142 related articles for article (PubMed ID: 30287839)
1. Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.
Santiago ADS; Couñago RM; Ramos PZ; Godoi PHC; Massirer KB; Gileadi O; Elkins JM
Sci Rep; 2018 Oct; 8(1):14800. PubMed ID: 30287839
[TBL] [Abstract][Full Text] [Related]
2. Binding and structural analyses of potent inhibitors of the human Ca
Profeta GS; Dos Reis CV; Santiago ADS; Godoi PHC; Fala AM; Wells CI; Sartori R; Salmazo APT; Ramos PZ; Massirer KB; Elkins JM; Drewry DH; Gileadi O; Couñago RM
Sci Rep; 2019 Nov; 9(1):16452. PubMed ID: 31712618
[TBL] [Abstract][Full Text] [Related]
3. 14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices.
Petrvalska O; Honzejkova K; Koupilova N; Herman P; Obsilova V; Obsil T
Protein Sci; 2023 Nov; 32(11):e4805. PubMed ID: 37817008
[TBL] [Abstract][Full Text] [Related]
4. 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.
Asquith CRM; Godoi PH; Couñago RM; Laitinen T; Scott JW; Langendorf CG; Oakhill JS; Drewry DH; Zuercher WJ; Koutentis PA; Willson TM; Kalogirou AS
Molecules; 2018 May; 23(5):. PubMed ID: 29783765
[TBL] [Abstract][Full Text] [Related]
5. Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2.
Gerner L; Munack S; Temmerman K; Lawrence-Dörner AM; Besir H; Wilmanns M; Jensen JK; Thiede B; Mills IG; Morth JP
Biochem Biophys Res Commun; 2016 Jul; 476(2):102-7. PubMed ID: 27178209
[TBL] [Abstract][Full Text] [Related]
6. In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.
O'Byrne SN; Scott JW; Pilotte JR; Santiago ADS; Langendorf CG; Oakhill JS; Eduful BJ; Couñago RM; Wells CI; Zuercher WJ; Willson TM; Drewry DH
Molecules; 2020 Jan; 25(2):. PubMed ID: 31941153
[TBL] [Abstract][Full Text] [Related]
7. CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert.
Kylarova S; Psenakova K; Herman P; Obsilova V; Obsil T
Biochim Biophys Acta Gen Subj; 2018 Oct; 1862(10):2304-2313. PubMed ID: 30053538
[TBL] [Abstract][Full Text] [Related]
8. Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
Eduful BJ; O'Byrne SN; Temme L; Asquith CRM; Liang Y; Picado A; Pilotte JR; Hossain MA; Wells CI; Zuercher WJ; Catta-Preta CMC; Zonzini Ramos P; Santiago AS; Couñago RM; Langendorf CG; Nay K; Oakhill JS; Pulliam TL; Lin C; Awad D; Willson TM; Frigo DE; Scott JW; Drewry DH
J Med Chem; 2021 Aug; 64(15):10849-10877. PubMed ID: 34264658
[TBL] [Abstract][Full Text] [Related]
9. Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.
Kukimoto-Niino M; Yoshikawa S; Takagi T; Ohsawa N; Tomabechi Y; Terada T; Shirouzu M; Suzuki A; Lee S; Yamauchi T; Okada-Iwabu M; Iwabu M; Kadowaki T; Minokoshi Y; Yokoyama S
J Biol Chem; 2011 Jun; 286(25):22570-9. PubMed ID: 21504895
[TBL] [Abstract][Full Text] [Related]
10. Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs) Effects on AMP-Activated Protein Kinase (AMPK) Regulation of Chicken Sperm Functions.
Nguyen TM; Combarnous Y; Praud C; Duittoz A; Blesbois E
PLoS One; 2016; 11(1):e0147559. PubMed ID: 26808520
[TBL] [Abstract][Full Text] [Related]
11. An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Price DJ; Drewry DH; Schaller LT; Thompson BD; Reid PR; Maloney PR; Liang X; Banker P; Buckholz RG; Selley PK; McDonald OB; Smith JL; Shearer TW; Cox RF; Williams SP; Reid RA; Tacconi S; Faggioni F; Piubelli C; Sartori I; Tessari M; Wang TY
Bioorg Med Chem Lett; 2018 Jun; 28(10):1958-1963. PubMed ID: 29653895
[TBL] [Abstract][Full Text] [Related]
12. Generation of autonomous activity of Ca(2+)/calmodulin-dependent protein kinase kinase β by autophosphorylation.
Tokumitsu H; Hatano N; Fujimoto T; Yurimoto S; Kobayashi R
Biochemistry; 2011 Sep; 50(38):8193-201. PubMed ID: 21859090
[TBL] [Abstract][Full Text] [Related]
13. Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.
Nanba K; Chen A; Nishimoto K; Rainey WE
Endocrinology; 2015 May; 156(5):1750-6. PubMed ID: 25679868
[TBL] [Abstract][Full Text] [Related]
14. 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).
Psenakova K; Petrvalska O; Kylarova S; Lentini Santo D; Kalabova D; Herman P; Obsilova V; Obsil T
Biochim Biophys Acta Gen Subj; 2018 Jul; 1862(7):1612-1625. PubMed ID: 29649512
[TBL] [Abstract][Full Text] [Related]
15. Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
Takaya D; Niwa H; Mikuni J; Nakamura K; Handa N; Tanaka A; Yokoyama S; Honma T
J Mol Graph Model; 2020 Sep; 99():107599. PubMed ID: 32348940
[TBL] [Abstract][Full Text] [Related]
16. Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.
Charnley AK; Convery MA; Lakdawala Shah A; Jones E; Hardwicke P; Bridges A; Ouellette M; Totoritis R; Schwartz B; King BW; Wisnoski DD; Kang J; Eidam PM; Votta BJ; Gough PJ; Marquis RW; Bertin J; Casillas L
Bioorg Med Chem; 2015 Nov; 23(21):7000-6. PubMed ID: 26455654
[TBL] [Abstract][Full Text] [Related]
17. Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2).
Chen Y; Whitefield B; Nevius E; Hill M; DelRosario J; Sinitsyna N; Shanmugasundaram V; Mukherjee D; Shi L; Mayne CG; Rousseau AM; Bernard SM; Buenviaje J; Khambatta G; El Samin M; Wallace M; Nie Z; Sivakumar P; Hamann LG; McDonnell DP; D'Agostino LA
J Med Chem; 2023 Dec; 66(23):15750-15760. PubMed ID: 38009718
[TBL] [Abstract][Full Text] [Related]
18. Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitors: a novel approach in small molecule discovery.
Devasahayam Arokia Balaya R; Chandrasekaran J; Kanekar S; Kumar Modi P; Dagamajalu S; Gopinathan K; Raju R; Prasad TSK
J Biomol Struct Dyn; 2023; 41(24):15196-15206. PubMed ID: 37029757
[TBL] [Abstract][Full Text] [Related]
19. A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome.
Dong F; Patnaik S; Duan ZH; Kiedrowski M; Penn MS; Mayorga ME
Stem Cells Transl Med; 2017 Sep; 6(9):1759-1766. PubMed ID: 28688176
[TBL] [Abstract][Full Text] [Related]
20. Doing more than just the structure-structural genomics in kinase drug discovery.
Marsden BD; Knapp S
Curr Opin Chem Biol; 2008 Feb; 12(1):40-5. PubMed ID: 18267130
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
