These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

180 related articles for article (PubMed ID: 30290244)

  • 1. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes.
    Guimaraes PPG; Tan M; Tammela T; Wu K; Chung A; Oberli M; Wang K; Spektor R; Riley RS; Viana CTR; Jacks T; Langer R; Mitchell MJ
    J Control Release; 2018 Nov; 290():75-87. PubMed ID: 30290244
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells.
    Tang Y; Jiang M; Chen A; Qu W; Han X; Zuo J; Xu G; Song Y; Chen C; Ke X
    Mol Med Rep; 2021 Aug; 24(2):. PubMed ID: 34080032
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Delivery of the Porcupine Inhibitor WNT974 in Mice.
    Zhang LS; Lum L
    Methods Mol Biol; 2016; 1481():111-7. PubMed ID: 27590157
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
    Liu J; Pan S; Hsieh MH; Ng N; Sun F; Wang T; Kasibhatla S; Schuller AG; Li AG; Cheng D; Li J; Tompkins C; Pferdekamper A; Steffy A; Cheng J; Kowal C; Phung V; Guo G; Wang Y; Graham MP; Flynn S; Brenner JC; Li C; Villarroel MC; Schultz PG; Wu X; McNamara P; Sellers WR; Petruzzelli L; Boral AL; Seidel HM; McLaughlin ME; Che J; Carey TE; Vanasse G; Harris JL
    Proc Natl Acad Sci U S A; 2013 Dec; 110(50):20224-9. PubMed ID: 24277854
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma.
    Li J; Wu G; Xu Y; Li J; Ruan N; Chen Y; Zhang Q; Xia Q
    Biomed Res Int; 2020; 2020():2527643. PubMed ID: 32104684
    [TBL] [Abstract][Full Text] [Related]  

  • 6. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway.
    Yang JM; Huang HM; Cheng JJ; Huang CL; Lee YC; Chiou CT; Huang HT; Huang NK; Yang YC
    Toxicology; 2018 Dec; 410():65-72. PubMed ID: 30205152
    [TBL] [Abstract][Full Text] [Related]  

  • 7. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974.
    Jang J; Jung Y; Kim Y; Jho EH; Yoon Y
    Sci Rep; 2017 Jan; 7():41612. PubMed ID: 28128299
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug.
    Bagheri M; Tabatabae Far MA; Mirzaei H; Ghasemi F
    Fundam Clin Pharmacol; 2020 Feb; 34(1):51-64. PubMed ID: 31233627
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.
    Shah K; Panchal S; Patel B
    Pharmacol Res; 2021 May; 167():105532. PubMed ID: 33677106
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines.
    Schmidtova S; Kalavska K; Liskova V; Plava J; Miklikova S; Kucerova L; Matuskova M; Rojikova L; Cierna Z; Rogozea A; Konig H; Albany C; Mego M; Chovanec M
    Int J Mol Sci; 2021 Apr; 22(8):. PubMed ID: 33923996
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells.
    Kahlert UD; Suwala AK; Koch K; Natsumeda M; Orr BA; Hayashi M; Maciaczyk J; Eberhart CG
    J Neuropathol Exp Neurol; 2015 Sep; 74(9):889-900. PubMed ID: 26222502
    [TBL] [Abstract][Full Text] [Related]  

  • 12. WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma.
    Zimmerli D; Cecconi V; Valenta T; Hausmann G; Cantù C; Restivo G; Hafner J; Basler K; van den Broek M
    Oncogene; 2018 Jul; 37(27):3753-3762. PubMed ID: 29662191
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.
    Li A; Xu Y; Fan S; Meng J; Shen X; Xiao Q; Li Y; Zhang L; Zhang X; Wu G; Liang C; Wu D
    JCI Insight; 2018 Mar; 3(5):. PubMed ID: 29515026
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor.
    Tzeng HE; Yang L; Chen K; Wang Y; Liu YR; Pan SL; Gaur S; Hu S; Yen Y
    Oncotarget; 2015 May; 6(13):11061-73. PubMed ID: 25857298
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.
    Picco G; Petti C; Centonze A; Torchiaro E; Crisafulli G; Novara L; Acquaviva A; Bardelli A; Medico E
    EMBO Mol Med; 2017 Mar; 9(3):293-303. PubMed ID: 28100566
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
    Mallinger A; Crumpler S; Pichowicz M; Waalboer D; Stubbs M; Adeniji-Popoola O; Wood B; Smith E; Thai C; Henley AT; Georgi K; Court W; Hobbs S; Box G; Ortiz-Ruiz MJ; Valenti M; De Haven Brandon A; TePoele R; Leuthner B; Workman P; Aherne W; Poeschke O; Dale T; Wienke D; Esdar C; Rohdich F; Raynaud F; Clarke PA; Eccles SA; Stieber F; Schiemann K; Blagg J
    J Med Chem; 2015 Feb; 58(4):1717-35. PubMed ID: 25680029
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
    Liu Y; Qi X; Donnelly L; Elghobashi-Meinhardt N; Long T; Zhou RW; Sun Y; Wang B; Li X
    Nature; 2022 Jul; 607(7920):816-822. PubMed ID: 35831507
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice.
    Funck-Brentano T; Nilsson KH; Brommage R; Henning P; Lerner UH; Koskela A; Tuukkanen J; Cohen-Solal M; Movérare-Skrtic S; Ohlsson C
    J Endocrinol; 2018 Jul; 238(1):13-23. PubMed ID: 29720540
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.
    Dong Y; Li K; Xu Z; Ma H; Zheng J; Hu Z; He S; Wu Y; Sun Z; Luo L; Li J; Zhang H; Zhang X
    Bioorg Med Chem; 2015 Nov; 23(21):6855-68. PubMed ID: 26455655
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling.
    Kong LM; Feng T; Wang YY; Li XY; Ye ZN; An T; Qing C; Luo XD; Li Y
    Oncotarget; 2016 Mar; 7(9):10203-14. PubMed ID: 26862734
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.