ACS Chem Biol; 2020 Jun; 15(6):1392-1400. PubMed ID: 32302100
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Substrate-Induced Facilitated Dissociation of the Competitive Inhibitor from the Active Site of O-Acetyl Serine Sulfhydrylase Reveals a Competitive-Allostery Mechanism.
    Singh AK; Ekka MK; Kaushik A; Pandya V; Singh RP; Banerjee S; Mittal M; Singh V; Kumaran S
    Biochemistry; 2017 Sep; 56(37):5011-5025. PubMed ID: 28805060
    [TBL] [Abstract][Full Text] [Related]  

  • 37. USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites.
    Lee BH; Lu Y; Prado MA; Shi Y; Tian G; Sun S; Elsasser S; Gygi SP; King RW; Finley D
    Nature; 2016 Apr; 532(7599):398-401. PubMed ID: 27074503
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Cellular Assays for Dynamic Quantification of Deubiquitinase Activity and Inhibition.
    Moghadasi SA; Moraes SN; Harris RS
    J Mol Biol; 2023 Dec; 435(23):168316. PubMed ID: 37858708
    [TBL] [Abstract][Full Text] [Related]  

  • 39. A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14.
    Lee BH; Finley D; King RW
    Curr Protoc Chem Biol; 2012 Dec; 4(4):311-30. PubMed ID: 23788557
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme.
    Reverdy C; Conrath S; Lopez R; Planquette C; Atmanene C; Collura V; Harpon J; Battaglia V; Vivat V; Sippl W; Colland F
    Chem Biol; 2012 Apr; 19(4):467-77. PubMed ID: 22520753
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 15.