BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

473 related articles for article (PubMed ID: 30257869)

  • 1. Hypusine, a polyamine-derived amino acid critical for eukaryotic translation.
    Park MH; Wolff EC
    J Biol Chem; 2018 Nov; 293(48):18710-18718. PubMed ID: 30257869
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
    Park MH; Kar RK; Banka S; Ziegler A; Chung WK
    Amino Acids; 2022 Apr; 54(4):485-499. PubMed ID: 34273022
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A).
    Park MH
    J Biochem; 2006 Feb; 139(2):161-9. PubMed ID: 16452303
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Functional significance of eIF5A and its hypusine modification in eukaryotes.
    Park MH; Nishimura K; Zanelli CF; Valentini SR
    Amino Acids; 2010 Feb; 38(2):491-500. PubMed ID: 19997760
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
    Wolff EC; Kang KR; Kim YS; Park MH
    Amino Acids; 2007 Aug; 33(2):341-50. PubMed ID: 17476569
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder.
    Ziegler A; Steindl K; Hanner AS; Kar RK; Prouteau C; Boland A; Deleuze JF; Coubes C; Bézieau S; Küry S; Maystadt I; Le Mao M; Lenaers G; Navet B; Faivre L; Tran Mau-Them F; Zanoni P; Chung WK; Rauch A; Bonneau D; Park MH
    Am J Hum Genet; 2022 Aug; 109(8):1549-1558. PubMed ID: 35858628
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
    Ganapathi M; Padgett LR; Yamada K; Devinsky O; Willaert R; Person R; Au PB; Tagoe J; McDonald M; Karlowicz D; Wolf B; Lee J; Shen Y; Okur V; Deng L; LeDuc CA; Wang J; Hanner A; Mirmira RG; Park MH; Mastracci TL; Chung WK
    Am J Hum Genet; 2019 Feb; 104(2):287-298. PubMed ID: 30661771
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.
    Park JH; Dias CA; Lee SB; Valentini SR; Sokabe M; Fraser CS; Park MH
    Protein Eng Des Sel; 2011 Mar; 24(3):301-9. PubMed ID: 21131325
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.
    Coni S; Serrao SM; Yurtsever ZN; Di Magno L; Bordone R; Bertani C; Licursi V; Ianniello Z; Infante P; Moretti M; Petroni M; Guerrieri F; Fatica A; Macone A; De Smaele E; Di Marcotullio L; Giannini G; Maroder M; Agostinelli E; Canettieri G
    Cell Death Dis; 2020 Dec; 11(12):1045. PubMed ID: 33303756
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).
    Lee SB; Park JH; Folk JE; Deck JA; Pegg AE; Sokabe M; Fraser CS; Park MH
    Biochem J; 2011 Jan; 433(1):205-13. PubMed ID: 20942800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
    Nishimura K; Lee SB; Park JH; Park MH
    Amino Acids; 2012 Feb; 42(2-3):703-10. PubMed ID: 21850436
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
    Schultz CR; Geerts D; Mooney M; El-Khawaja R; Koster J; Bachmann AS
    Biochem J; 2018 Jan; 475(2):531-545. PubMed ID: 29295892
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.
    Park MH; Wolff EC; Folk JE
    Biofactors; 1993 May; 4(2):95-104. PubMed ID: 8347280
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer.
    Nakanishi S; Cleveland JL
    Amino Acids; 2016 Oct; 48(10):2353-62. PubMed ID: 27357307
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.
    Park JH; Wolff EC; Folk JE; Park MH
    J Biol Chem; 2003 Aug; 278(35):32683-91. PubMed ID: 12788913
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Assay of deoxyhypusine hydroxylase activity.
    Park JH; Wolff EC; Park MH
    Methods Mol Biol; 2011; 720():207-16. PubMed ID: 21318876
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins.
    Nguyen S; Leija C; Kinch L; Regmi S; Li Q; Grishin NV; Phillips MA
    J Biol Chem; 2015 Aug; 290(32):19987-98. PubMed ID: 26082486
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening.
    Park MH; Mandal A; Mandal S; Wolff EC
    Amino Acids; 2017 Nov; 49(11):1793-1804. PubMed ID: 28819816
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A.
    Kang KR; Kim YS; Wolff EC; Park MH
    J Biol Chem; 2007 Mar; 282(11):8300-8. PubMed ID: 17213197
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
    Kar RK; Hanner AS; Starost MF; Springer D; Mastracci TL; Mirmira RG; Park MH
    J Biol Chem; 2021 Nov; 297(5):101333. PubMed ID: 34688659
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.