BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 30270266)

  • 1. [Development of an In Vitro System for Evaluating Intestinal Drug Disposition Using Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells].
    Iwao T
    Yakugaku Zasshi; 2018; 138(10):1241-1247. PubMed ID: 30270266
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of mitogen-activated protein kinase kinase, DNA methyltransferase, and transforming growth factor-β promotes differentiation of human induced pluripotent stem cells into enterocytes.
    Kodama N; Iwao T; Kabeya T; Horikawa T; Niwa T; Kondo Y; Nakamura K; Matsunaga T
    Drug Metab Pharmacokinet; 2016 Jun; 31(3):193-200. PubMed ID: 27161454
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclic AMP Signaling Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Intestinal Epithelial Cells.
    Kabeya T; Qiu S; Hibino M; Nagasaki M; Kodama N; Iwao T; Matsunaga T
    Drug Metab Dispos; 2018 Oct; 46(10):1411-1419. PubMed ID: 30068521
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Generation of enterocyte-like cells with pharmacokinetic functions from human induced pluripotent stem cells using small-molecule compounds.
    Iwao T; Kodama N; Kondo Y; Kabeya T; Nakamura K; Horikawa T; Niwa T; Kurose K; Matsunaga T
    Drug Metab Dispos; 2015 Apr; 43(4):603-10. PubMed ID: 25650381
    [TBL] [Abstract][Full Text] [Related]  

  • 5. [Utilization of Human iPS Cells for Evaluation of Drug Disposition and Mucosal Damages in the Small Intestine].
    Iwao T
    Yakugaku Zasshi; 2023; 143(3):243-247. PubMed ID: 36858557
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells.
    Ulvestad M; Nordell P; Asplund A; Rehnström M; Jacobsson S; Holmgren G; Davidson L; Brolén G; Edsbagge J; Björquist P; Küppers-Munther B; Andersson TB
    Biochem Pharmacol; 2013 Sep; 86(5):691-702. PubMed ID: 23856292
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells.
    Matsusaki M; Hikimoto D; Nishiguchi A; Kadowaki K; Ohura K; Imai T; Akashi M
    Biochem Biophys Res Commun; 2015 Feb; 457(3):363-9. PubMed ID: 25576862
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells.
    Vaessen SF; van Lipzig MM; Pieters RH; Krul CA; Wortelboer HM; van de Steeg E
    Drug Metab Dispos; 2017 Apr; 45(4):353-360. PubMed ID: 28153842
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction.
    Takayama K; Negoro R; Yamashita T; Kawai K; Ichikawa M; Mori T; Nakatsu N; Harada K; Ito S; Yamada H; Yamaura Y; Hirata K; Ishida S; Mizuguchi H
    Cell Mol Gastroenterol Hepatol; 2019; 8(3):513-526. PubMed ID: 31228606
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.
    Reese MJ; Savina PM; Generaux GT; Tracey H; Humphreys JE; Kanaoka E; Webster LO; Harmon KA; Clarke JD; Polli JW
    Drug Metab Dispos; 2013 Feb; 41(2):353-61. PubMed ID: 23132334
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells.
    Kabeya T; Mima S; Imakura Y; Miyashita T; Ogura I; Yamada T; Yasujima T; Yuasa H; Iwao T; Matsunaga T
    Drug Metab Pharmacokinet; 2020 Aug; 35(4):374-382. PubMed ID: 32651148
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Usefulness of Human Jejunal Spheroid-Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans.
    Michiba K; Maeda K; Shimomura O; Miyazaki Y; Hashimoto S; Oda T; Kusuhara H
    Drug Metab Dispos; 2022 Mar; 50(3):204-213. PubMed ID: 34992074
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells.
    Onozato D; Yamashita M; Nakanishi A; Akagawa T; Kida Y; Ogawa I; Hashita T; Iwao T; Matsunaga T
    Drug Metab Dispos; 2018 Nov; 46(11):1572-1580. PubMed ID: 29615438
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells.
    Kodama N; Iwao T; Katano T; Ohta K; Yuasa H; Matsunaga T
    Drug Metab Dispos; 2016 Oct; 44(10):0. PubMed ID: 27417181
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human small intestinal epithelial cells differentiated from adult intestinal stem cells as a novel system for predicting oral drug absorption in humans.
    Takenaka T; Harada N; Kuze J; Chiba M; Iwao T; Matsunaga T
    Drug Metab Dispos; 2014 Nov; 42(11):1947-54. PubMed ID: 25200868
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine.
    Akazawa T; Yoshida S; Ohnishi S; Kanazu T; Kawai M; Takahashi K
    Drug Metab Dispos; 2018 Nov; 46(11):1497-1506. PubMed ID: 30135242
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism.
    Yamaura Y; Chapron BD; Wang Z; Himmelfarb J; Thummel KE
    Drug Metab Dispos; 2016 Mar; 44(3):329-35. PubMed ID: 26700954
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.
    Miyauchi E; Tachikawa M; Declèves X; Uchida Y; Bouillot JL; Poitou C; Oppert JM; Mouly S; Bergmann JF; Terasaki T; Scherrmann JM; Lloret-Linares C
    Mol Pharm; 2016 Aug; 13(8):2631-40. PubMed ID: 27347605
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Polycyclic aromatic hydrocarbons in food--efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells.
    Hessel S; Lampen A; Seidel A
    Food Chem Toxicol; 2013 Dec; 62():797-804. PubMed ID: 24140465
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase-Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells.
    Kitaguchi T; Mizota T; Ito M; Ohno K; Kobayashi K; Ogawa I; Qiu S; Iwao T; Hanioka N; Tanaka M; Matsunaga T
    Drug Metab Dispos; 2022 Jan; 50(1):17-23. PubMed ID: 34670778
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.