BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1211 related articles for article (PubMed ID: 30279143)

  • 1. Fisetin is a senotherapeutic that extends health and lifespan.
    Yousefzadeh MJ; Zhu Y; McGowan SJ; Angelini L; Fuhrmann-Stroissnigg H; Xu M; Ling YY; Melos KI; Pirtskhalava T; Inman CL; McGuckian C; Wade EA; Kato JI; Grassi D; Wentworth M; Burd CE; Arriaga EA; Ladiges WL; Tchkonia T; Kirkland JL; Robbins PD; Niedernhofer LJ
    EBioMedicine; 2018 Oct; 36():18-28. PubMed ID: 30279143
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.
    Nambiar A; Kellogg D; Justice J; Goros M; Gelfond J; Pascual R; Hashmi S; Masternak M; Prata L; LeBrasseur N; Limper A; Kritchevsky S; Musi N; Tchkonia T; Kirkland J
    EBioMedicine; 2023 Apr; 90():104481. PubMed ID: 36857968
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies.
    Suvakov S; Ghamrawi R; Cubro H; Tu H; White WM; Tobah YSB; Milic NM; Grande JP; Cunningham JM; Chebib FT; Prata LGPL; Zhu Y; Tchkonia T; Kirkland JL; Nath KA; Milosavljevic A; Garovic VD
    EBioMedicine; 2021 Aug; 70():103536. PubMed ID: 34391091
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
    Hickson LJ; Langhi Prata LGP; Bobart SA; Evans TK; Giorgadze N; Hashmi SK; Herrmann SM; Jensen MD; Jia Q; Jordan KL; Kellogg TA; Khosla S; Koerber DM; Lagnado AB; Lawson DK; LeBrasseur NK; Lerman LO; McDonald KM; McKenzie TJ; Passos JF; Pignolo RJ; Pirtskhalava T; Saadiq IM; Schaefer KK; Textor SC; Victorelli SG; Volkman TL; Xue A; Wentworth MA; Wissler Gerdes EO; Zhu Y; Tchkonia T; Kirkland JL
    EBioMedicine; 2019 Sep; 47():446-456. PubMed ID: 31542391
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
    Zhu Y; Tchkonia T; Pirtskhalava T; Gower AC; Ding H; Giorgadze N; Palmer AK; Ikeno Y; Hubbard GB; Lenburg M; O'Hara SP; LaRusso NF; Miller JD; Roos CM; Verzosa GC; LeBrasseur NK; Wren JD; Farr JN; Khosla S; Stout MB; McGowan SJ; Fuhrmann-Stroissnigg H; Gurkar AU; Zhao J; Colangelo D; Dorronsoro A; Ling YY; Barghouthy AS; Navarro DC; Sano T; Robbins PD; Niedernhofer LJ; Kirkland JL
    Aging Cell; 2015 Aug; 14(4):644-58. PubMed ID: 25754370
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells.
    Murakami T; Inagaki N; Kondoh H
    Front Endocrinol (Lausanne); 2022; 13():869414. PubMed ID: 35432205
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.
    Nogueira-Recalde U; Lorenzo-Gómez I; Blanco FJ; Loza MI; Grassi D; Shirinsky V; Shirinsky I; Lotz M; Robbins PD; Domínguez E; Caramés B
    EBioMedicine; 2019 Jul; 45():588-605. PubMed ID: 31285188
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Prospective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids.
    Wang Y; He Y; Rayman MP; Zhang J
    J Agric Food Chem; 2021 Oct; 69(42):12418-12423. PubMed ID: 34662116
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
    Zhu Y; Tchkonia T; Fuhrmann-Stroissnigg H; Dai HM; Ling YY; Stout MB; Pirtskhalava T; Giorgadze N; Johnson KO; Giles CB; Wren JD; Niedernhofer LJ; Robbins PD; Kirkland JL
    Aging Cell; 2016 Jun; 15(3):428-35. PubMed ID: 26711051
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of HSP90 inhibitors as a novel class of senolytics.
    Fuhrmann-Stroissnigg H; Ling YY; Zhao J; McGowan SJ; Zhu Y; Brooks RW; Grassi D; Gregg SQ; Stripay JL; Dorronsoro A; Corbo L; Tang P; Bukata C; Ring N; Giacca M; Li X; Tchkonia T; Kirkland JL; Niedernhofer LJ; Robbins PD
    Nat Commun; 2017 Sep; 8(1):422. PubMed ID: 28871086
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
    Zhu Y; Prata LGPL; Gerdes EOW; Netto JME; Pirtskhalava T; Giorgadze N; Tripathi U; Inman CL; Johnson KO; Xue A; Palmer AK; Chen T; Schaefer K; Justice JN; Nambiar AM; Musi N; Kritchevsky SB; Chen J; Khosla S; Jurk D; Schafer MJ; Tchkonia T; Kirkland JL
    EBioMedicine; 2022 Mar; 77():103912. PubMed ID: 35292270
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.
    Xu Q; Fu Q; Li Z; Liu H; Wang Y; Lin X; He R; Zhang X; Ju Z; Campisi J; Kirkland JL; Sun Y
    Nat Metab; 2021 Dec; 3(12):1706-1726. PubMed ID: 34873338
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Senolytics improve physical function and increase lifespan in old age.
    Xu M; Pirtskhalava T; Farr JN; Weigand BM; Palmer AK; Weivoda MM; Inman CL; Ogrodnik MB; Hachfeld CM; Fraser DG; Onken JL; Johnson KO; Verzosa GC; Langhi LGP; Weigl M; Giorgadze N; LeBrasseur NK; Miller JD; Jurk D; Singh RJ; Allison DB; Ejima K; Hubbard GB; Ikeno Y; Cubro H; Garovic VD; Hou X; Weroha SJ; Robbins PD; Niedernhofer LJ; Khosla S; Tchkonia T; Kirkland JL
    Nat Med; 2018 Aug; 24(8):1246-1256. PubMed ID: 29988130
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Emerging senolytic agents derived from natural products.
    Li W; Qin L; Feng R; Hu G; Sun H; He Y; Zhang R
    Mech Ageing Dev; 2019 Jul; 181():1-6. PubMed ID: 31077707
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
    Baker DJ; Wijshake T; Tchkonia T; LeBrasseur NK; Childs BG; van de Sluis B; Kirkland JL; van Deursen JM
    Nature; 2011 Nov; 479(7372):232-6. PubMed ID: 22048312
    [TBL] [Abstract][Full Text] [Related]  

