227 related articles for article (PubMed ID: 30289529)
1. Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.
Imai S; Cai T; Yoshida C; Tomita T; Futai E
J Biochem; 2019 Jan; 165(1):37-46. PubMed ID: 30289529
[TBL] [Abstract][Full Text] [Related]
2. Specific Mutations in Aph1 Cause γ-Secretase Activation.
Watanabe H; Yoshida C; Hidaka M; Ogawa T; Tomita T; Futai E
Int J Mol Sci; 2022 Jan; 23(1):. PubMed ID: 35008932
[TBL] [Abstract][Full Text] [Related]
3. Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.
Futai E; Yagishita S; Ishiura S
J Biol Chem; 2009 May; 284(19):13013-22. PubMed ID: 19254953
[TBL] [Abstract][Full Text] [Related]
4. Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.
Futai E; Osawa S; Cai T; Fujisawa T; Ishiura S; Tomita T
J Biol Chem; 2016 Jan; 291(1):435-46. PubMed ID: 26559975
[TBL] [Abstract][Full Text] [Related]
5. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
[TBL] [Abstract][Full Text] [Related]
6. Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.
Cai T; Yonaga M; Tomita T
J Neurosci; 2017 Dec; 37(50):12272-12280. PubMed ID: 29118109
[TBL] [Abstract][Full Text] [Related]
7. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
Fukumori A; Fluhrer R; Steiner H; Haass C
J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
[TBL] [Abstract][Full Text] [Related]
8. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
Cacquevel M; Aeschbach L; Houacine J; Fraering PC
PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
[TBL] [Abstract][Full Text] [Related]
9. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
10. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
Kim M; Bezprozvanny I
Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
[TBL] [Abstract][Full Text] [Related]
11. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.
Fernandez MA; Klutkowski JA; Freret T; Wolfe MS
J Biol Chem; 2014 Nov; 289(45):31043-52. PubMed ID: 25239621
[TBL] [Abstract][Full Text] [Related]
12. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
Liu L; Lauro BM; Wolfe MS; Selkoe DJ
J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
[TBL] [Abstract][Full Text] [Related]
13. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
[TBL] [Abstract][Full Text] [Related]
14. Advanced Yeast Models of Familial Alzheimer Disease Expressing FAD-Linked Presenilin to Screen Mutations and γ-Secretase Modulators.
Futai E
Methods Mol Biol; 2019; 2049():403-417. PubMed ID: 31602624
[TBL] [Abstract][Full Text] [Related]
15. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Page RM; Baumann K; Tomioka M; Pérez-Revuelta BI; Fukumori A; Jacobsen H; Flohr A; Luebbers T; Ozmen L; Steiner H; Haass C
J Biol Chem; 2008 Jan; 283(2):677-83. PubMed ID: 17962197
[TBL] [Abstract][Full Text] [Related]
16. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
[TBL] [Abstract][Full Text] [Related]
17. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
Gong P; Vetrivel KS; Nguyen PD; Meckler X; Cheng H; Kounnas MZ; Wagner SL; Parent AT; Thinakaran G
J Biol Chem; 2010 Dec; 285(49):38042-52. PubMed ID: 20921220
[TBL] [Abstract][Full Text] [Related]
18. Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein.
Do HN; Devkota S; Bhattarai A; Wolfe MS; Miao Y
Commun Biol; 2023 Feb; 6(1):174. PubMed ID: 36788318
[TBL] [Abstract][Full Text] [Related]
19. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M; Sahara N; Mizoroki T; Funamoto S; Morishima-Kawashima M; Kudo T; Takeda M; Ihara Y; Ichinose H; Takashima A
J Biol Chem; 2008 Jun; 283(24):16488-96. PubMed ID: 18430735
[TBL] [Abstract][Full Text] [Related]
20. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]