  • 16. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe
    Lewinska A; Adamczyk-Grochala J; Bloniarz D; Olszowka J; Kulpa-Greszta M; Litwinienko G; Tomaszewska A; Wnuk M; Pazik R
    Redox Biol; 2020 Jan; 28():101337. PubMed ID: 31622846
    [TBL] [Abstract][Full Text] [Related]  

  • 17. New agents that target senescent cells: the flavone, fisetin, and the BCL-X
    Zhu Y; Doornebal EJ; Pirtskhalava T; Giorgadze N; Wentworth M; Fuhrmann-Stroissnigg H; Niedernhofer LJ; Robbins PD; Tchkonia T; Kirkland JL
    Aging (Albany NY); 2017 Mar; 9(3):955-963. PubMed ID: 28273655
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment.
    Fang Y; Medina D; Stockwell R; McFadden S; Quinn K; Peck MR; Bartke A; Hascup KN; Hascup ER
    Geroscience; 2023 Oct; 45(5):2835-2850. PubMed ID: 37296266
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Targeting senescent cells alleviates obesity-induced metabolic dysfunction.
    Palmer AK; Xu M; Zhu Y; Pirtskhalava T; Weivoda MM; Hachfeld CM; Prata LG; van Dijk TH; Verkade E; Casaclang-Verzosa G; Johnson KO; Cubro H; Doornebal EJ; Ogrodnik M; Jurk D; Jensen MD; Chini EN; Miller JD; Matveyenko A; Stout MB; Schafer MJ; White TA; Hickson LJ; Demaria M; Garovic V; Grande J; Arriaga EA; Kuipers F; von Zglinicki T; LeBrasseur NK; Campisi J; Tchkonia T; Kirkland JL
    Aging Cell; 2019 Jun; 18(3):e12950. PubMed ID: 30907060
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.
    Mahoney SA; Venkatasubramanian R; Darrah MA; Ludwig KR; VanDongen NS; Greenberg NT; Longtine AG; Hutton DA; Brunt VE; Campisi J; Melov S; Seals DR; Rossman MJ; Clayton ZS
    Aging Cell; 2024 Mar; 23(3):e14060. PubMed ID: 38062873
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 61.